ES368518A1 - Procedimiento de preparacion de derivados de esteroides. - Google Patents

Procedimiento de preparacion de derivados de esteroides.

Info

Publication number: ES368518A1
Authority: ES; Spain
Prior art keywords: preparation; methylacetamido; esters; relating; composition containing
Prior art date: 1968-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES368518A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

PHARMA CHEMIE

Original Assignee

PHARMA CHEMIE

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-06-10

Filing date

1969-06-07

Publication date

1971-05-01

1969-06-07 Application filed by PHARMA CHEMIE filed Critical PHARMA CHEMIE

1971-05-01 Publication of ES368518A1 publication Critical patent/ES368518A1/es

Status Expired legal-status Critical Current

Links

150000003431 steroids Chemical class 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
SUPOKHOQAKXOHJ-BYZMTCBYSA-N (8s,9s,10r,13r,14s,17s)-17-ethyl-10,13-dimethyl-2,3,6,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthrene Chemical compound C1CC2=CCCC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 SUPOKHOQAKXOHJ-BYZMTCBYSA-N 0.000 abstract 1
QQCBOIWDENXRLP-BYZMTCBYSA-N (8s,9s,10r,13r,14s,17s)-17-ethyl-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydro-3h-cyclopenta[a]phenanthrene Chemical class C1CC2=CCC=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](CC)[C@@]1(C)CC2 QQCBOIWDENXRLP-BYZMTCBYSA-N 0.000 abstract 1
WPHGIIWEXHFKHI-UHFFFAOYSA-N 4-[acetyl(methyl)amino]benzoic acid Chemical compound CC(=O)N(C)C1=CC=C(C(O)=O)C=C1 WPHGIIWEXHFKHI-UHFFFAOYSA-N 0.000 abstract 1
JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 abstract 1
FFBXWRKACVJWAA-UHFFFAOYSA-N CN(C(C)=O)C1=CC=C(C(=O)Cl)C=C1 Chemical compound CN(C(C)=O)C1=CC=C(C(=O)Cl)C=C1 FFBXWRKACVJWAA-UHFFFAOYSA-N 0.000 abstract 1
150000001263 acyl chlorides Chemical class 0.000 abstract 1
239000003470 adrenal cortex hormone Substances 0.000 abstract 1
230000002804 anti-anaphylactic effect Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000001741 anti-phlogistic effect Effects 0.000 abstract 1
229960002537 betamethasone Drugs 0.000 abstract 1
UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 abstract 1
239000000969 carrier Substances 0.000 abstract 1
RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 abstract 1
229960003957 dexamethasone Drugs 0.000 abstract 1
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960005205 prednisolone Drugs 0.000 abstract 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
229960004618 prednisone Drugs 0.000 abstract 1
XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
238000011200 topical administration Methods 0.000 abstract 1
229960005294 triamcinolone Drugs 0.000 abstract 1
GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ES368518A 1968-06-10 1969-06-07 Procedimiento de preparacion de derivados de esteroides. Expired ES368518A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR154433A FR7455M (fr)	1968-06-10	1968-06-10

Publications (1)

Publication Number	Publication Date
ES368518A1 true ES368518A1 (es)	1971-05-01

Family

ID=8650990

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES368518A Expired ES368518A1 (es)	1968-06-10	1969-06-07	Procedimiento de preparacion de derivados de esteroides.

Country Status (6)

Country	Link
BE (1)	BE733889A (fr)
CH (1)	CH510656A (fr)
DE (1)	DE1929264A1 (fr)
ES (1)	ES368518A1 (fr)
FR (1)	FR7455M (fr)
GB (1)	GB1223087A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4011317A (en) *	1975-08-22	1977-03-08	Rorer Italiana S.P.A.	Steroid derivatives

1968
- 1968-06-10 FR FR154433A patent/FR7455M/fr not_active Expired
1969
- 1969-05-30 BE BE733889D patent/BE733889A/xx unknown
- 1969-06-06 CH CH867969A patent/CH510656A/fr not_active IP Right Cessation
- 1969-06-06 GB GB28708/69A patent/GB1223087A/en not_active Expired
- 1969-06-07 ES ES368518A patent/ES368518A1/es not_active Expired
- 1969-06-10 DE DE19691929264 patent/DE1929264A1/de active Pending

Also Published As

Publication number	Publication date
FR7455M (fr)	1969-11-24
GB1223087A (en)	1971-02-24
DE1929264A1 (de)	1970-12-03
BE733889A (fr)	1969-11-03
CH510656A (fr)	1971-07-31

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