ES373596A1 - A PROCEDURE FOR THE PREPARATION OF BENZODIAZEPINES. - Google Patents

A PROCEDURE FOR THE PREPARATION OF BENZODIAZEPINES.

Info

Publication number
ES373596A1
ES373596A1 ES373596A ES373596A ES373596A1 ES 373596 A1 ES373596 A1 ES 373596A1 ES 373596 A ES373596 A ES 373596A ES 373596 A ES373596 A ES 373596A ES 373596 A1 ES373596 A1 ES 373596A1
Authority
ES
Spain
Prior art keywords
formula
alkoxy
benzodiazepines
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES373596A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES373596A1 publication Critical patent/ES373596A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D497/00Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of the general formula (R, R 1 , R 2 = H, halogen, CF 3 , C 1-7 alkyl, alkoxy or alkylthio R 3 = H, CH 3 X = C 1-7 , alkoxy, C 2-8 acyloxy) are prepared by (a) treating a compound of the formula with BX (B = H, alkali metal) or (b)-when X = alkoxy-treating a compound of the formula with a strong base and an alkanol. They may be converted to compounds of the formula (R 4 = OH, R 5 = H or R 4+5 = additional C-N bond) by treatment with a complex metal hydride, optionally followed by dehydration.
ES373596A 1968-11-18 1969-11-17 A PROCEDURE FOR THE PREPARATION OF BENZODIAZEPINES. Expired ES373596A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77677568A 1968-11-18 1968-11-18

Publications (1)

Publication Number Publication Date
ES373596A1 true ES373596A1 (en) 1973-04-16

Family

ID=25108328

Family Applications (1)

Application Number Title Priority Date Filing Date
ES373596A Expired ES373596A1 (en) 1968-11-18 1969-11-17 A PROCEDURE FOR THE PREPARATION OF BENZODIAZEPINES.

Country Status (14)

Country Link
AT (1) AT294839B (en)
BE (1) BE741765A (en)
BR (1) BR6914223D0 (en)
CH (1) CH526557A (en)
DE (1) DE1957961A1 (en)
ES (1) ES373596A1 (en)
FI (1) FI50626C (en)
FR (1) FR2023553A1 (en)
GB (1) GB1233828A (en)
IL (1) IL33251A0 (en)
NL (1) NL6916954A (en)
NO (2) NO126625B (en)
SE (2) SE367198B (en)
YU (1) YU34206B (en)

Also Published As

Publication number Publication date
FI50626B (en) 1976-02-02
NO127349B (en) 1973-06-12
YU34206B (en) 1979-02-28
FR2023553A1 (en) 1970-08-21
GB1233828A (en) 1971-06-03
FI50626C (en) 1976-05-10
YU287869A (en) 1978-06-30
AT294839B (en) 1971-12-10
SE398748B (en) 1978-01-16
CH526557A (en) 1972-08-15
DE1957961A1 (en) 1970-06-18
SE367198B (en) 1974-05-20
IL33251A0 (en) 1969-12-31
NO126625B (en) 1973-03-05
BR6914223D0 (en) 1973-02-08
BE741765A (en) 1970-05-19
NL6916954A (en) 1970-05-20

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