ES367451A1 - Procedure for preparing i-glicosil-5-azacitosinas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing i-glicosil-5-azacitosinas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES367451A1 ES367451A1 ES367451A ES367451A ES367451A1 ES 367451 A1 ES367451 A1 ES 367451A1 ES 367451 A ES367451 A ES 367451A ES 367451 A ES367451 A ES 367451A ES 367451 A1 ES367451 A1 ES 367451A1
- Authority
- ES
- Spain
- Prior art keywords
- glicosil
- azacitosinas
- translation
- preparing
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- MFEFTTYGMZOIKO-UHFFFAOYSA-N 5-azacytosine Chemical compound NC1=NC=NC(=O)N1 MFEFTTYGMZOIKO-UHFFFAOYSA-N 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 238000005915 ammonolysis reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Gripping On Spindles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1-Glycosyl.5.azacytosines of the general formula wherein R is a glycosyl residue, R2 is a hydrogen atom or an alkyl group and R3 and R4 are each a hydrogen atom, an alkyl group or an aralky] group, are prepared by reaction of a per-acylglycosyl isocyanate of the general formula R5-N=C=O, wherein R5 is a per-acylglycosyl residue, with an acylguanidine of the general formula and subjection of the resulting l-(per-acylglycosyl)-5.azacytosine of the general formula to alcoholysis or ammonolysis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS770868 | 1968-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES367451A1 true ES367451A1 (en) | 1971-04-01 |
Family
ID=5426669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES367451A Expired ES367451A1 (en) | 1968-11-12 | 1969-05-20 | Procedure for preparing i-glicosil-5-azacitosinas. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT292205B (en) |
| BE (1) | BE732796A (en) |
| CH (1) | CH507969A (en) |
| DE (1) | DE1935027A1 (en) |
| DK (1) | DK128008B (en) |
| ES (1) | ES367451A1 (en) |
| FR (1) | FR2023018A1 (en) |
| GB (1) | GB1227692A (en) |
| IT (1) | IT1033029B (en) |
| NL (1) | NL6907961A (en) |
| NO (1) | NO126626B (en) |
| SE (1) | SE350048B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2012888C3 (en) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Process for the preparation of 5-azapyrimidine nucleosides |
| US6943249B2 (en) | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US7038038B2 (en) | 2003-03-17 | 2006-05-02 | Pharmion Corporation | Synthesis of 5-azacytidine |
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| HUE055911T2 (en) | 2008-05-15 | 2021-12-28 | Celgene Corp | Oral compositions containing cytidine analogs and methods for their use |
| JP6289361B2 (en) | 2011-03-31 | 2018-03-07 | セルジーン インターナショナル サルル | Synthesis of 5-azacytidine |
-
1969
- 1969-04-24 CH CH624769A patent/CH507969A/en not_active IP Right Cessation
- 1969-05-06 NO NO185469A patent/NO126626B/no unknown
- 1969-05-08 AT AT440869A patent/AT292205B/en not_active IP Right Cessation
- 1969-05-08 GB GB1227692D patent/GB1227692A/en not_active Expired
- 1969-05-09 BE BE732796D patent/BE732796A/xx unknown
- 1969-05-13 SE SE681169A patent/SE350048B/xx unknown
- 1969-05-20 ES ES367451A patent/ES367451A1/en not_active Expired
- 1969-05-23 NL NL6907961A patent/NL6907961A/xx unknown
- 1969-05-30 DK DK292969A patent/DK128008B/en unknown
- 1969-06-20 FR FR6920666A patent/FR2023018A1/fr not_active Withdrawn
- 1969-07-04 IT IT1919969A patent/IT1033029B/en active
- 1969-07-10 DE DE19691935027 patent/DE1935027A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH507969A (en) | 1971-05-31 |
| IT1033029B (en) | 1979-07-10 |
| SE350048B (en) | 1972-10-16 |
| DE1935027A1 (en) | 1970-06-04 |
| BE732796A (en) | 1969-10-16 |
| FR2023018A1 (en) | 1970-08-07 |
| NO126626B (en) | 1973-03-05 |
| DK128008B (en) | 1974-02-18 |
| GB1227692A (en) | 1971-04-07 |
| NL6907961A (en) | 1970-05-14 |
| AT292205B (en) | 1971-08-25 |
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