ES307300A1 - Procedimiento para la preparacion de nuevos 6,7-benzomorfanos sustituidos. - Google Patents
Procedimiento para la preparacion de nuevos 6,7-benzomorfanos sustituidos.Info
- Publication number
- ES307300A1 ES307300A1 ES0307300A ES307300A ES307300A1 ES 307300 A1 ES307300 A1 ES 307300A1 ES 0307300 A ES0307300 A ES 0307300A ES 307300 A ES307300 A ES 307300A ES 307300 A1 ES307300 A1 ES 307300A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- translation
- preparation
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Discharge Lamp (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33229663A | 1963-12-20 | 1963-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES307300A1 true ES307300A1 (es) | 1965-05-01 |
Family
ID=23297612
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307300A Expired ES307300A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para la preparacion de nuevos 6,7-benzomorfanos sustituidos. |
| ES0307302A Expired ES307302A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para preparar nuevos 6,7-benzomorfanos sustituidos. |
| ES0307299A Expired ES307299A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para la preparacion de 6,7-benzomorfanos sustituidos. |
| ES0307301A Expired ES307301A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para la preparacion de nuevos 6, 7-benzomorfanos sustituidos |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307302A Expired ES307302A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para preparar nuevos 6,7-benzomorfanos sustituidos. |
| ES0307299A Expired ES307299A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para la preparacion de 6,7-benzomorfanos sustituidos. |
| ES0307301A Expired ES307301A1 (es) | 1963-12-20 | 1964-12-19 | Procedimiento para la preparacion de nuevos 6, 7-benzomorfanos sustituidos |
Country Status (12)
| Country | Link |
|---|---|
| AT (4) | AT253687B (fr) |
| BE (2) | BE657406A (fr) |
| CH (7) | CH449643A (fr) |
| DE (2) | DE1445854A1 (fr) |
| DK (4) | DK108495C (fr) |
| ES (4) | ES307300A1 (fr) |
| FR (2) | FR4345M (fr) |
| GB (2) | GB1077711A (fr) |
| IL (2) | IL22642A (fr) |
| NL (3) | NL6414820A (fr) |
| NO (2) | NO119274B (fr) |
| SE (2) | SE322779B (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| AU2003234621A1 (en) | 2002-05-17 | 2003-12-02 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2125750B1 (fr) | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Inhibiteurs d'urée et de carbamate de 11beta-hydroxystéroïde déshydrogénase 1 cycliques |
| US8329897B2 (en) | 2007-07-26 | 2012-12-11 | Vitae Pharmaceuticals, Inc. | Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| EP2220048B1 (fr) | 2007-11-16 | 2017-01-25 | Boehringer Ingelheim International GmbH | Derives aryl et heteroarylcarbonyle de benzomorphanes et de structures d'echafaudage associees, medicaments les contenant et leur utilisation |
| JP5490014B2 (ja) | 2007-12-11 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| EP2252601B1 (fr) | 2008-01-24 | 2012-12-19 | Vitae Pharmaceuticals, Inc. | Carbazate cyclique et inhibiteurs du type semi-carbazide de la 11 -hydroxystéroïde déshydrogénase 1 |
| CA2714532A1 (fr) | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | INHIBITEURS 1,3-OXAZEPAN-2-ONE ET 1,3-DIAZEPAN-2-ONE DE LA 11ß-HYDROXYSTEROIDE DESHYDROGENASE (TYPE1) |
| ATE531696T1 (de) * | 2008-02-12 | 2011-11-15 | Boehringer Ingelheim Int | Harnstoff-derivate von benzomorphanen, entsprechende gerüste, medikamente mit solchen verbindungen und ihre verwendung |
| EP2254872A2 (fr) | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Inhibiteurs de 11beta-hydroxystéroïde deshydrogénase 1 |
| CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| JP5538365B2 (ja) | 2008-05-01 | 2014-07-02 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| CA2722427A1 (fr) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Inhibiteurs cycliques de la 11-beta-hydroxysteroide dehydrogenase 1 |
| EP2291373B1 (fr) | 2008-05-01 | 2013-09-11 | Vitae Pharmaceuticals, Inc. | Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déhydrogénase 1 |
| WO2009138386A2 (fr) | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Dérivés d’acide carboxylique alicyclique de benzomorphanes et échafaudages afférents, médicaments contenant ces composés, et utilisation de ceux-ci |
| RU2539979C2 (ru) | 2008-07-25 | 2015-01-27 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
| JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤 |
| EP2350068B1 (fr) | 2008-10-23 | 2017-08-30 | Boehringer Ingelheim International GmbH | Dérivés d'urée de nortropanes substitués, médicaments contenant de tels composés et leur utilisation |
| WO2010089303A1 (fr) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Inhibiteurs cycliques de la 11β-hydroxystéroïde déshydrogénase de type 1 |
| MA33216B1 (fr) | 2009-04-30 | 2012-04-02 | Boehringer Ingelheim Int | Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1 |
| JP5670440B2 (ja) | 2009-06-02 | 2015-02-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| EP2440537A1 (fr) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 basée sur la structure 1,3-oxazinan-2-one |
| WO2011002910A1 (fr) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Inhibiteurs cycliques de la 11-bêta-hydroxystéroïde déshydrogénase 1 |
| TWI531571B (zh) | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物 |
| EP2582698B1 (fr) | 2010-06-16 | 2016-09-14 | Vitae Pharmaceuticals, Inc. | Hétérocycles à 5, 6 et 7 chaînons substitués, médicaments contenant ces composés et leur utilisation |
| JP5813106B2 (ja) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン |
| BR112013010021A2 (pt) | 2010-11-02 | 2019-09-24 | Boehringer Ingelheim Int | combinações farmacêuticas para o tratamento de distúrbios metabólicos. |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| JP2014524438A (ja) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | インデノピリジン誘導体 |
-
0
- NL NL127995D patent/NL127995C/xx active
-
1964
- 1964-11-30 CH CH1619167A patent/CH449643A/de unknown
- 1964-11-30 CH CH1538364A patent/CH448118A/de unknown
- 1964-11-30 CH CH1618867A patent/CH449640A/de unknown
- 1964-11-30 CH CH1618967A patent/CH449641A/de unknown
- 1964-11-30 CH CH1619067A patent/CH449642A/de unknown
- 1964-11-30 CH CH1538464A patent/CH446371A/de unknown
- 1964-11-30 CH CH1618767A patent/CH449639A/de unknown
- 1964-12-18 AT AT1074364A patent/AT253687B/de active
- 1964-12-18 GB GB5149864A patent/GB1077711A/en not_active Expired
- 1964-12-18 IL IL2264264A patent/IL22642A/xx unknown
- 1964-12-18 NL NL6414820A patent/NL6414820A/xx unknown
- 1964-12-18 AT AT392865A patent/AT249276B/de active
- 1964-12-18 SE SE1536064A patent/SE322779B/xx unknown
- 1964-12-18 GB GB5150064A patent/GB1092394A/en not_active Expired
- 1964-12-18 AT AT392965A patent/AT249277B/de active
- 1964-12-18 DE DE19641445854 patent/DE1445854A1/de active Pending
- 1964-12-18 DE DE19641445853 patent/DE1445853A1/de active Pending
- 1964-12-18 AT AT1074264A patent/AT261126B/de active
- 1964-12-18 IL IL2264364A patent/IL22643A/xx unknown
- 1964-12-18 NL NL6414821A patent/NL6414821A/xx unknown
- 1964-12-18 SE SE1536164A patent/SE305657B/xx unknown
- 1964-12-19 DK DK626764A patent/DK108495C/da active
- 1964-12-19 DK DK626864A patent/DK106552C/da active
- 1964-12-19 ES ES0307300A patent/ES307300A1/es not_active Expired
- 1964-12-19 NO NO15606364A patent/NO119274B/no unknown
- 1964-12-19 ES ES0307302A patent/ES307302A1/es not_active Expired
- 1964-12-19 ES ES0307299A patent/ES307299A1/es not_active Expired
- 1964-12-19 ES ES0307301A patent/ES307301A1/es not_active Expired
- 1964-12-19 DK DK429865A patent/DK108497C/da active
- 1964-12-19 NO NO15606264A patent/NO119273B/no unknown
- 1964-12-19 DK DK429765A patent/DK108496C/da active
- 1964-12-21 BE BE657406D patent/BE657406A/xx unknown
- 1964-12-21 BE BE657405D patent/BE657405A/xx unknown
-
1965
- 1965-03-19 FR FR9865A patent/FR4345M/fr active Active
- 1965-03-19 FR FR9866A patent/FR4346M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| DK106552C (da) | 1967-02-20 |
| ES307301A1 (es) | 1965-05-16 |
| ES307299A1 (es) | 1965-05-16 |
| NL6414820A (fr) | 1965-06-21 |
| CH449642A (de) | 1968-01-15 |
| AT253687B (de) | 1967-04-25 |
| SE322779B (fr) | 1970-04-20 |
| NO119274B (fr) | 1970-04-27 |
| CH449639A (de) | 1968-01-15 |
| DE1445854A1 (de) | 1968-12-05 |
| SE305657B (fr) | 1968-11-04 |
| CH449640A (de) | 1968-01-15 |
| BE657406A (fr) | 1965-06-21 |
| NO119273B (fr) | 1970-04-27 |
| CH448118A (de) | 1967-12-15 |
| GB1077711A (en) | 1967-08-02 |
| DK108496C (da) | 1967-12-27 |
| CH449643A (de) | 1968-01-15 |
| CH449641A (de) | 1968-01-15 |
| DE1445853A1 (de) | 1968-12-05 |
| FR4346M (fr) | 1966-08-16 |
| AT261126B (de) | 1968-04-10 |
| IL22642A (en) | 1968-07-25 |
| GB1092394A (en) | 1967-11-22 |
| NL6414821A (fr) | 1965-06-21 |
| DK108495C (da) | 1967-12-27 |
| NL127995C (fr) | |
| AT249276B (de) | 1966-09-12 |
| CH446371A (de) | 1967-11-15 |
| FR4345M (fr) | 1966-08-16 |
| AT249277B (de) | 1966-09-12 |
| IL22643A (en) | 1968-07-25 |
| BE657405A (fr) | 1965-06-21 |
| DK108497C (da) | 1967-12-27 |
| ES307302A1 (es) | 1965-05-16 |
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