ES2970530T3 - Derivados del isocromeno como inhibidores de fosfoinosítido 3-cinasas - Google Patents

Derivados del isocromeno como inhibidores de fosfoinosítido 3-cinasas Download PDF

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Publication number
ES2970530T3
ES2970530T3 ES20711985T ES20711985T ES2970530T3 ES 2970530 T3 ES2970530 T3 ES 2970530T3 ES 20711985 T ES20711985 T ES 20711985T ES 20711985 T ES20711985 T ES 20711985T ES 2970530 T3 ES2970530 T3 ES 2970530T3
Authority
ES
Spain
Prior art keywords
met
amino
razolo
socromen
peraz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20711985T
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English (en)
Spanish (es)
Inventor
Matteo Biagetti
Paolo Ronchi
Claudio Fiorelli
Paolo Bruno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Application granted granted Critical
Publication of ES2970530T3 publication Critical patent/ES2970530T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
ES20711985T 2019-04-04 2020-03-24 Derivados del isocromeno como inhibidores de fosfoinosítido 3-cinasas Active ES2970530T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19167245 2019-04-04
PCT/EP2020/058168 WO2020200918A1 (fr) 2019-04-04 2020-03-24 Dérivés d'isochromène utilisés en tant qu'inhibiteurs de phosphoinositide 3-kinases

Publications (1)

Publication Number Publication Date
ES2970530T3 true ES2970530T3 (es) 2024-05-29

Family

ID=66092138

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20711985T Active ES2970530T3 (es) 2019-04-04 2020-03-24 Derivados del isocromeno como inhibidores de fosfoinosítido 3-cinasas

Country Status (26)

Country Link
US (1) US12527797B2 (fr)
EP (1) EP3947384B1 (fr)
JP (1) JP2022526973A (fr)
KR (1) KR20210149077A (fr)
CN (1) CN113874376A (fr)
AR (1) AR118588A1 (fr)
AU (1) AU2020252904A1 (fr)
BR (1) BR112021019589A2 (fr)
CA (1) CA3135309A1 (fr)
DK (1) DK3947384T3 (fr)
ES (1) ES2970530T3 (fr)
FI (1) FI3947384T3 (fr)
HR (1) HRP20240130T1 (fr)
HU (1) HUE065052T2 (fr)
IL (1) IL286937A (fr)
MA (1) MA55479A (fr)
MX (1) MX2021011979A (fr)
MY (1) MY206575A (fr)
PH (1) PH12021552402A1 (fr)
PL (1) PL3947384T3 (fr)
PT (1) PT3947384T (fr)
SG (1) SG11202110801XA (fr)
SI (1) SI3947384T1 (fr)
TW (1) TW202102504A (fr)
WO (1) WO2020200918A1 (fr)
ZA (1) ZA202107710B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4673213A1 (fr) 2023-03-02 2026-01-07 Chiesi Farmaceutici S.p.A. Dérivés de pyridazinyl amino utilisés en tant qu'inhibiteurs d'alk 5

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
ATE363892T1 (de) 1999-03-05 2007-06-15 Chiesi Farma Spa Verbesserte pulverformulierungen zur inhalation
NZ599830A (en) 2009-11-05 2014-08-29 Rhizen Pharmaceuticals Sa Novel kinase modulators
AR098776A1 (es) * 2013-12-18 2016-06-15 Chiesi Farm Spa Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas
EP3157920B1 (fr) 2014-06-17 2019-08-07 Chiesi Farmaceutici S.p.A. Dérivés d'indolizine en tant qu'inhibiteurs de phosphoinositide 3-kinases
US9745308B2 (en) 2014-09-12 2017-08-29 Chiesi Farmaceutici S.P.A. Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors
US9968604B2 (en) 2015-04-16 2018-05-15 Chiesi Farmaceutici S.P.A. Chromene derivatives as phoshoinositide 3-kinases inhibitors
WO2017134053A1 (fr) 2016-02-04 2017-08-10 Chiesi Farmaceutici S.P.A. Dérivés de pyrazole à utiliser en tant qu'inhibiteurs de phosphoinositide 3-kinases

Also Published As

Publication number Publication date
TW202102504A (zh) 2021-01-16
BR112021019589A2 (pt) 2021-12-07
AU2020252904A1 (en) 2021-11-18
HUE065052T2 (hu) 2024-04-28
MX2021011979A (es) 2021-11-03
AR118588A1 (es) 2021-10-20
US20220175784A1 (en) 2022-06-09
US12527797B2 (en) 2026-01-20
ZA202107710B (en) 2025-03-26
DK3947384T3 (da) 2024-01-08
KR20210149077A (ko) 2021-12-08
CN113874376A (zh) 2021-12-31
SI3947384T1 (sl) 2024-03-29
JP2022526973A (ja) 2022-05-27
HRP20240130T1 (hr) 2024-04-12
MA55479A (fr) 2022-02-09
PL3947384T3 (pl) 2024-03-25
PT3947384T (pt) 2024-01-29
EP3947384B1 (fr) 2023-11-01
WO2020200918A1 (fr) 2020-10-08
FI3947384T3 (fi) 2024-01-30
IL286937A (en) 2021-10-31
MY206575A (en) 2024-12-24
SG11202110801XA (en) 2021-10-28
EP3947384A1 (fr) 2022-02-09
CA3135309A1 (fr) 2020-10-08
PH12021552402A1 (en) 2022-06-20

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