ES320261A1 - PROCEDURE FOR OBTAINING A NEW CHEMICAL COMPOUND FOR THE TREATMENT OF CALCIUM DEFICIENCIES - Google Patents
PROCEDURE FOR OBTAINING A NEW CHEMICAL COMPOUND FOR THE TREATMENT OF CALCIUM DEFICIENCIESInfo
- Publication number
- ES320261A1 ES320261A1 ES0320261A ES320261A ES320261A1 ES 320261 A1 ES320261 A1 ES 320261A1 ES 0320261 A ES0320261 A ES 0320261A ES 320261 A ES320261 A ES 320261A ES 320261 A1 ES320261 A1 ES 320261A1
- Authority
- ES
- Spain
- Prior art keywords
- calcium
- galacturonate
- aqueous solution
- glucoheptonate
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052791 calcium Inorganic materials 0.000 title abstract 2
- 239000011575 calcium Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000007812 deficiency Effects 0.000 title 1
- ILJIJWPWFKABMW-PDCYBDDKSA-L D-Galacturonic acid calcium salt Chemical compound [Ca+2].O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C([O-])=O.O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C([O-])=O ILJIJWPWFKABMW-PDCYBDDKSA-L 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 229960002562 calcium glucoheptonate Drugs 0.000 abstract 3
- FATUQANACHZLRT-XBQZYUPDSA-L calcium;(2r,3r,4s,5r,6r)-2,3,4,5,6,7-hexahydroxyheptanoate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)C([O-])=O FATUQANACHZLRT-XBQZYUPDSA-L 0.000 abstract 3
- LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 108010059820 Polygalacturonase Proteins 0.000 abstract 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 abstract 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
- 235000011116 calcium hydroxide Nutrition 0.000 abstract 1
- 239000000920 calcium hydroxide Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 229940124531 pharmaceutical excipient Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
A compound of the formula <FORM:1075270/C2/1> and preparation thereof by mixing equimolecular proportions of calcium glucoheptonate and calcium galacturonate in aqueous solution, heating the mixture to 80 DEG C. then evaporating the bulk of the water and drying the resultant syrup, containing about 70% by weight of the desired product, under a vacuum of 60 mm. of mercury for 1 hr. at a temperature not exceeding 45 DEG C. Calcium glucoheptonate is obtained as an approximately 18% aqueous solution by the action of hydrocyanic acid on D-glucose and treating the intermediate nitrile with slaked lime. Calcium galacturonate is obtained as an approximately 6% aqueous solution by enzymatic hydrolysis of apple pectin using a polygalacturonase to give a double salt of galacturonic acid which is then converted to the calcium salt.ALSO:Pharmaceutical compositions comprise calcium glucohepto-galacturonate of the formula: <FORM:1075270/A5-A6/1> either in solid form, optionally in association with solid pharmaceutical excipients, or in solution and are suitable for oral administration in calcitherapy. The compositions may also include calcium galacturonate and/or calcium glucoheptonate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5308964A GB1075270A (en) | 1964-12-31 | 1964-12-31 | Calcium glucohepto-galacturonate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES320261A1 true ES320261A1 (en) | 1966-09-01 |
Family
ID=10466591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0320261A Expired ES320261A1 (en) | 1964-12-31 | 1965-12-01 | PROCEDURE FOR OBTAINING A NEW CHEMICAL COMPOUND FOR THE TREATMENT OF CALCIUM DEFICIENCIES |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE672883A (en) |
| ES (1) | ES320261A1 (en) |
| FR (1) | FR5210M (en) |
| GB (1) | GB1075270A (en) |
| NL (1) | NL6515828A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2916353B1 (en) * | 2007-05-25 | 2010-09-24 | Univ Picardie | PHARMACEUTICAL COMPOSITION FOR PRESERVING COLLAGEN |
-
1964
- 1964-12-31 GB GB5308964A patent/GB1075270A/en not_active Expired
-
1965
- 1965-11-26 BE BE672883D patent/BE672883A/xx unknown
- 1965-11-29 FR FR40105A patent/FR5210M/fr not_active Expired
- 1965-12-01 ES ES0320261A patent/ES320261A1/en not_active Expired
- 1965-12-06 NL NL6515828A patent/NL6515828A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR5210M (en) | 1967-08-07 |
| BE672883A (en) | 1966-03-16 |
| NL6515828A (en) | 1966-07-04 |
| GB1075270A (en) | 1967-07-12 |
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