ES8505934A1 - Un metodo para preparar acidos diazin-etenilfenil-oxamicos - Google Patents

Un metodo para preparar acidos diazin-etenilfenil-oxamicos

Info

Publication number
ES8505934A1
ES8505934A1 ES535572A ES535572A ES8505934A1 ES 8505934 A1 ES8505934 A1 ES 8505934A1 ES 535572 A ES535572 A ES 535572A ES 535572 A ES535572 A ES 535572A ES 8505934 A1 ES8505934 A1 ES 8505934A1
Authority
ES
Spain
Prior art keywords
diazin
ethenylphenyl
formula
oxalate
oxamic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES535572A
Other languages
English (en)
Other versions
ES535572A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Corp
Original Assignee
Boehringer Ingelheim Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Corp filed Critical Boehringer Ingelheim Corp
Publication of ES8505934A1 publication Critical patent/ES8505934A1/es
Publication of ES535572A0 publication Critical patent/ES535572A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16—Halogen atoms; Nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

METODO PARA PREPARAR ACIDOS DIAZIN-ETENILFENIL-OXAMICOS.CONSISTE EN HACER REACCIONAR UNA 2-(AMINOFENIL)ETENIL DIAZINA DE FORMULA (II) CON UN HALURO DE OXALATO COMO CLORURO DE OXALATO O CON UN OXALATO DE DIALQUILO, EN PRESENCIA DE UNA BASE ORGANICA COMO PIRIDINA O TRIETILAMINA, EN LIQUIDOS INERTES COMO BENCENO, TOLVENO, XILENO Y OTROS Y ENFRIANDO LA MEZCLA DEREACCION, PARA OBTENER ACIDOS DIAZIN-ETENIL-FENIL-OXAMICOS DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES Y NO TOXICAS. SIENDO; R1, H O ALQUILO DE C 1 A 4; R2, H, METILO HIDROXILO Y OTROS; A UN RADICAL DE FORMULA (III) (IV) O (V); R3, H, METILO, ALCOXILO DE C 1 A 4 Y OTROS Y R4, H, AMINO, ALCOXILO DE C 1 A 4 Y OTROS.SE UTILIZAN PARA EL TRATAMIENTO DE ENFERMEDADES INMUNOLOGICAS, INFLAMATORIAS Y ALERGICAS.
ES535572A 1983-09-01 1984-08-31 Un metodo para preparar acidos diazin-etenilfenil-oxamicos Granted ES535572A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52852283A 1983-09-01 1983-09-01

Publications (2)

Publication Number Publication Date
ES8505934A1 true ES8505934A1 (es) 1985-06-16
ES535572A0 ES535572A0 (es) 1985-06-16

Family

ID=24106021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES535572A Granted ES535572A0 (es) 1983-09-01 1984-08-31 Un metodo para preparar acidos diazin-etenilfenil-oxamicos

Country Status (22)

Country Link
EP (1) EP0137979B1 (es)
JP (1) JPS60142968A (es)
KR (1) KR900001217B1 (es)
AT (1) ATE38224T1 (es)
AU (1) AU569541B2 (es)
CA (1) CA1219873A (es)
CS (1) CS241100B2 (es)
DD (1) DD227964A5 (es)
DE (1) DE3474817D1 (es)
DK (1) DK158725C (es)
ES (1) ES535572A0 (es)
FI (1) FI84477C (es)
GR (1) GR80245B (es)
HU (1) HU192576B (es)
IE (1) IE59035B1 (es)
IL (1) IL72833A (es)
NO (1) NO843477L (es)
NZ (1) NZ209405A (es)
PH (1) PH22753A (es)
PT (1) PT79163B (es)
SU (1) SU1342410A3 (es)
ZA (1) ZA846826B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62145049A (ja) * 1985-12-18 1987-06-29 Mitsubishi Chem Ind Ltd アミノスチリル化合物及びそれを有効成分とするロイコトリエンきつ抗剤
WO1992000963A1 (fr) * 1990-07-12 1992-01-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de styryle et leur utilisation comme medicaments
JP2832923B2 (ja) * 1990-07-13 1998-12-09 吉富製薬株式会社 スチリル化合物およびその医薬用途
WO1999035140A1 (en) * 1998-01-12 1999-07-15 Novartis Ag PYRIDINYLPYRIMIDINE AMINES AS IMMUNOGLOBULINE E (IgE) SYNTHESIS INHIBITORS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1259685A (en) * 1969-04-03 1972-01-12 Soc D Etudes Prod Chimique Amino-pyrimidine derivatives
US3993679A (en) * 1972-12-20 1976-11-23 The Upjohn Company Cyano phenylene dioxamic molecules
US4054666A (en) * 1973-03-23 1977-10-18 American Home Products Corporation Compositions and methods of treating immediate hypersensitivity reactions with thiazolyl oxamic acid derivatives
US3953468A (en) * 1974-03-15 1976-04-27 The Upjohn Company 3-Cyano thiophen-2-yl oxamic acid and derivatives
CA1066714A (en) * 1974-06-10 1979-11-20 John B. Wright Pharmaceutical n-phenyloxamic acid derivatives
DE2828091A1 (de) * 1978-06-27 1980-01-10 Boehringer Sohn Ingelheim 4-substituierte thiazoloxamsaeuren sowie ihre salze und ester
JPS5761028A (en) * 1980-09-30 1982-04-13 Sanyo Chem Ind Ltd Formation of heat-insulating primer layer and heat-insulating structure

Also Published As

Publication number Publication date
FI843417A7 (fi) 1985-03-02
DD227964A5 (de) 1985-10-02
IL72833A (en) 1987-09-16
IL72833A0 (en) 1984-11-30
EP0137979A1 (en) 1985-04-24
DK418484A (da) 1985-03-02
FI84477B (fi) 1991-08-30
EP0137979B1 (en) 1988-10-26
PT79163B (en) 1986-11-18
KR900001217B1 (ko) 1990-02-28
FI843417A0 (fi) 1984-08-30
NO843477L (no) 1985-03-04
CS241100B2 (en) 1986-03-13
NZ209405A (en) 1987-05-29
DE3474817D1 (en) 1988-12-01
SU1342410A3 (ru) 1987-09-30
DK158725B (da) 1990-07-09
IE59035B1 (en) 1993-12-15
GR80245B (en) 1985-01-03
HUT37129A (en) 1985-11-28
DK418484D0 (da) 1984-08-31
ES535572A0 (es) 1985-06-16
HU192576B (en) 1987-06-29
ATE38224T1 (de) 1988-11-15
PH22753A (en) 1988-11-28
DK158725C (da) 1990-12-10
IE842237L (en) 1985-03-01
ZA846826B (en) 1986-04-30
KR850002258A (ko) 1985-05-10
FI84477C (fi) 1991-12-10
PT79163A (en) 1984-09-01
JPS60142968A (ja) 1985-07-29
CA1219873A (en) 1987-03-31
AU569541B2 (en) 1988-02-04
CS654584A2 (en) 1985-07-16
AU3260084A (en) 1985-03-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110