ES2899779T3 - Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos - Google Patents

Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos Download PDF

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Publication number
ES2899779T3
ES2899779T3 ES15865633T ES15865633T ES2899779T3 ES 2899779 T3 ES2899779 T3 ES 2899779T3 ES 15865633 T ES15865633 T ES 15865633T ES 15865633 T ES15865633 T ES 15865633T ES 2899779 T3 ES2899779 T3 ES 2899779T3
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seq
amino acids
sequence shown
variable region
chain variable
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Spanish (es)
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Renier J Brentjens
Eric L Smith
Cheng Liu
Hong Liu
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Memorial Sloan Kettering Cancer Center
Eureka Therapeutics Inc
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Memorial Sloan Kettering Cancer Center
Eureka Therapeutics Inc
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/0005—Vertebrate antigens
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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ES15865633T 2014-12-05 2015-12-04 Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos Active ES2899779T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462088286P 2014-12-05 2014-12-05
PCT/US2015/064102 WO2016090312A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof

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