ES311042A1 - Un procedimiento para preparar dihidrovimblastina, dihidrovincristina o dihidrodesmetilvinblastina. - Google Patents

Un procedimiento para preparar dihidrovimblastina, dihidrovincristina o dihidrodesmetilvinblastina.

Info

Publication number: ES311042A1
Authority: ES; Spain
Prior art keywords: dihydrovincristine; translation; preparing; machine; legally binding
Prior art date: 1964-04-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES0311042A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-04-01

Filing date

1965-03-26

Publication date

1966-02-01

1965-03-26 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1966-02-01 Publication of ES311042A1 publication Critical patent/ES311042A1/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
CWRJYPJHZKVJAX-UHFFFAOYSA-N dihydrovinblastine Chemical compound C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)CCCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 CWRJYPJHZKVJAX-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229960003048 vinblastine Drugs 0.000 abstract 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 1
229960004528 vincristine Drugs 0.000 abstract 1
OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

ES0311042A 1964-04-01 1965-03-26 Un procedimiento para preparar dihidrovimblastina, dihidrovincristina o dihidrodesmetilvinblastina. Expired ES311042A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US356588A US3352868A (en)	1964-04-01	1964-04-01	Dihydrovinblastine

Publications (1)

Publication Number	Publication Date
ES311042A1 true ES311042A1 (es)	1966-02-01

Family

ID=23402080

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES0311042A Expired ES311042A1 (es)	1964-04-01	1965-03-26	Un procedimiento para preparar dihidrovimblastina, dihidrovincristina o dihidrodesmetilvinblastina.

Country Status (9)

Country	Link
US (1)	US3352868A (de)
BE (1)	BE661948A (de)
BR (1)	BR6568453D0 (de)
CH (1)	CH507264A (de)
DE (1)	DE1545763A1 (de)
ES (1)	ES311042A1 (de)
FR (1)	FR5487M (de)
GB (1)	GB1102224A (de)
SE (1)	SE329630B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4012390A (en) *	1974-10-16	1977-03-15	Eli Lilly And Company	Vinblastinoic acid
US4025522A (en) *	1975-02-07	1977-05-24	Eli Lilly And Company	Conversion of leurosine to vincathicine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
HU178084B (en) *	1977-05-31	1982-03-28	Richter Gedeon Vegyeszet	New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue
FR2461714A1 (fr)	1979-07-17	1981-02-06	Anvar	Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules

1964
- 1964-04-01 US US356588A patent/US3352868A/en not_active Expired - Lifetime
1965
- 1965-03-25 CH CH415665A patent/CH507264A/de not_active IP Right Cessation
- 1965-03-26 ES ES0311042A patent/ES311042A1/es not_active Expired
- 1965-03-29 GB GB13281/65A patent/GB1102224A/en not_active Expired
- 1965-03-31 DE DE19651545763 patent/DE1545763A1/de active Pending
- 1965-03-31 BR BR168453/65A patent/BR6568453D0/pt unknown
- 1965-04-01 FR FR11632A patent/FR5487M/fr not_active Expired
- 1965-04-01 BE BE661948A patent/BE661948A/xx unknown
- 1965-04-01 SE SE04207/65A patent/SE329630B/xx unknown

Also Published As

Publication number	Publication date
GB1102224A (en)	1968-02-07
US3352868A (en)	1967-11-14
DE1545763A1 (de)	1969-10-23
FR5487M (de)	1967-10-30
BE661948A (de)	1965-10-01
CH507264A (de)	1971-05-15
SE329630B (de)	1970-10-19
BR6568453D0 (pt)	1973-07-17

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