ES368785A1 - A PROCEDURE FOR THE PRODUCTION OF 2- (4-THIAZOLIL) BENZYMIDAZOLES. - Google Patents

A PROCEDURE FOR THE PRODUCTION OF 2- (4-THIAZOLIL) BENZYMIDAZOLES.

Info

Publication number
ES368785A1
ES368785A1 ES368785A ES368785A ES368785A1 ES 368785 A1 ES368785 A1 ES 368785A1 ES 368785 A ES368785 A ES 368785A ES 368785 A ES368785 A ES 368785A ES 368785 A1 ES368785 A1 ES 368785A1
Authority
ES
Spain
Prior art keywords
group
formula
see formula
procedure
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES368785A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES368785A1 publication Critical patent/ES368785A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A procedure for the production of 2- (4-thiazolyl) -benzimidazoles of the formula: **(See formula)** where R is selected from the group consisting of lower alkoxy, phenyl and para-fluorophenyl and the group (see formula) is located in position 5 (6), whose procedure consists of reacting a phenylenediamine of formula: **(See formula)** with a thiazole of formula: **(See formula)** where R is as described above, R1 is selected from the group consisting of hydrogen and hydroxymethyl and R2 is selected from the group consisting of -CHO, -CN, -COOH, -COOR3, -COX, -CONH2, an ortho-ester group and a group (see formula), where R3 is lower alkyl and X is halogen, with the proviso that when R is hydroxymethyl, R2 is -COOH, and recover the products obtained. (Machine-translation by Google Translate, not legally binding)
ES368785A 1968-06-28 1969-06-25 A PROCEDURE FOR THE PRODUCTION OF 2- (4-THIAZOLIL) BENZYMIDAZOLES. Expired ES368785A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA23905 1968-06-28

Publications (1)

Publication Number Publication Date
ES368785A1 true ES368785A1 (en) 1971-07-16

Family

ID=4084337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES368785A Expired ES368785A1 (en) 1968-06-28 1969-06-25 A PROCEDURE FOR THE PRODUCTION OF 2- (4-THIAZOLIL) BENZYMIDAZOLES.

Country Status (9)

Country Link
AT (1) AT291997B (en)
BR (1) BR6910208D0 (en)
CH (2) CH521991A (en)
CS (1) CS151520B2 (en)
ES (1) ES368785A1 (en)
FR (1) FR2014401A1 (en)
NL (1) NL6909069A (en)
PL (1) PL80115B1 (en)
SE (1) SE343867B (en)

Also Published As

Publication number Publication date
AT291997B (en) 1971-08-10
SE343867B (en) 1972-03-20
CH560221A5 (en) 1975-03-27
CH521991A (en) 1972-04-30
FR2014401A1 (en) 1970-04-17
PL80115B1 (en) 1975-08-30
CS151520B2 (en) 1973-10-19
BR6910208D0 (en) 1973-02-08
NL6909069A (en) 1969-12-30

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