ES2834498T3 - Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo - Google Patents
Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo Download PDFInfo
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- ES2834498T3 ES2834498T3 ES14824715T ES14824715T ES2834498T3 ES 2834498 T3 ES2834498 T3 ES 2834498T3 ES 14824715 T ES14824715 T ES 14824715T ES 14824715 T ES14824715 T ES 14824715T ES 2834498 T3 ES2834498 T3 ES 2834498T3
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- B29C43/22—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length
- B29C43/28—Compression moulding, i.e. applying external pressure to flow the moulding material; Apparatus therefor of articles of indefinite length incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2067/00—Use of polyesters or derivatives thereof, as moulding material
- B29K2067/04—Polyesters derived from hydroxycarboxylic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2009/00—Layered products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T428/1393—Multilayer [continuous layer]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24273—Structurally defined web or sheet [e.g., overall dimension, etc.] including aperture
- Y10T428/24322—Composite web or sheet
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
- Y10T442/102—Woven scrim
- Y10T442/183—Synthetic polymeric fiber
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/10—Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
- Y10T442/184—Nonwoven scrim
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920970P | 2013-12-26 | 2013-12-26 | |
| PCT/US2014/071073 WO2015100120A1 (fr) | 2013-12-26 | 2014-12-18 | Implants médicaux comprenant des stratifiés de poly-4-hydroxybutyrate et des copolymères de ce dernier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2834498T3 true ES2834498T3 (es) | 2021-06-17 |
Family
ID=52293277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14824715T Active ES2834498T3 (es) | 2013-12-26 | 2014-12-18 | Implantes médicos que incluyen laminados de poli-4-hidroxibutirato y copolímeros del mismo |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11154642B2 (fr) |
| EP (1) | EP3086820B1 (fr) |
| CA (1) | CA2933746C (fr) |
| ES (1) | ES2834498T3 (fr) |
| WO (1) | WO2015100120A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ITUB20153348A1 (it) * | 2015-09-02 | 2017-03-02 | Tensive S R L | Dispositivo medico biodegradabile per ricostruzione e/o aumento del seno |
| CN107551322A (zh) * | 2017-10-31 | 2018-01-09 | 无锡中科光远生物材料有限公司 | 一种用于膀胱修复的复合支架材料 |
| EP3720514B1 (fr) | 2017-12-04 | 2022-04-13 | Tepha, Inc. | Implants médicaux thermoformés en poly-4-hydroxybutyrate par membrane sous vide |
| CN108653824A (zh) * | 2018-06-08 | 2018-10-16 | 段降龙 | 一种新型生物补片及其制备方法 |
| CN111378056B (zh) * | 2018-12-31 | 2022-12-02 | 江苏苏博特新材料股份有限公司 | 一种壳寡糖中间体及其制备方法和其用于制备膦酸盐减水剂的应用 |
| ES2791771B2 (es) * | 2019-05-03 | 2021-05-11 | Nanomateriales Y Polimeros S L | Membrana hidrófila de nanofibras no tejidas para promover la regeneración ósea |
| CN111097069A (zh) * | 2019-07-04 | 2020-05-05 | 南开大学 | 一种利用拓扑结构调控免疫微环境并引导再生的仿生可降解人工神经导管及其制备方法 |
| US11752239B2 (en) * | 2020-03-12 | 2023-09-12 | Taiwan Fiber Optics, Inc. | Combination bioactive silicate medicine carrier and shunt |
| US12064330B2 (en) | 2020-04-28 | 2024-08-20 | Covidien Lp | Implantable prothesis for minimally invasive hernia repair |
| FR3113371A1 (fr) * | 2020-08-12 | 2022-02-18 | Ph Tech | Dispositif médical comprenant un assemblage d’éléments de matrices biologiques acellulaires et au moins un polymère |
| US11643574B2 (en) * | 2021-05-28 | 2023-05-09 | Cohesys Inc. | Adhesive devices and uses thereof |
| WO2022251710A2 (fr) | 2021-05-28 | 2022-12-01 | Sight Sciences, Inc. | Dispositifs intraoculaires, systèmes et méthodes |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4041206A (en) * | 1974-03-03 | 1977-08-09 | Toray Industries, Inc. | Laminated polyester film |
| US5876550A (en) * | 1988-10-05 | 1999-03-02 | Helisys, Inc. | Laminated object manufacturing apparatus and method |
| US5811272A (en) | 1996-07-26 | 1998-09-22 | Massachusetts Institute Of Technology | Method for controlling molecular weight of polyhydroxyalkanoates |
| US6610764B1 (en) | 1997-05-12 | 2003-08-26 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US6867248B1 (en) | 1997-05-12 | 2005-03-15 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| WO1998051812A2 (fr) | 1997-05-12 | 1998-11-19 | Metabolix, Inc. | POLYHYDROXYALCANOATES DESTINES A DES APPLICATIONS $i(IN VIVO) |
| US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
| US6309659B1 (en) | 1997-09-02 | 2001-10-30 | Gensci Orthobiologics, Inc. | Reverse phase connective tissue repair composition |
| EP1015565B1 (fr) | 1997-09-19 | 2006-04-12 | Metabolix, Inc. | Systemes biologiques utilises pour produire des polymeres de polyhydroxyalcanoate contenant des acides 4-hydroxy |
| ES2281147T3 (es) | 1997-12-22 | 2007-09-16 | Metabolix, Inc. | Composiciones de polihidroxialcanoato con tasas controladas de degradacion. |
| ATE483023T1 (de) | 1998-05-22 | 2010-10-15 | Metabolix Inc | Polyhydroxyalkanoatbiopolymere |
| JP5031144B2 (ja) | 1999-03-25 | 2012-09-19 | メタボリックス，インコーポレイテッド | ポリヒドロキシアルカノエートポリマーの医療デバイスおよび医療適用 |
| US7025980B1 (en) | 1999-09-14 | 2006-04-11 | Tepha, Inc. | Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation |
| US8039237B2 (en) | 2002-05-10 | 2011-10-18 | Metabolix, Inc. | Bioabsorbable polymer containing 2-hydroxyacid monomers |
| ATE504262T1 (de) | 2002-07-17 | 2011-04-15 | Proxy Biomedical Ltd | Membrane für medizinische implantation |
| ES2527857T3 (es) | 2003-05-08 | 2015-01-30 | Tepha, Inc. | Tejidos y fibras médicas de polihidroxialcanoato |
| US20050060020A1 (en) * | 2003-09-17 | 2005-03-17 | Scimed Life Systems, Inc. | Covered stent with biologically active material |
| PT1778305E (pt) | 2004-08-03 | 2010-07-27 | Tepha Inc | Suturas de poli-hidroxialcanoato que no se enrolam |
| ES2624589T3 (es) | 2006-02-07 | 2017-07-17 | Tepha, Inc. | Métodos y dispositivos para la reparación del manguito de los rotadores |
| US7618448B2 (en) | 2006-02-07 | 2009-11-17 | Tepha, Inc. | Polymeric, degradable drug-eluting stents and coatings |
| US7943683B2 (en) | 2006-12-01 | 2011-05-17 | Tepha, Inc. | Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers |
| US7678444B2 (en) * | 2007-12-17 | 2010-03-16 | International Paper Company | Thermoformed article made from renewable polymer and heat-resistant polymer |
| US8287909B2 (en) | 2007-12-19 | 2012-10-16 | Tepha, Inc. | Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof |
| US20090274920A1 (en) | 2008-05-05 | 2009-11-05 | International Paper Company | Thermoformed Article Made From Bio-Based Biodegradable Polymer Composition |
| WO2010151872A1 (fr) * | 2009-06-26 | 2010-12-29 | Toray Plastics (America) , Inc. | Film d'acide polylactique à orientation biaxiale à barrière contre l'humidité améliorée |
| CN102039664B (zh) * | 2009-10-10 | 2013-11-27 | E.I.内穆尔杜邦公司 | 多层膜的叠合方法和用该方法制成的太阳能电池背板 |
| PT2558133T (pt) | 2010-03-26 | 2020-04-23 | Tepha Inc | Revestimentos para o fabrico e aplicação de dispositivos médicos de polihidroxialcanqato |
| US10227718B2 (en) | 2010-06-15 | 2019-03-12 | Tepha, Inc. | Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers |
| CA2813599A1 (fr) | 2010-10-06 | 2012-04-12 | Ams Research Corporation | Implants comprenant des elements absorbables et non-absorbables destines a traiter des etats pathologiques relatifs au pelvis chez la femme |
| ES2644478T3 (es) | 2010-11-09 | 2017-11-29 | Tepha, Inc. | Implantes cocleares liberadores de fármacos |
| US8579990B2 (en) * | 2011-03-30 | 2013-11-12 | Ethicon, Inc. | Tissue repair devices of rapid therapeutic absorbency |
| WO2012142100A1 (fr) | 2011-04-13 | 2012-10-18 | Metabolix, Inc. | Films multicouches co-extrudés biodégradables |
| WO2013024355A1 (fr) * | 2011-08-16 | 2013-02-21 | Synthes Usa, Llc | Article multicouche thermoplastique |
| DE102012202822A1 (de) | 2012-02-24 | 2013-08-29 | Tesa Se | Biologisch abbaubarer Haftklebstoff |
| EP2852417B1 (fr) | 2012-05-21 | 2019-06-12 | Tepha, Inc. | Compositions de biocéramique résorbable de poly-4-hydroxybutyrate et leurs copolymères |
| US9205456B2 (en) | 2012-07-24 | 2015-12-08 | Abbott Cardiovascular Systems Inc. | Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds |
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- 2014-12-18 CA CA2933746A patent/CA2933746C/fr active Active
- 2014-12-18 WO PCT/US2014/071073 patent/WO2015100120A1/fr not_active Ceased
- 2014-12-18 US US14/574,649 patent/US11154642B2/en active Active
- 2014-12-18 EP EP14824715.8A patent/EP3086820B1/fr active Active
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2021
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015100120A1 (fr) | 2015-07-02 |
| US11154642B2 (en) | 2021-10-26 |
| EP3086820A1 (fr) | 2016-11-02 |
| CA2933746A1 (fr) | 2015-07-02 |
| CA2933746C (fr) | 2018-12-04 |
| US20150182670A1 (en) | 2015-07-02 |
| US20220096716A1 (en) | 2022-03-31 |
| EP3086820B1 (fr) | 2020-10-28 |
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