ES3063931T3 - Compositions containing thymohydroquinone and their method of preparation - Google Patents

Compositions containing thymohydroquinone and their method of preparation

Info

Publication number
ES3063931T3
ES3063931T3 ES18893434T ES18893434T ES3063931T3 ES 3063931 T3 ES3063931 T3 ES 3063931T3 ES 18893434 T ES18893434 T ES 18893434T ES 18893434 T ES18893434 T ES 18893434T ES 3063931 T3 ES3063931 T3 ES 3063931T3
Authority
ES
Spain
Prior art keywords
thymohydroquinone
preparation
compositions containing
nigella sativa
hederin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES18893434T
Other languages
English (en)
Inventor
Muhammed Majeed
Kalyanam Nagabhushanam
Beena Bhat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sami Sabinsa Group Ltd
Original Assignee
Sami Sabinsa Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sami Sabinsa Group Ltd filed Critical Sami Sabinsa Group Ltd
Application granted granted Critical
Publication of ES3063931T3 publication Critical patent/ES3063931T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)

Abstract

Se describen composiciones enriquecidas con timohidroquinona, que comprenden además timoquinona, hederagenina y/o α-hederina, formuladas mediante la mezcla de moléculas activas aisladas de las semillas de Nigella sativa. Asimismo, se describen nuevos procesos para el aislamiento de los componentes bioactivos timohidroquinona y timoquinona de las semillas de Nigella sativa. También se describe un proceso para el aislamiento de α-hederina y hederagenina a partir del material residual de Nigella sativa. (Traducción automática con Google Translate, sin valor legal)
ES18893434T 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation Active ES3063931T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762610565P 2017-12-27 2017-12-27
PCT/US2018/067478 WO2019133587A1 (en) 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation

Publications (1)

Publication Number Publication Date
ES3063931T3 true ES3063931T3 (en) 2026-04-21

Family

ID=66949194

Family Applications (2)

Application Number Title Priority Date Filing Date
ES18893434T Active ES3063931T3 (en) 2017-12-27 2018-12-26 Compositions containing thymohydroquinone and their method of preparation
ES18897769T Active ES3027618T3 (en) 2017-12-27 2018-12-26 Thymohydroquinone for use in treating hyperglycemia

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES18897769T Active ES3027618T3 (en) 2017-12-27 2018-12-26 Thymohydroquinone for use in treating hyperglycemia

Country Status (13)

Country Link
US (2) US10945969B2 (es)
EP (2) EP3731833B1 (es)
JP (2) JP7012857B2 (es)
KR (2) KR102539298B1 (es)
CN (2) CN111566218B (es)
AU (2) AU2018397667B2 (es)
BR (1) BR112020012949A2 (es)
CA (2) CA3087050C (es)
EA (2) EA202091205A1 (es)
ES (2) ES3063931T3 (es)
PL (1) PL3732294T3 (es)
WO (2) WO2019133587A1 (es)
ZA (2) ZA202004532B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3138995A1 (en) * 2019-05-07 2020-11-12 Lynxit Sport Nutrition As Omega-3 beverage
CN111214514B (zh) * 2020-03-10 2022-03-22 上海中医药大学 续断及续断中活性组分在降糖中的应用
WO2022132844A1 (en) * 2020-12-15 2022-06-23 Muhammed Majeed Anti-viral compositions
JP2023554642A (ja) * 2020-12-17 2023-12-28 サミ－サビンサ グループ リミテッド ビスデメトキシクルクミン組成物の抗肥満能
CN114948915B (zh) * 2022-07-18 2023-10-24 广东省农业科学院动物卫生研究所 百里醌在制备抗副猪嗜血杆菌药物中的应用
EP4593883A1 (en) * 2022-09-29 2025-08-06 Muhammed Majeed Compositions for the management of hirsutism
US20250090614A1 (en) 2023-09-19 2025-03-20 Anju Majeed Compositions and methods for improving lung function

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535740B2 (en) * 2002-11-22 2013-09-17 Bionexus, Ltd. Compositions from Nigella sativa
US8029831B2 (en) * 2008-07-29 2011-10-04 Bionexus, Ltd. Formulations containing thymoquinone for urinary health
WO2005009332A2 (en) * 2003-07-31 2005-02-03 Palsamed (P.B.S.) Ltd. Compositions-of-matter for lowering serum cholesterol and/or triglyceride level and methods of producing and using same
GB0505909D0 (en) * 2005-03-23 2005-04-27 Univ Leeds Formulations
ES2399667T3 (es) * 2006-08-09 2013-04-02 Dsm Ip Assets B.V. Nuevos agentes para el tratamiento de trastornos conectados con neurotransmisión deteriorada
CN101781604A (zh) * 2010-03-11 2010-07-21 南京农业大学 超临界二氧化碳萃取黑种草子油的方法
US20160213727A1 (en) * 2012-01-26 2016-07-28 William G. Rohlfsen Methods and Uses of High Thymoquinone and Thymohydroquinone Essential Oil of Monarda
CN103948604A (zh) * 2014-05-20 2014-07-30 天津理工大学 常春藤皂苷元类化合物作为治疗肝癌药品的应用及其制备
PL412214A1 (pl) 2015-05-04 2016-11-07 Biovico Spółka Z Ograniczoną Odpowiedzialnością Kompozycja roślinna o właściwościach przeciwzapalnych, przeciwalergicznych i/lub przeciwastmatycznych oraz jej zastosowanie

Also Published As

Publication number Publication date
AU2018397667B2 (en) 2021-11-11
EA202091184A1 (ru) 2020-09-23
EP3732294B1 (en) 2025-02-26
KR102539298B1 (ko) 2023-06-02
WO2019133587A1 (en) 2019-07-04
EP3731833A1 (en) 2020-11-04
JP7089033B2 (ja) 2022-06-21
EP3732294A1 (en) 2020-11-04
EP3731833A4 (en) 2021-11-24
BR112020012333A2 (pt) 2020-11-24
JP2021508480A (ja) 2021-03-11
EP3732294A4 (en) 2021-08-18
CN111542313A (zh) 2020-08-14
PL3732294T3 (pl) 2025-06-16
BR112020012949A2 (pt) 2021-01-05
WO2019133588A1 (en) 2019-07-04
CN111566218B (zh) 2023-11-21
KR20200098616A (ko) 2020-08-20
CN111542313B (zh) 2023-11-21
KR102577863B1 (ko) 2023-09-15
ZA202004532B (en) 2021-08-25
JP2021508718A (ja) 2021-03-11
AU2018397668B2 (en) 2022-07-14
ZA202004531B (en) 2022-12-21
JP7012857B2 (ja) 2022-01-28
AU2018397667A1 (en) 2020-07-09
CN111566218A (zh) 2020-08-21
EA202091205A1 (ru) 2020-12-14
US10881623B2 (en) 2021-01-05
CA3087042A1 (en) 2019-07-04
CA3087050A1 (en) 2019-07-04
CA3087050C (en) 2023-09-19
EP3731833B1 (en) 2025-12-10
ES3027618T3 (en) 2025-06-16
CA3087042C (en) 2023-08-01
US20190192448A1 (en) 2019-06-27
US10945969B2 (en) 2021-03-16
US20190192447A1 (en) 2019-06-27
KR20200100772A (ko) 2020-08-26
AU2018397668A1 (en) 2020-07-09

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