ES335706A1 - Procedure for the preparation of derivatives of the theory (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of derivatives of the theory (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES335706A1 ES335706A1 ES0335706A ES335706A ES335706A1 ES 335706 A1 ES335706 A1 ES 335706A1 ES 0335706 A ES0335706 A ES 0335706A ES 335706 A ES335706 A ES 335706A ES 335706 A1 ES335706 A1 ES 335706A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- substituted
- aryloxy
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 125000004104 aryloxy group Chemical group 0.000 abstract 6
- 125000002723 alicyclic group Chemical group 0.000 abstract 5
- 125000000304 alkynyl group Chemical group 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 nicotinoyl Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical group CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 125000001539 acetonyl group Chemical group [H]C([H])([H])C(=O)C([H])([H])* 0.000 abstract 1
- 125000004946 alkenylalkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Process for the preparation of thebaine derivatives of the general formula: ** (See formula) ** where: Q represents one of the radicals: ** (See formula) ** And represents an ethene, -CH = CH- or, when Q is (see formula) u (see formula), an ethane group, -CH2-CH2-; R1 represents a hydrogen atom, a methyl group, an ethyl group, a propyl group, the group CnH2n + 1CO- in which n is an integer from 1 to 3 inclusive, benzoyl or nicotinoyl; R 2 represents a hydrogen atom, an acetonyl group, a phenacyl group, an alkenyl alkyl or alkynyl, whose alkyl, alkenyl and alkynyl groups can contain up to 8 carbon atoms and, what is more, can be substituted on the carbon atoms numbered from 1 to 5 (the atom with the number 1 being adjacent to the nitrogen atom) by alicyclic groups of 4 to 6 carbon atoms, aryl, substituted aryl, alkoxy, aryloxy, substituted aryloxy, heterocyclic, or substituted amino; assuming that when Q = CN, R2 is methyl; R3 represents a hydrogen atom, an alicyclic group containing from 3 to 7 carbon atoms, an alkyl, alkenyl or alkynyl group containing up to 8 carbon atoms whose alkyl, alkenyl and alkynyl groups can be substituted on the carbon atoms numbered in the 1 to 4, the carbon atom of number 1 being adjacent to the carbon atom carrying the oxygen atom, by an alicyclic, aryl, substituted aryl, alkoxy, aryloxy, substituted aryloxy or heterocyclic group; and R4 represents an alicyclic group with 5 to 7 carbon atoms, an alkyl, alkenyl or alkynyl group containing up to 8 carbon atoms which can be substituted on one of its carbon atoms by an alicyclic group, aryl, substituted aryl, alkoxy, aryloxy, substituted aryloxy, heterocyclic or substituted amino assuming that the carbon atom number 1 bonded to the hydroxylic oxygen does not carry a double or triple bond, characterized in that it comprises the operation of reacting with a basic catalyst a compound of the general formula ** (See formula) ** wherein Q, Y, and R2 have the meaning indicated above, so as to produce a compound of one or other of the following general formulas: (see formula) (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2193/66A GB1146271A (en) | 1966-01-17 | 1966-01-17 | Novel thebaine derivatives |
| GB3164666 | 1966-07-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES335706A1 true ES335706A1 (en) | 1967-12-16 |
Family
ID=26237352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0335706A Expired ES335706A1 (en) | 1966-01-17 | 1967-01-16 | Procedure for the preparation of derivatives of the theory (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE692663A (en) |
| ES (1) | ES335706A1 (en) |
| FR (1) | FR7301M (en) |
| GB (1) | GB1146271A (en) |
| GR (1) | GR36358B (en) |
| LU (1) | LU52825A1 (en) |
| NL (1) | NL6700660A (en) |
-
1966
- 1966-01-17 GB GB2193/66A patent/GB1146271A/en not_active Expired
-
1967
- 1967-01-16 ES ES0335706A patent/ES335706A1/en not_active Expired
- 1967-01-16 NL NL6700660A patent/NL6700660A/xx unknown
- 1967-01-16 BE BE692663D patent/BE692663A/xx unknown
- 1967-01-16 LU LU52825D patent/LU52825A1/xx unknown
- 1967-01-17 FR FR91482A patent/FR7301M/fr not_active Expired
- 1967-01-17 GR GR670136358A patent/GR36358B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB1146271A (en) | 1969-03-26 |
| BE692663A (en) | 1967-07-03 |
| FR7301M (en) | 1969-09-29 |
| LU52825A1 (en) | 1967-03-16 |
| GR36358B (en) | 1969-02-03 |
| NL6700660A (en) | 1967-07-18 |
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