ES340820A1 - Procedimiento para la preparacion de derivados de la tiaze-pina. - Google Patents
Procedimiento para la preparacion de derivados de la tiaze-pina.Info
- Publication number
- ES340820A1 ES340820A1 ES340820A ES340820A ES340820A1 ES 340820 A1 ES340820 A1 ES 340820A1 ES 340820 A ES340820 A ES 340820A ES 340820 A ES340820 A ES 340820A ES 340820 A1 ES340820 A1 ES 340820A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- piperazino
- amino
- lower alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000004912 thiazepines Chemical class 0.000 title abstract 2
- WJWDEWXJRCMLMU-UHFFFAOYSA-N benzo[b][1,4]benzoxazepin-6-amine Chemical class NC1=NC2=CC=CC=C2OC2=CC=CC=C12 WJWDEWXJRCMLMU-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 238000005576 amination reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/20—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52086566A | 1966-01-17 | 1966-01-17 | |
| US52089766A | 1966-01-17 | 1966-01-17 | |
| US52084666A | 1966-01-17 | 1966-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES340820A1 true ES340820A1 (es) | 1968-09-16 |
Family
ID=27414773
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES335760A Expired ES335760A1 (es) | 1966-01-17 | 1967-01-17 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340821A Expired ES340821A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340820A Expired ES340820A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES335760A Expired ES335760A1 (es) | 1966-01-17 | 1967-01-17 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
| ES340821A Expired ES340821A1 (es) | 1966-01-17 | 1967-05-22 | Procedimiento para la preparacion de derivados de la tiaze-pina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3444169A (es) |
| JP (1) | JPS5141639B1 (es) |
| AT (1) | AT278805B (es) |
| BE (1) | BE692749A (es) |
| CH (3) | CH504459A (es) |
| DE (1) | DE1645954A1 (es) |
| ES (3) | ES335760A1 (es) |
| FR (2) | FR1508536A (es) |
| IL (2) | IL27143A (es) |
| NL (1) | NL6700663A (es) |
| SE (1) | SE344203B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL140242B (nl) * | 1963-03-01 | 1973-11-15 | Wander Ag Dr A | Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen. |
| GB1192812A (en) * | 1966-05-20 | 1970-05-20 | American Cyanamid Co | 2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts |
| GB1265866A (es) * | 1968-08-23 | 1972-03-08 | ||
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| WO1997016430A1 (en) * | 1995-11-01 | 1997-05-09 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| US6890919B2 (en) * | 2001-06-26 | 2005-05-10 | Shitij Kapur | Atypical antipsychotic agents having low affinity for the D2 receptor |
| US7388954B2 (en) * | 2002-06-24 | 2008-06-17 | Freescale Semiconductor, Inc. | Method and apparatus for tone indication |
| WO2004056182A1 (en) * | 2002-12-20 | 2004-07-08 | Basf Aktiengesellschaft | Pesticidal dibenzo(hetero)azepine derivatives |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| WO2004064753A2 (en) * | 2003-01-23 | 2004-08-05 | Acadia Pharmaceuticals Inc | Use of n-desmethylclozapine to treat human neuropsychiatric disease |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| BRPI0417749A (pt) * | 2003-12-22 | 2007-04-10 | Acadia Pharm Inc | composto, método de sintese de composto, bibliotecas combinatórias, composições farmacêuticas e métodos de tratamento de disfunções neuropsiquiátricas |
| BRPI0509524A (pt) * | 2004-04-01 | 2007-09-18 | Acadia Pharm Inc | formas cristalinas de n-desmetilclozapina |
| EP1937677A1 (en) * | 2005-10-17 | 2008-07-02 | Arcadia Pharmaceuticals Inc. | Cb-1 modulating compounds and their use |
| US20080090805A1 (en) * | 2005-10-17 | 2008-04-17 | Acadia Pharmaceuticals Inc. | Cb-1 modulating compounds and their use |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| CA2728675A1 (en) | 2008-06-20 | 2009-12-23 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH384750A (de) * | 1960-06-08 | 1965-02-26 | Geigy Ag J R | Verfahren zur Herstellung von neuen 2,3 : 6,7-Diareno-1-oxa-4,5-diazepinen |
-
1966
- 1966-01-17 US US520865A patent/US3444169A/en not_active Expired - Lifetime
- 1966-01-17 AT AT00481/67A patent/AT278805B/de not_active IP Right Cessation
- 1966-12-25 IL IL27143A patent/IL27143A/en unknown
- 1966-12-25 IL IL36894A patent/IL36894A/en unknown
-
1967
- 1967-01-16 SE SE604/67A patent/SE344203B/xx unknown
- 1967-01-16 DE DE19671645954 patent/DE1645954A1/de active Pending
- 1967-01-16 NL NL6700663A patent/NL6700663A/xx unknown
- 1967-01-17 CH CH813070A patent/CH504459A/de not_active IP Right Cessation
- 1967-01-17 CH CH1505769A patent/CH495371A/de not_active IP Right Cessation
- 1967-01-17 FR FR91464A patent/FR1508536A/fr not_active Expired
- 1967-01-17 BE BE692749D patent/BE692749A/xx not_active IP Right Cessation
- 1967-01-17 ES ES335760A patent/ES335760A1/es not_active Expired
- 1967-01-17 CH CH60667A patent/CH504458A/de not_active IP Right Cessation
- 1967-01-17 JP JP42003069A patent/JPS5141639B1/ja active Pending
- 1967-04-14 FR FR102738A patent/FR6274M/fr not_active Expired
- 1967-05-22 ES ES340821A patent/ES340821A1/es not_active Expired
- 1967-05-22 ES ES340820A patent/ES340820A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE344203B (es) | 1972-04-04 |
| FR1508536A (fr) | 1968-01-05 |
| IL36894A (en) | 1972-12-29 |
| CH504459A (de) | 1971-03-15 |
| ES340821A1 (es) | 1968-09-16 |
| AT278805B (de) | 1970-02-10 |
| CH504458A (de) | 1971-03-15 |
| IL27143A (en) | 1972-01-27 |
| BE692749A (es) | 1967-07-17 |
| ES335760A1 (es) | 1968-03-16 |
| NL6700663A (es) | 1967-07-18 |
| US3444169A (en) | 1969-05-13 |
| DE1645954A1 (de) | 1970-07-16 |
| CH495371A (de) | 1970-08-31 |
| JPS5141639B1 (es) | 1976-11-11 |
| FR6274M (es) | 1968-08-26 |
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