ES346793A1 - Un procedimiento para la preparacion de penicilinas. - Google Patents
Un procedimiento para la preparacion de penicilinas.Info
- Publication number
- ES346793A1 ES346793A1 ES346793A ES346793A ES346793A1 ES 346793 A1 ES346793 A1 ES 346793A1 ES 346793 A ES346793 A ES 346793A ES 346793 A ES346793 A ES 346793A ES 346793 A1 ES346793 A1 ES 346793A1
- Authority
- ES
- Spain
- Prior art keywords
- mono
- phenyl
- malonate
- phenylmalonate
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 6
- 150000002960 penicillins Chemical class 0.000 title abstract 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- WWYDYZMNFQIYPT-UHFFFAOYSA-N ru78191 Chemical class OC(=O)C(C(O)=O)C1=CC=CC=C1 WWYDYZMNFQIYPT-UHFFFAOYSA-N 0.000 abstract 4
- -1 aralkoxy Chemical group 0.000 abstract 3
- 229940049954 penicillin Drugs 0.000 abstract 3
- CVHLBFOTTUXOJT-UHFFFAOYSA-N 1-O-(2-phenoxyethyl) 3-O-phenyl propanedioate Chemical compound C(CC(=O)OC1=CC=CC=C1)(=O)OCCOC1=CC=CC=C1 CVHLBFOTTUXOJT-UHFFFAOYSA-N 0.000 abstract 2
- XYLZICPDVXMHLD-UHFFFAOYSA-N 1-O-ethyl 3-O-ethylsulfonyl 2-phenylpropanedioate Chemical compound C1(=CC=CC=C1)C(C(=O)OS(=O)(=O)CC)C(=O)OCC XYLZICPDVXMHLD-UHFFFAOYSA-N 0.000 abstract 2
- OXLGUJHNMFWFQI-UHFFFAOYSA-N 3-(2-ethylthiophen-3-yl)oxy-3-oxopropanoic acid Chemical compound CCC1=C(C=CS1)OC(=O)CC(=O)O OXLGUJHNMFWFQI-UHFFFAOYSA-N 0.000 abstract 2
- IBMRDGFOBCQXKY-UHFFFAOYSA-N 3-O-(4-chlorophenyl) 1-O-phenyl propanedioate Chemical compound ClC1=CC=C(OC(=O)CC(=O)OC2=CC=CC=C2)C=C1 IBMRDGFOBCQXKY-UHFFFAOYSA-N 0.000 abstract 2
- ILCZVFZOSDGLMA-UHFFFAOYSA-N 3-O-(4-methoxyphenyl) 1-O-phenyl propanedioate Chemical compound COC1=CC=C(OC(=O)CC(=O)OC2=CC=CC=C2)C=C1 ILCZVFZOSDGLMA-UHFFFAOYSA-N 0.000 abstract 2
- ASAVFZBEONGLCM-UHFFFAOYSA-N 3-[4-(2,6-dimethoxyphenyl)phenoxy]-3-oxopropanoic acid Chemical compound COC1=C(C(=CC=C1)OC)C2=CC=C(C=C2)OC(=O)CC(=O)O ASAVFZBEONGLCM-UHFFFAOYSA-N 0.000 abstract 2
- QPVAVQYXWABJQO-UHFFFAOYSA-N 3-naphthalen-2-yloxy-3-oxo-2-phenylpropanoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=O)C(C(=O)O)C1=CC=CC=C1 QPVAVQYXWABJQO-UHFFFAOYSA-N 0.000 abstract 2
- AGJYKOXUBOLFSW-UHFFFAOYSA-N 3-oxo-3-(2-phenylthiophen-3-yl)oxypropanoic acid Chemical compound C1=CC=C(C=C1)C2=C(C=CS2)OC(=O)CC(=O)O AGJYKOXUBOLFSW-UHFFFAOYSA-N 0.000 abstract 2
- YBEBCWKYTDYYOE-UHFFFAOYSA-N C(CC(=O)OC1=CC=CC=C1)(=O)OCC(CC)[N+](=O)[O-] Chemical compound C(CC(=O)OC1=CC=CC=C1)(=O)OCC(CC)[N+](=O)[O-] YBEBCWKYTDYYOE-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 235000019371 penicillin G benzathine Nutrition 0.000 abstract 2
- 229940056360 penicillin g Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- KMNMQDSIICMJOJ-UHFFFAOYSA-N 2-[4-(2-methylphenyl)phenyl]propanedioic acid Chemical compound C1(=C(C=CC=C1)C1=CC=C(C=C1)C(C(=O)O)C(=O)O)C KMNMQDSIICMJOJ-UHFFFAOYSA-N 0.000 abstract 1
- DKDMTYICFNTROW-UHFFFAOYSA-N 3-oxo-3-(3-phenylthiophen-2-yl)oxypropanoic acid Chemical compound C1=CC=C(C=C1)C2=C(SC=C2)OC(=O)CC(=O)O DKDMTYICFNTROW-UHFFFAOYSA-N 0.000 abstract 1
- IDJNJFYWPMDFNB-UHFFFAOYSA-N 3-oxo-3-phenoxy-2-phenylpropanoic acid Chemical compound C=1C=CC=CC=1C(C(=O)O)C(=O)OC1=CC=CC=C1 IDJNJFYWPMDFNB-UHFFFAOYSA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4969766A GB1133886A (en) | 1966-11-05 | 1966-11-05 | Penicillins |
| GB407967 | 1967-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES346793A1 true ES346793A1 (es) | 1969-02-16 |
Family
ID=26238849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES346793A Expired ES346793A1 (es) | 1966-11-05 | 1967-11-04 | Un procedimiento para la preparacion de penicilinas. |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT281284B (fr) |
| BE (1) | BE706051A (fr) |
| CH (1) | CH505853A (fr) |
| DK (1) | DK132085C (fr) |
| ES (1) | ES346793A1 (fr) |
| FI (1) | FI50426C (fr) |
| FR (1) | FR6819M (fr) |
| GB (1) | GB1133886A (fr) |
| NL (1) | NL153203B (fr) |
| NO (1) | NO131135C (fr) |
-
1966
- 1966-11-05 GB GB4969766A patent/GB1133886A/en not_active Expired
-
1967
- 1967-10-27 FI FI289867A patent/FI50426C/fi active
- 1967-10-30 NL NL676714747A patent/NL153203B/xx not_active IP Right Cessation
- 1967-10-30 NO NO17032267A patent/NO131135C/no unknown
- 1967-10-31 AT AT983067A patent/AT281284B/de not_active IP Right Cessation
- 1967-11-03 FR FR126847A patent/FR6819M/fr not_active Expired
- 1967-11-03 DK DK548267A patent/DK132085C/da active
- 1967-11-03 BE BE706051D patent/BE706051A/xx not_active IP Right Cessation
- 1967-11-04 ES ES346793A patent/ES346793A1/es not_active Expired
- 1967-11-06 CH CH1548867A patent/CH505853A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE706051A (fr) | 1968-05-03 |
| FI50426C (fi) | 1976-03-10 |
| DK132085B (da) | 1975-10-20 |
| CH505853A (de) | 1971-04-15 |
| GB1133886A (en) | 1968-11-20 |
| FR6819M (fr) | 1969-03-24 |
| NL6714747A (fr) | 1968-05-06 |
| DE1670284B2 (de) | 1976-02-26 |
| DE1670284A1 (de) | 1971-01-28 |
| NL153203B (nl) | 1977-05-16 |
| FI50426B (fr) | 1975-12-01 |
| NO131135C (fr) | 1975-04-09 |
| NO131135B (fr) | 1974-12-30 |
| DK132085C (da) | 1976-03-15 |
| AT281284B (de) | 1970-05-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES480850A1 (es) | Procedimiento para preparar hidantoinas. | |
| GB1351501A (en) | Adenosine derivatives and the production thereof | |
| GB1229082A (fr) | ||
| GB1336318A (en) | Derivatives of 7-aminocephalosporanic acid | |
| GB1318510A (en) | Thiono-phosphoric phosphonic acid esters a process for their preparation and their use as insecticides and acaricides | |
| GB1049960A (en) | Phosphorus-containing esters | |
| ES346793A1 (es) | Un procedimiento para la preparacion de penicilinas. | |
| GB1426869A (en) | Penicillins | |
| FR2329279A1 (fr) | Penicillines | |
| GB1433312A (en) | Insecticidal acaricidal and nematicidal phosphorus-containing pyrazoline derivatives | |
| GB1290841A (fr) | ||
| GB894460A (en) | Improvements in or relating to penicillins | |
| GB1337506A (en) | Oxobenzofuran carboxamide anti-inflammatory agents | |
| GB1391354A (en) | O-pyrazolopyrimidine-thiono-phosphoric-phosphonic or phosphinic- acid esters or ester-amides process for their production and their use as insecticides or acaricides | |
| ES8505934A1 (es) | Un metodo para preparar acidos diazin-etenilfenil-oxamicos | |
| GB1116775A (en) | ªß-hydroxy-acrylic acid derivatives and process for their manufacture | |
| SE8306298L (sv) | 7beta-isotiazolyltioacetamido-7alfa-metoxicefalosporansyraderivat | |
| GB1271054A (en) | Isoindoline and benzoisothiazoline derivatives, their preparation and pharmaceutical compositions containing them | |
| GB1424562A (en) | Phosphoramidothioates and their use as nematocides | |
| GB1434645A (en) | Tetrazole coumarin derivatives | |
| GB1368053A (en) | 3,4-dihydro-4-oxo-quinazolino/thiono/-phosphoric/phosphonic/-acid esters and esteramides process for their production and their use as insecticides or acaricides | |
| GB1410852A (en) | Substituted 4-biphenylyl-butenoic acids esters and amides and pharmaceutical compositions containing them | |
| ES357983A1 (es) | Un procedimiento para la preparacion de nuevos compuestos de 2,4-diamino-6-(acilamino sustituido) quinazolina. | |
| GB1224619A (en) | DERIVATIVES OF alpha-AMINOPENICILLINS | |
| ES403453A1 (es) | Un procedimiento para la preparacion de penicilinas. |