ES364632A1 - Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. - Google Patents
Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina.Info
- Publication number
- ES364632A1 ES364632A1 ES364632A ES364632A ES364632A1 ES 364632 A1 ES364632 A1 ES 364632A1 ES 364632 A ES364632 A ES 364632A ES 364632 A ES364632 A ES 364632A ES 364632 A1 ES364632 A1 ES 364632A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- acetyl
- chloro
- benzyl
- formyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Dibenzazepine acetic acid derivatives Chemical class 0.000 title abstract 14
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 3
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 230000003301 hydrolyzing effect Effects 0.000 abstract 3
- 125000006083 1-bromoethyl group Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- ILROLYQPRYHHFG-UHFFFAOYSA-N 1-$l^{1}-oxidanylprop-2-en-1-one Chemical group [O]C(=O)C=C ILROLYQPRYHHFG-UHFFFAOYSA-N 0.000 abstract 1
- QBSUAHGUFKVVTM-UHFFFAOYSA-N 1-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)ethanone Chemical class C1CC2=CC=CC=C2N(C(=O)C)C2=CC=CC=C21 QBSUAHGUFKVVTM-UHFFFAOYSA-N 0.000 abstract 1
- MOMFXATYAINJML-UHFFFAOYSA-N 2-Acetylthiazole Chemical group CC(=O)C1=NC=CS1 MOMFXATYAINJML-UHFFFAOYSA-N 0.000 abstract 1
- LCGTWRLJTMHIQZ-UHFFFAOYSA-N 5H-dibenzo[b,f]azepine Chemical class C1=CC2=CC=CC=C2NC2=CC=CC=C21 LCGTWRLJTMHIQZ-UHFFFAOYSA-N 0.000 abstract 1
- ZSMRRZONCYIFNB-UHFFFAOYSA-N 6,11-dihydro-5h-benzo[b][1]benzazepine Chemical class C1CC2=CC=CC=C2NC2=CC=CC=C12 ZSMRRZONCYIFNB-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000012047 saturated solution Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000037072 sun protection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M3/00—Investigating fluid-tightness of structures
- G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH305568A CH501635A (de) | 1968-02-29 | 1968-02-29 | Verfahren zur Herstellung von neuen Derivaten des 5H-Dibenz(b,f)azepins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES364632A1 true ES364632A1 (es) | 1971-02-01 |
Family
ID=4247593
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES364632A Expired ES364632A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
| ES364634A Expired ES364634A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
| ES364635A Expired ES364635A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f). |
| ES364637A Expired ES364637A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
| ES364633A Expired ES364633A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES364634A Expired ES364634A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
| ES364635A Expired ES364635A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f). |
| ES364637A Expired ES364637A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
| ES364633A Expired ES364633A1 (es) | 1968-02-29 | 1969-02-28 | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f) azepina. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3624075A (es) |
| JP (3) | JPS4927876B1 (es) |
| AT (5) | AT289815B (es) |
| BE (1) | BE729209A (es) |
| BR (1) | BR6906750D0 (es) |
| CH (5) | CH501635A (es) |
| DE (2) | DE1965988A1 (es) |
| DK (1) | DK122725B (es) |
| ES (5) | ES364632A1 (es) |
| FR (1) | FR2002897A1 (es) |
| GB (1) | GB1259648A (es) |
| IL (1) | IL31715A (es) |
| NL (1) | NL6902779A (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230703A (en) * | 1977-04-01 | 1980-10-28 | Teikoku Hormone Mfg. Co., Ltd. | 11-Oxodibenz(b,e)azepines |
| US6468996B1 (en) * | 1998-10-21 | 2002-10-22 | Novo Nordisk A/S | Substituted hetero-polycyclic compounds as PPARα and PPARγ activators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH414643A (de) * | 1962-12-04 | 1966-06-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Azepinderivaten |
-
1968
- 1968-02-29 CH CH305568A patent/CH501635A/de not_active IP Right Cessation
- 1968-02-29 CH CH1281570A patent/CH501637A/de not_active IP Right Cessation
- 1968-02-29 CH CH1281670A patent/CH501638A/de not_active IP Right Cessation
- 1968-02-29 CH CH1281770A patent/CH501639A/de not_active IP Right Cessation
- 1968-02-29 CH CH1281870A patent/CH501640A/de not_active IP Right Cessation
-
1969
- 1969-02-21 DK DK98269AA patent/DK122725B/da unknown
- 1969-02-21 NL NL6902779A patent/NL6902779A/xx unknown
- 1969-02-24 US US801801A patent/US3624075A/en not_active Expired - Lifetime
- 1969-02-27 FR FR6905170A patent/FR2002897A1/fr not_active Withdrawn
- 1969-02-28 BE BE729209D patent/BE729209A/xx unknown
- 1969-02-28 ES ES364632A patent/ES364632A1/es not_active Expired
- 1969-02-28 ES ES364634A patent/ES364634A1/es not_active Expired
- 1969-02-28 AT AT201670A patent/AT289815B/de not_active IP Right Cessation
- 1969-02-28 DE DE19691965988 patent/DE1965988A1/de active Pending
- 1969-02-28 AT AT203869A patent/AT286994B/de not_active IP Right Cessation
- 1969-02-28 IL IL31715A patent/IL31715A/en unknown
- 1969-02-28 AT AT201770A patent/AT286997B/de not_active IP Right Cessation
- 1969-02-28 ES ES364635A patent/ES364635A1/es not_active Expired
- 1969-02-28 ES ES364637A patent/ES364637A1/es not_active Expired
- 1969-02-28 BR BR206750/69A patent/BR6906750D0/pt unknown
- 1969-02-28 AT AT02014/70A patent/AT286996B/de not_active IP Right Cessation
- 1969-02-28 AT AT201570A patent/AT287729B/de not_active IP Right Cessation
- 1969-02-28 GB GB1259648D patent/GB1259648A/en not_active Expired
- 1969-02-28 ES ES364633A patent/ES364633A1/es not_active Expired
- 1969-02-28 DE DE19691910291 patent/DE1910291A1/de active Pending
- 1969-02-28 JP JP44014996A patent/JPS4927876B1/ja active Pending
-
1971
- 1971-07-02 JP JP46048716A patent/JPS4929196B1/ja active Pending
- 1971-07-02 JP JP46048717A patent/JPS4929197B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL31715A0 (en) | 1969-04-30 |
| JPS4929196B1 (es) | 1974-08-01 |
| BE729209A (es) | 1969-08-28 |
| CH501638A (de) | 1971-01-15 |
| JPS4927876B1 (es) | 1974-07-22 |
| AT289815B (de) | 1971-05-10 |
| IL31715A (en) | 1972-01-27 |
| CH501635A (de) | 1971-01-15 |
| AT287729B (de) | 1971-02-10 |
| CH501637A (de) | 1971-01-15 |
| AT286996B (de) | 1971-01-11 |
| AT286994B (de) | 1971-01-11 |
| AT286997B (de) | 1971-01-11 |
| ES364634A1 (es) | 1971-02-01 |
| ES364633A1 (es) | 1971-02-01 |
| CH501640A (de) | 1971-01-15 |
| CH501639A (de) | 1971-01-15 |
| FR2002897A1 (es) | 1969-10-31 |
| BR6906750D0 (pt) | 1973-04-19 |
| DK122725B (da) | 1972-04-04 |
| US3624075A (en) | 1971-11-30 |
| NL6902779A (es) | 1969-09-02 |
| JPS4929197B1 (es) | 1974-08-01 |
| DE1910291A1 (de) | 1969-11-06 |
| ES364637A1 (es) | 1971-02-01 |
| GB1259648A (es) | 1972-01-05 |
| DE1965988A1 (de) | 1970-11-19 |
| ES364635A1 (es) | 1971-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4193926A (en) | 4-(Polyalkoxy phenyl)-2-pyrrolidones | |
| US4006180A (en) | [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids | |
| Acheson et al. | 513. Addition reactions of heterocyclic compounds. Part XVIII. The structures and reactions of adducts from pyridines, dimethyl acetylenedicarboxylate, and carbon dioxide at low temperatures | |
| ES364635A1 (es) | Procedimiento para la preparacion de nuevos derivados de 5h-dibenz (b,f). | |
| US3966966A (en) | Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids | |
| US3976681A (en) | [1,3-Dioxo-2-substituted and 2,2-disubstituted- indanyloxy (or thio] alkanoic acids | |
| US3631177A (en) | 3-phenacyl-2-oxoindolines | |
| US3803169A (en) | Cycloalkanoyl-substituted pyrroles | |
| US3833594A (en) | Amino derivatives of pyrazolopyridine carboxylic acids and esters | |
| GB1251696A (es) | ||
| GB1496491A (en) | Dihydroergopeptine derivatives | |
| US3629271A (en) | Pyrazolopyridine carboxylic acid compounds and derivatives | |
| US3686210A (en) | 2-acylamido-3-aryl-3h-indol-3-ol esters and related compounds | |
| ES382023A1 (es) | Procedimiento para preparar compuestos de alfa - carboxia- rilmetil penicilinas. | |
| US4212806A (en) | Aminopyrrole derivatives | |
| US4122091A (en) | Cyclopenta[B]thiophene derivatives | |
| GB1512537A (en) | 2-(2'-aryl-6'-chromonyl) propionic acids and analgesic and anti-inflammatory derivatives thereof | |
| US4198502A (en) | Aminopyrrole derivatives | |
| US4156000A (en) | Cyclopenta[b]thiophene derivatives | |
| US3426030A (en) | 4-tetrahydropyridylacrylic acid derivatives | |
| GB1389461A (en) | Pyridine-acetic acid derivatives | |
| GB1139164A (en) | New heterocyclic acetic acid compounds and methods for their production | |
| US3821248A (en) | Bis-(p-chlorphenoxy)acetic acid esters | |
| GB1126860A (en) | Novel 4-substituted-7- and 8-chloroquinolines and a process for the preparation thereof | |
| US4211709A (en) | Aminopyrrole derivatives |