ES2995084T3 - Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound - Google Patents
Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound Download PDFInfo
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- ES2995084T3 ES2995084T3 ES21741236T ES21741236T ES2995084T3 ES 2995084 T3 ES2995084 T3 ES 2995084T3 ES 21741236 T ES21741236 T ES 21741236T ES 21741236 T ES21741236 T ES 21741236T ES 2995084 T3 ES2995084 T3 ES 2995084T3
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 152
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 84
- 101100135868 Dictyostelium discoideum pde3 gene Proteins 0.000 title claims abstract description 17
- 229940125436 dual inhibitor Drugs 0.000 title description 2
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
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- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 9
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- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 claims description 2
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010042865 | 2020-01-15 | ||
| PCT/CN2021/072145 WO2021143841A1 (zh) | 2020-01-15 | 2021-01-15 | 三并环类pde3/pde4双重抑制剂化合物的药物组合物 |
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| ES2995084T3 true ES2995084T3 (en) | 2025-02-05 |
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| ES21741236T Active ES2995084T3 (en) | 2020-01-15 | 2021-01-15 | Pharmaceutical composition of tricyclic pde3/pde4 dual inhibitor compound |
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| EP (1) | EP4092025B9 (pl) |
| JP (2) | JP7712276B2 (pl) |
| KR (1) | KR20220127845A (pl) |
| CN (3) | CN119909076A (pl) |
| CA (1) | CA3167378A1 (pl) |
| ES (1) | ES2995084T3 (pl) |
| PL (1) | PL4092025T3 (pl) |
| WO (1) | WO2021143841A1 (pl) |
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| PL4092025T3 (pl) * | 2020-01-15 | 2024-10-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Kompozycja farmaceutyczna tricyklicznego związku będącego podwójnym inhibitorem pde3/pde4 |
| CN114929701B (zh) * | 2020-01-15 | 2024-11-05 | 正大天晴药业集团股份有限公司 | 一种pde3/pde4双重抑制剂的结晶及其应用 |
| US20250171436A1 (en) * | 2022-01-21 | 2025-05-29 | Xizang Haisco Pharmaceutical Co., Ltd. | Tricyclic Fused Heterocyclic PDE3/4 Dual Inhibitor and Use Thereof |
| CN118105342A (zh) * | 2023-09-28 | 2024-05-31 | 立生医药(苏州)有限公司 | 一种含pde-4抑制剂的无菌吸入用混悬液及其制备方法和应用 |
| CN120136868A (zh) * | 2023-12-13 | 2025-06-13 | 石家庄以岭药业股份有限公司 | 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用 |
| WO2026052051A1 (zh) * | 2024-09-06 | 2026-03-12 | 正大天晴药业集团股份有限公司 | 杂环化合物在治疗肺疾病中的应用 |
| WO2026158380A1 (zh) * | 2025-01-21 | 2026-07-30 | 正大天晴药业集团股份有限公司 | 含三并环的化合物的药物组合物 |
| WO2025149100A2 (zh) * | 2025-04-29 | 2025-07-17 | 北京泰德制药股份有限公司 | 含有pde4抑制剂化合物a的药物组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| ZW6284A1 (en) * | 1983-05-05 | 1985-10-30 | Hoffmann La Roche | Novel pyrimidone derivatives |
| US6473627B1 (en) | 1998-07-22 | 2002-10-29 | Mitsubishi Denki Kabushiki Kaisha | Mobile communication system and mobile communication method |
| DK1165558T3 (da) | 1999-03-31 | 2004-02-09 | Vernalis Ltd | Pyrimido[6,1-a]isoquinolin-4-on-derivater |
| CN101262846A (zh) * | 2005-07-15 | 2008-09-10 | Map药物公司 | 在离散的吸入粒子中结合的多种活性药物成分及其制剂 |
| SI2603509T1 (sl) * | 2010-08-09 | 2014-10-30 | Verona Pharma Plc | Kristalinična oblika spojine PIRIMIDIO(6,1-A) IZOKINOLIN-4-ENA |
| JP6560986B2 (ja) * | 2013-03-15 | 2019-08-14 | ヴェローナ ファーマ ピーエルシー | 複合製剤 |
| LT3193835T (lt) * | 2014-09-15 | 2018-06-11 | Verona Pharma Plc | Skysta inhaliuojama vaisto forma, apimanti rpl554 |
| GB201502260D0 (en) * | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
| FI3822272T3 (fi) * | 2018-07-13 | 2025-01-21 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Fuusioitunut trisyklinen yhdiste PDE3:n/PDE4:n kaksoisinhibiittorina |
| PL4092025T3 (pl) * | 2020-01-15 | 2024-10-28 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Kompozycja farmaceutyczna tricyklicznego związku będącego podwójnym inhibitorem pde3/pde4 |
| CN114929701B (zh) * | 2020-01-15 | 2024-11-05 | 正大天晴药业集团股份有限公司 | 一种pde3/pde4双重抑制剂的结晶及其应用 |
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2021
- 2021-01-15 PL PL21741236.0T patent/PL4092025T3/pl unknown
- 2021-01-15 WO PCT/CN2021/072145 patent/WO2021143841A1/zh not_active Ceased
- 2021-01-15 US US17/792,282 patent/US20230060174A1/en active Pending
- 2021-01-15 JP JP2022543589A patent/JP7712276B2/ja active Active
- 2021-01-15 CA CA3167378A patent/CA3167378A1/en active Pending
- 2021-01-15 CN CN202411808682.9A patent/CN119909076A/zh active Pending
- 2021-01-15 CN CN202180008484.2A patent/CN114929700B/zh active Active
- 2021-01-15 KR KR1020227026829A patent/KR20220127845A/ko active Pending
- 2021-01-15 EP EP21741236.0A patent/EP4092025B9/en active Active
- 2021-01-15 CN CN202411808686.7A patent/CN119792296A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2025148464A (ja) | 2025-10-07 |
| US20230060174A1 (en) | 2023-03-02 |
| WO2021143841A1 (zh) | 2021-07-22 |
| EP4092025A4 (en) | 2023-08-30 |
| EP4092025B1 (en) | 2024-08-14 |
| AU2021208129A1 (en) | 2022-08-18 |
| CN119792296A (zh) | 2025-04-11 |
| CA3167378A1 (en) | 2021-07-22 |
| CN114929700B (zh) | 2024-11-22 |
| KR20220127845A (ko) | 2022-09-20 |
| JP7712276B2 (ja) | 2025-07-23 |
| EP4092025A1 (en) | 2022-11-23 |
| CN119909076A (zh) | 2025-05-02 |
| EP4092025B9 (en) | 2024-11-06 |
| CN114929700A (zh) | 2022-08-19 |
| JP2023512475A (ja) | 2023-03-27 |
| PL4092025T3 (pl) | 2024-10-28 |
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