ES307300A1 - Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES307300A1 ES307300A1 ES0307300A ES307300A ES307300A1 ES 307300 A1 ES307300 A1 ES 307300A1 ES 0307300 A ES0307300 A ES 0307300A ES 307300 A ES307300 A ES 307300A ES 307300 A1 ES307300 A1 ES 307300A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- translation
- preparation
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Discharge Lamp (AREA)
Abstract
Process for the preparation of new substituted 6,7-benzomorpans of the general formula I ** (See formula) ** in which X means oxygen or sulfur, R1 means hydrogen, the hydroxyl group, an alkoxy or lower alkanoyloxy radical, R 2 means hydrogen, an alkyl or lower beta-methoxyethyl radical or a phenyl radical optionally substituted by a halogen atom, a hydroxyl group or an alkyl, alkanoyloxy or lower alkoxy group, R3 means hydrogen or a lower alkyl radical, R4 means, hydrogen, a lower alkyl radical, a lower alkenyl radical, a phenyl, chlorophenyl or bromophenyl radical or a phenylalkyl radical, and its acid addition salts, characterized in that a compound of the general formula II, ** (See formula) ** wherein R1, R2 and R3 have the significance indicated in formula I, is reacted with a compound of the general formula III R4+N=C=X where X and R4 have the same significance indicated in formula I, and, if desired, the compound thus obtained is transformed into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33229663A | 1963-12-20 | 1963-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES307300A1 true ES307300A1 (en) | 1965-05-01 |
Family
ID=23297612
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307299A Expired ES307299A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307302A Expired ES307302A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307300A Expired ES307300A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307301A Expired ES307301A1 (en) | 1963-12-20 | 1964-12-19 | Benzomorphans and process for their preparation |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307299A Expired ES307299A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
| ES0307302A Expired ES307302A1 (en) | 1963-12-20 | 1964-12-19 | Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0307301A Expired ES307301A1 (en) | 1963-12-20 | 1964-12-19 | Benzomorphans and process for their preparation |
Country Status (12)
| Country | Link |
|---|---|
| AT (4) | AT249276B (en) |
| BE (2) | BE657406A (en) |
| CH (7) | CH446371A (en) |
| DE (2) | DE1445854A1 (en) |
| DK (4) | DK108495C (en) |
| ES (4) | ES307299A1 (en) |
| FR (2) | FR4345M (en) |
| GB (2) | GB1092394A (en) |
| IL (2) | IL22643A (en) |
| NL (3) | NL6414820A (en) |
| NO (2) | NO119274B (en) |
| SE (2) | SE322779B (en) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2987788A1 (en) | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| CA2678577A1 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| EP2183228B1 (en) | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
| AR069207A1 (en) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1 |
| CL2008003407A1 (en) | 2007-11-16 | 2010-01-11 | Boehringer Ingelheim Int | Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1. |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| WO2009094169A1 (en) | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| JP5734666B2 (en) | 2008-02-11 | 2015-06-17 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | 1,3-oxaazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| CA2711757C (en) * | 2008-02-12 | 2016-07-26 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8598160B2 (en) | 2008-02-15 | 2013-12-03 | Vitae Pharmaceuticals, Inc. | Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| AR071236A1 (en) | 2008-05-01 | 2010-06-02 | Vitae Pharmaceuticals Inc | CYCLE INHIBITORS OF 11BETA-HYDROXIESTEROID DEHYDROGENASE 1 |
| CA2723032A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CL2009001059A1 (en) | 2008-05-01 | 2010-11-12 | Boehringer Ingelheim Int | Compounds derived from substituted 1,3-oxazin-2-one-3.6, inhibitors of the activity of 11-beta-hydroxysteroid dehydrogenase i; pharmaceutical composition that includes them; Useful in the treatment of diseases such as diabetes mellitus, among others. |
| WO2009134387A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| US8846668B2 (en) | 2008-07-25 | 2014-09-30 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| AR073920A1 (en) | 2008-10-23 | 2010-12-09 | Boehringer Ingelheim Int | UREA DERIVATIVES OF SUBSTITUTED NORTROPANS, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE 11BETA-HYDROXIESTEROID DISHYDROGENASE DISEASE AND PROCESS FOR PREPARATION. |
| CA2744946A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| UA109255C2 (en) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010139673A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| AR078887A1 (en) | 2009-11-06 | 2011-12-07 | Boehringer Ingelheim Int | ARILO AND HETEROARILCARBONILO DERIVATIVES OF HEXAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| JP5813106B2 (en) | 2010-06-25 | 2015-11-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Azaspirohexanone as an inhibitor of 11-β-HSD1 for the treatment of metabolic disorders |
| PH12013500808A1 (en) | 2010-11-02 | 2015-10-07 | Boehringer Ingelheim Int | Pharmaceutical combinations for the treatment of metabolic disorders |
| TWI537258B (en) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline |
| JP2014524438A (en) | 2011-08-17 | 2014-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Indenopyridine derivatives |
-
0
- NL NL127995D patent/NL127995C/xx active
-
1964
- 1964-11-30 CH CH1538464A patent/CH446371A/en unknown
- 1964-11-30 CH CH1618967A patent/CH449641A/en unknown
- 1964-11-30 CH CH1618767A patent/CH449639A/en unknown
- 1964-11-30 CH CH1538364A patent/CH448118A/en unknown
- 1964-11-30 CH CH1619067A patent/CH449642A/en unknown
- 1964-11-30 CH CH1618867A patent/CH449640A/en unknown
- 1964-11-30 CH CH1619167A patent/CH449643A/en unknown
- 1964-12-18 NL NL6414820A patent/NL6414820A/xx unknown
- 1964-12-18 DE DE19641445854 patent/DE1445854A1/en active Pending
- 1964-12-18 AT AT392865A patent/AT249276B/en active
- 1964-12-18 GB GB5150064A patent/GB1092394A/en not_active Expired
- 1964-12-18 DE DE19641445853 patent/DE1445853A1/en active Pending
- 1964-12-18 IL IL2264364A patent/IL22643A/en unknown
- 1964-12-18 AT AT1074264A patent/AT261126B/en active
- 1964-12-18 NL NL6414821A patent/NL6414821A/xx unknown
- 1964-12-18 AT AT1074364A patent/AT253687B/en active
- 1964-12-18 IL IL2264264A patent/IL22642A/en unknown
- 1964-12-18 GB GB5149864A patent/GB1077711A/en not_active Expired
- 1964-12-18 SE SE1536064A patent/SE322779B/xx unknown
- 1964-12-18 SE SE1536164A patent/SE305657B/xx unknown
- 1964-12-18 AT AT392965A patent/AT249277B/en active
- 1964-12-19 ES ES0307299A patent/ES307299A1/en not_active Expired
- 1964-12-19 ES ES0307302A patent/ES307302A1/en not_active Expired
- 1964-12-19 ES ES0307300A patent/ES307300A1/en not_active Expired
- 1964-12-19 NO NO15606364A patent/NO119274B/no unknown
- 1964-12-19 DK DK626764A patent/DK108495C/en active
- 1964-12-19 DK DK429865A patent/DK108497C/en active
- 1964-12-19 DK DK626864A patent/DK106552C/en active
- 1964-12-19 ES ES0307301A patent/ES307301A1/en not_active Expired
- 1964-12-19 DK DK429765A patent/DK108496C/en active
- 1964-12-19 NO NO15606264A patent/NO119273B/no unknown
- 1964-12-21 BE BE657406D patent/BE657406A/xx unknown
- 1964-12-21 BE BE657405D patent/BE657405A/xx unknown
-
1965
- 1965-03-19 FR FR9865A patent/FR4345M/fr active Active
- 1965-03-19 FR FR9866A patent/FR4346M/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CH449639A (en) | 1968-01-15 |
| SE305657B (en) | 1968-11-04 |
| CH448118A (en) | 1967-12-15 |
| ES307299A1 (en) | 1965-05-16 |
| DE1445853A1 (en) | 1968-12-05 |
| AT249276B (en) | 1966-09-12 |
| CH446371A (en) | 1967-11-15 |
| ES307302A1 (en) | 1965-05-16 |
| NL6414820A (en) | 1965-06-21 |
| FR4345M (en) | 1966-08-16 |
| GB1092394A (en) | 1967-11-22 |
| SE322779B (en) | 1970-04-20 |
| DK108496C (en) | 1967-12-27 |
| IL22643A (en) | 1968-07-25 |
| NL127995C (en) | |
| BE657406A (en) | 1965-06-21 |
| ES307301A1 (en) | 1965-05-16 |
| CH449641A (en) | 1968-01-15 |
| FR4346M (en) | 1966-08-16 |
| AT253687B (en) | 1967-04-25 |
| IL22642A (en) | 1968-07-25 |
| DK108497C (en) | 1967-12-27 |
| CH449640A (en) | 1968-01-15 |
| NL6414821A (en) | 1965-06-21 |
| AT249277B (en) | 1966-09-12 |
| DK108495C (en) | 1967-12-27 |
| BE657405A (en) | 1965-06-21 |
| GB1077711A (en) | 1967-08-02 |
| DK106552C (en) | 1967-02-20 |
| AT261126B (en) | 1968-04-10 |
| DE1445854A1 (en) | 1968-12-05 |
| NO119273B (en) | 1970-04-27 |
| NO119274B (en) | 1970-04-27 |
| CH449642A (en) | 1968-01-15 |
| CH449643A (en) | 1968-01-15 |
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