ES2841136T8 - Péptidos cíclicos de unión a beta-amiloides y sus usos - Google Patents

Péptidos cíclicos de unión a beta-amiloides y sus usos

Info

Publication number
ES2841136T8
ES2841136T8 ES14799656T ES14799656T ES2841136T8 ES 2841136 T8 ES2841136 T8 ES 2841136T8 ES 14799656 T ES14799656 T ES 14799656T ES 14799656 T ES14799656 T ES 14799656T ES 2841136 T8 ES2841136 T8 ES 2841136T8
Authority
ES
Spain
Prior art keywords
binding peptides
amyloid binding
cyclic beta
beta
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14799656T
Other languages
English (en)
Other versions
ES2841136T3 (es
Inventor
Dieter Willbold
Oleksandr Brener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Priavoid GmbH
Original Assignee
Priavoid GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Priavoid GmbH filed Critical Priavoid GmbH
Application granted granted Critical
Publication of ES2841136T3 publication Critical patent/ES2841136T3/es
Publication of ES2841136T8 publication Critical patent/ES2841136T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
ES14799656T 2013-09-26 2014-09-23 Péptidos cíclicos de unión a beta-amiloides y sus usos Active ES2841136T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102013016002.2A DE102013016002A1 (de) 2013-09-26 2013-09-26 Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung
PCT/DE2014/000476 WO2015043566A1 (de) 2013-09-26 2014-09-23 Zyklische, amyloid-beta-bindende peptide und deren verwendung

Publications (2)

Publication Number Publication Date
ES2841136T3 ES2841136T3 (es) 2021-07-07
ES2841136T8 true ES2841136T8 (es) 2022-02-09

Family

ID=51904540

Family Applications (2)

Application Number Title Priority Date Filing Date
ES14799656T Active ES2841136T3 (es) 2013-09-26 2014-09-23 Péptidos cíclicos de unión a beta-amiloides y sus usos
ES20203813T Active ES2953857T3 (es) 2013-09-26 2014-09-23 Péptidos cíclicos de unión a beta-amiloides y sus usos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES20203813T Active ES2953857T3 (es) 2013-09-26 2014-09-23 Péptidos cíclicos de unión a beta-amiloides y sus usos

Country Status (8)

Country Link
US (1) US10428127B2 (es)
EP (2) EP3049153B8 (es)
JP (2) JP6590794B2 (es)
CN (1) CN105745220B (es)
DE (1) DE102013016002A1 (es)
DK (1) DK3049153T3 (es)
ES (2) ES2841136T3 (es)
WO (1) WO2015043566A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102015003676A1 (de) * 2015-03-20 2016-09-22 Forschungszentrum Jülich GmbH Fachbereich Patente Spezifisch A-Beta Spezies bindende Peptide für die Therapie und/oder die Diagnose der Alzheimerschen Demenz
DE102016125645A1 (de) * 2016-12-23 2018-06-28 Forschungszentrum Jülich GmbH D-enantiomere Peptide zur Therapie von chronischem und neuropathischem Schmerz
CN106866792B (zh) * 2017-02-24 2020-09-04 中山大学 一类环十肽分子及其应用
DE102017010455A1 (de) * 2017-06-13 2018-12-13 Forschungszentrum Jülich GmbH Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe
DE102018110543A1 (de) * 2018-05-03 2019-11-07 Forschungszentrum Jülich GmbH D-enantiomere Peptide zur anti-inflammatorischen Behandlung der Amyotrophen Lateralsklerose (ALS) und anderer von neuro-inflammation getriebener Erkrankungen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1141250B1 (en) 1998-12-18 2006-03-01 The Penn State Research Foundation Intein-mediated cyclization of peptides
JP2004513873A (ja) * 1999-11-05 2004-05-13 アクソニックス,インコーポレイティド アミロイド、アミロイド様沈着物またはそれらのβ−シートリッチな病理前駆体への異常タンパク質折り畳みに関係する疾患の治療における生体内使用に適するペプチド類似物および模倣物
DE10117281A1 (de) 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
DE102005049537B4 (de) 2005-10-17 2010-04-22 Forschungszentrum Karlsruhe Gmbh Verfahren zur Herstellung zyklischer Peptide und Verwendung der derart hergestellten zyklischen Peptide
CN101454671A (zh) 2006-03-31 2009-06-10 加利福尼亚大学董事会 用于治疗神经变性疾病和阿尔茨海默病以及改善正常记忆的方法和组合物
WO2010041252A2 (en) * 2008-10-07 2010-04-15 Ramot At Tel-Aviv University Ltd. Use of a cinnamon bark extract for treating amyloid-associated diseases
DE102008037564A1 (de) 2008-11-19 2010-05-20 Forschungszentrum Jülich GmbH Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden
US8906355B2 (en) 2009-10-29 2014-12-09 Lucia Irene Gonzalez Synthetic stereoisomer peptides in the retro-inverso and inverso configuration, and with cyclic and linear structure, their polymer conjugates, their encapsulation in polymer particles, and uses thereof
US9504759B2 (en) 2011-08-11 2016-11-29 Bar-Ilan University Surface modified proteinaceous spherical particles and uses thereof
DE102012102998B4 (de) * 2012-04-05 2013-12-05 Forschungszentrum Jülich GmbH Polymere, enthaltend multivalente Amyloid-Beta-bindende D-Peptide und deren Verwendung
CN108926749A (zh) 2012-04-05 2018-12-04 于利希研究中心有限公司 处理血液、血液产品和器官的方法
DK2834644T3 (da) * 2012-04-05 2019-11-04 Forschungszentrum Juelich Gmbh Polymerer, indeholdende multivalente amyloid-beta-bindende d-peptider og deres anvendelse
DE102012102999A1 (de) 2012-04-05 2013-10-10 Forschungszentrum Jülich GmbH Verfahren zur Behandlung von Blut, Blutprodukten und Organen
WO2014177127A1 (de) * 2013-04-30 2014-11-06 Forschungszentrum Jülich GmbH Agenzien zur prävention und therapie von hiv und anderer viraler infektionen

Also Published As

Publication number Publication date
JP2016538241A (ja) 2016-12-08
JP6590794B2 (ja) 2019-10-16
EP3797787C0 (de) 2023-06-07
ES2841136T3 (es) 2021-07-07
CN105745220A (zh) 2016-07-06
EP3797787A1 (de) 2021-03-31
EP3797787B9 (de) 2023-10-04
EP3797787B1 (de) 2023-06-07
EP3049153B8 (de) 2021-03-17
DE102013016002A1 (de) 2015-03-26
EP3049153B1 (de) 2020-10-28
US20180111971A1 (en) 2018-04-26
JP2020023510A (ja) 2020-02-13
CN105745220B (zh) 2020-03-27
EP3049153A1 (de) 2016-08-03
DK3049153T3 (da) 2021-01-11
US10428127B2 (en) 2019-10-01
WO2015043566A1 (de) 2015-04-02
WO2015043566A8 (de) 2016-06-02
ES2953857T3 (es) 2023-11-16

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