ES345735A1 - Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas. - Google Patents

Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas.

Info

Publication number: ES345735A1
Authority: ES; Spain
Prior art keywords: pyrazino; hexahydro; quinoline; chloride; compound
Prior art date: 1966-10-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES345735A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

BASF Schweiz AG

Original Assignee

Ciba Geigy AG

Ciba AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-10-05

Filing date

1967-10-04

Publication date

1969-01-16

1966-10-05 Priority claimed from CH1436366A external-priority patent/CH493546A/de

1967-10-04 Application filed by Ciba Geigy AG, Ciba AG filed Critical Ciba Geigy AG

1969-01-16 Publication of ES345735A1 publication Critical patent/ES345735A1/es

Status Expired legal-status Critical Current

Links

FXNGILFJMJFFBM-UHFFFAOYSA-N 1h-pyrazino[1,2-a]quinoline Chemical class C1=CC=C2N3CC=NC=C3C=CC2=C1 FXNGILFJMJFFBM-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 10
239000000543 intermediate Substances 0.000 abstract 9
-1 p-methoxybenzoyl chloride 3 - (p - chlorobenzoyl) - 2,3,4,4a,5,6 - hexahydro- 1H pyrazino [1,2-a] quinoline Chemical compound 0.000 abstract 8
CHIINPDGHUONJZ-UHFFFAOYSA-N 2,3,4,4a,5,6-hexahydro-1h-pyrazino[1,2-a]quinoline Chemical class C1=CC=C2N3CCNCC3CCC2=C1 CHIINPDGHUONJZ-UHFFFAOYSA-N 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000004043 oxo group Chemical group O=* 0.000 abstract 2
SEGQXSVTXMMYNS-UHFFFAOYSA-N 1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl(furan-2-yl)methanone Chemical compound O1C(=CC=C1)C(=O)N1CC2N(C3=CC=CC=C3CC2)CC1 SEGQXSVTXMMYNS-UHFFFAOYSA-N 0.000 abstract 1
MTSSOURQBWGLJV-UHFFFAOYSA-N 1-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)-2-phenylethanone Chemical compound C1(=CC=CC=C1)CC(=O)N1CC2N(C3=CC=CC=C3CC2)CC1 MTSSOURQBWGLJV-UHFFFAOYSA-N 0.000 abstract 1
SAPAWHGNIMQFMR-UHFFFAOYSA-N 1-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethanone Chemical compound C1=CC=C2N3CCN(C(=O)C)CC3CCC2=C1 SAPAWHGNIMQFMR-UHFFFAOYSA-N 0.000 abstract 1
NTIJTEBBAZRBAW-UHFFFAOYSA-N 1-benzoyl-6-methyl-2h-quinoline-2-carbonitrile Chemical compound N#CC1C=CC2=CC(C)=CC=C2N1C(=O)C1=CC=CC=C1 NTIJTEBBAZRBAW-UHFFFAOYSA-N 0.000 abstract 1
OFTKFKYVSBNYEC-UHFFFAOYSA-N 2-furoyl chloride Chemical compound ClC(=O)C1=CC=CO1 OFTKFKYVSBNYEC-UHFFFAOYSA-N 0.000 abstract 1
VMZCDNSFRSVYKQ-UHFFFAOYSA-N 2-phenylacetyl chloride Chemical compound ClC(=O)CC1=CC=CC=C1 VMZCDNSFRSVYKQ-UHFFFAOYSA-N 0.000 abstract 1
XODLSVZKRPBFLU-UHFFFAOYSA-N N-[(6-methoxy-1,2,3,4-tetrahydroquinolin-2-yl)methyl]benzamide Chemical compound C(C1=CC=CC=C1)(=O)NCC1NC2=CC=C(C=C2CC1)OC XODLSVZKRPBFLU-UHFFFAOYSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000006264 debenzylation reaction Methods 0.000 abstract 1
JRVKTGJDUJGQEM-UHFFFAOYSA-N furan-2-yl-(8-methyl-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)methanone Chemical compound O1C(=CC=C1)C(=O)N1CC2N(C3=CC=C(C=C3CC2)C)CC1 JRVKTGJDUJGQEM-UHFFFAOYSA-N 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000012280 lithium aluminium hydride Substances 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940125723 sedative agent Drugs 0.000 abstract 1
239000000932 sedative agent Substances 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ES345735A 1966-10-05 1967-10-04 Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas. Expired ES345735A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH1436366A CH493546A (de)	1966-10-05	1966-10-05	Verfahren zur Herstellung neuer Pyrazino (1,2-a)-chinoline
CH156167		1967-02-02
CH1136267		1967-08-11

Publications (1)

Publication Number	Publication Date
ES345735A1 true ES345735A1 (es)	1969-01-16

Family

ID=27173075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES345735A Expired ES345735A1 (es)	1966-10-05	1967-10-04	Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas.

Country Status (7)

Country	Link
BE (1)	BE704690A (fr)
DE (1)	DE1670473A1 (fr)
ES (1)	ES345735A1 (fr)
FR (3)	FR1549373A (fr)
GB (1)	GB1143039A (fr)
GR (1)	GR36369B (fr)
NL (1)	NL6713503A (fr)

1967
- 1967-09-27 DE DE19671670473 patent/DE1670473A1/de active Pending
- 1967-10-03 FR FR1549373D patent/FR1549373A/fr not_active Expired
- 1967-10-03 GB GB45003/67A patent/GB1143039A/en not_active Expired
- 1967-10-04 BE BE704690D patent/BE704690A/xx unknown
- 1967-10-04 GR GR670136369A patent/GR36369B/el unknown
- 1967-10-04 NL NL6713503A patent/NL6713503A/xx unknown
- 1967-10-04 ES ES345735A patent/ES345735A1/es not_active Expired
- 1967-12-29 FR FR134278A patent/FR7108M/fr not_active Expired
- 1967-12-29 FR FR134279A patent/FR7109M/fr not_active Expired

Also Published As

Publication number	Publication date
DE1670473A1 (de)	1971-02-11
GR36369B (el)	1969-02-04
BE704690A (fr)	1968-04-04
FR7109M (fr)	1969-07-15
GB1143039A (en)	1969-02-19
FR7108M (fr)	1969-07-15
NL6713503A (fr)	1968-04-08
FR1549373A (fr)	1968-12-13

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