ES2841136T8 - Péptidos cíclicos de unión a beta-amiloides y sus usos - Google Patents
Péptidos cíclicos de unión a beta-amiloides y sus usosInfo
- Publication number
- ES2841136T8 ES2841136T8 ES14799656T ES14799656T ES2841136T8 ES 2841136 T8 ES2841136 T8 ES 2841136T8 ES 14799656 T ES14799656 T ES 14799656T ES 14799656 T ES14799656 T ES 14799656T ES 2841136 T8 ES2841136 T8 ES 2841136T8
- Authority
- ES
- Spain
- Prior art keywords
- binding peptides
- amyloid binding
- cyclic beta
- beta
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013016002.2A DE102013016002A1 (de) | 2013-09-26 | 2013-09-26 | Zyklische, Amyloid-Beta-bindende Peptide und deren Verwendung |
| PCT/DE2014/000476 WO2015043566A1 (de) | 2013-09-26 | 2014-09-23 | Zyklische, amyloid-beta-bindende peptide und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2841136T3 ES2841136T3 (es) | 2021-07-07 |
| ES2841136T8 true ES2841136T8 (es) | 2022-02-09 |
Family
ID=51904540
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14799656T Active ES2841136T3 (es) | 2013-09-26 | 2014-09-23 | Péptidos cíclicos de unión a beta-amiloides y sus usos |
| ES20203813T Active ES2953857T3 (es) | 2013-09-26 | 2014-09-23 | Péptidos cíclicos de unión a beta-amiloides y sus usos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES20203813T Active ES2953857T3 (es) | 2013-09-26 | 2014-09-23 | Péptidos cíclicos de unión a beta-amiloides y sus usos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10428127B2 (es) |
| EP (2) | EP3049153B8 (es) |
| JP (2) | JP6590794B2 (es) |
| CN (1) | CN105745220B (es) |
| DE (1) | DE102013016002A1 (es) |
| DK (1) | DK3049153T3 (es) |
| ES (2) | ES2841136T3 (es) |
| WO (1) | WO2015043566A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102015003676A1 (de) * | 2015-03-20 | 2016-09-22 | Forschungszentrum Jülich GmbH Fachbereich Patente | Spezifisch A-Beta Spezies bindende Peptide für die Therapie und/oder die Diagnose der Alzheimerschen Demenz |
| DE102016125645A1 (de) * | 2016-12-23 | 2018-06-28 | Forschungszentrum Jülich GmbH | D-enantiomere Peptide zur Therapie von chronischem und neuropathischem Schmerz |
| CN106866792B (zh) * | 2017-02-24 | 2020-09-04 | 中山大学 | 一类环十肽分子及其应用 |
| DE102017010455A1 (de) * | 2017-06-13 | 2018-12-13 | Forschungszentrum Jülich GmbH | Verfahren zum Nachweis von Aggregaten biotherapeutischer Substanzen in einer Probe |
| DE102018110543A1 (de) * | 2018-05-03 | 2019-11-07 | Forschungszentrum Jülich GmbH | D-enantiomere Peptide zur anti-inflammatorischen Behandlung der Amyotrophen Lateralsklerose (ALS) und anderer von neuro-inflammation getriebener Erkrankungen |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1141250B1 (en) | 1998-12-18 | 2006-03-01 | The Penn State Research Foundation | Intein-mediated cyclization of peptides |
| JP2004513873A (ja) * | 1999-11-05 | 2004-05-13 | アクソニックス,インコーポレイティド | アミロイド、アミロイド様沈着物またはそれらのβ−シートリッチな病理前駆体への異常タンパク質折り畳みに関係する疾患の治療における生体内使用に適するペプチド類似物および模倣物 |
| DE10117281A1 (de) | 2001-04-06 | 2002-10-24 | Inst Molekulare Biotechnologie | Peptid zur Diagnose und Therapie der Alzheimer-Demenz |
| DE102005049537B4 (de) | 2005-10-17 | 2010-04-22 | Forschungszentrum Karlsruhe Gmbh | Verfahren zur Herstellung zyklischer Peptide und Verwendung der derart hergestellten zyklischen Peptide |
| CN101454671A (zh) | 2006-03-31 | 2009-06-10 | 加利福尼亚大学董事会 | 用于治疗神经变性疾病和阿尔茨海默病以及改善正常记忆的方法和组合物 |
| WO2010041252A2 (en) * | 2008-10-07 | 2010-04-15 | Ramot At Tel-Aviv University Ltd. | Use of a cinnamon bark extract for treating amyloid-associated diseases |
| DE102008037564A1 (de) | 2008-11-19 | 2010-05-20 | Forschungszentrum Jülich GmbH | Zusammensetzung zur Herstellung von anti-Amyloid beta-Peptid-Antikörpern mit D-Peptiden |
| US8906355B2 (en) | 2009-10-29 | 2014-12-09 | Lucia Irene Gonzalez | Synthetic stereoisomer peptides in the retro-inverso and inverso configuration, and with cyclic and linear structure, their polymer conjugates, their encapsulation in polymer particles, and uses thereof |
| US9504759B2 (en) | 2011-08-11 | 2016-11-29 | Bar-Ilan University | Surface modified proteinaceous spherical particles and uses thereof |
| DE102012102998B4 (de) * | 2012-04-05 | 2013-12-05 | Forschungszentrum Jülich GmbH | Polymere, enthaltend multivalente Amyloid-Beta-bindende D-Peptide und deren Verwendung |
| CN108926749A (zh) | 2012-04-05 | 2018-12-04 | 于利希研究中心有限公司 | 处理血液、血液产品和器官的方法 |
| DK2834644T3 (da) * | 2012-04-05 | 2019-11-04 | Forschungszentrum Juelich Gmbh | Polymerer, indeholdende multivalente amyloid-beta-bindende d-peptider og deres anvendelse |
| DE102012102999A1 (de) | 2012-04-05 | 2013-10-10 | Forschungszentrum Jülich GmbH | Verfahren zur Behandlung von Blut, Blutprodukten und Organen |
| WO2014177127A1 (de) * | 2013-04-30 | 2014-11-06 | Forschungszentrum Jülich GmbH | Agenzien zur prävention und therapie von hiv und anderer viraler infektionen |
-
2013
- 2013-09-26 DE DE102013016002.2A patent/DE102013016002A1/de not_active Withdrawn
-
2014
- 2014-09-23 JP JP2016517293A patent/JP6590794B2/ja active Active
- 2014-09-23 US US15/022,712 patent/US10428127B2/en active Active
- 2014-09-23 WO PCT/DE2014/000476 patent/WO2015043566A1/de not_active Ceased
- 2014-09-23 ES ES14799656T patent/ES2841136T3/es active Active
- 2014-09-23 EP EP14799656.5A patent/EP3049153B8/de active Active
- 2014-09-23 DK DK14799656.5T patent/DK3049153T3/da active
- 2014-09-23 CN CN201480053082.4A patent/CN105745220B/zh active Active
- 2014-09-23 EP EP20203813.9A patent/EP3797787B9/de active Active
- 2014-09-23 ES ES20203813T patent/ES2953857T3/es active Active
-
2019
- 2019-09-26 JP JP2019175332A patent/JP2020023510A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016538241A (ja) | 2016-12-08 |
| JP6590794B2 (ja) | 2019-10-16 |
| EP3797787C0 (de) | 2023-06-07 |
| ES2841136T3 (es) | 2021-07-07 |
| CN105745220A (zh) | 2016-07-06 |
| EP3797787A1 (de) | 2021-03-31 |
| EP3797787B9 (de) | 2023-10-04 |
| EP3797787B1 (de) | 2023-06-07 |
| EP3049153B8 (de) | 2021-03-17 |
| DE102013016002A1 (de) | 2015-03-26 |
| EP3049153B1 (de) | 2020-10-28 |
| US20180111971A1 (en) | 2018-04-26 |
| JP2020023510A (ja) | 2020-02-13 |
| CN105745220B (zh) | 2020-03-27 |
| EP3049153A1 (de) | 2016-08-03 |
| DK3049153T3 (da) | 2021-01-11 |
| US10428127B2 (en) | 2019-10-01 |
| WO2015043566A1 (de) | 2015-04-02 |
| WO2015043566A8 (de) | 2016-06-02 |
| ES2953857T3 (es) | 2023-11-16 |
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