ES384026A1 - Un procedimiento para la produccion de penicilinas hipo-a- lergenicas. - Google Patents

Un procedimiento para la produccion de penicilinas hipo-a- lergenicas.

Info

Publication number: ES384026A1
Authority: ES; Spain
Prior art keywords: penicillin; hypoallergenic; allergenic; hypo; alpha
Prior art date: 1968-02-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES384026A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

Astra AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-02-15

Filing date

1970-09-26

Publication date

1973-04-16

1968-12-03 Priority claimed from GB57373/68A external-priority patent/GB1261711A/en

1970-09-26 Application filed by Astra AB filed Critical Astra AB

1973-04-16 Publication of ES384026A1 publication Critical patent/ES384026A1/es

Status Expired legal-status Critical Current

Links

230000000774 hypoallergenic effect Effects 0.000 title abstract 10
229930182555 Penicillin Natural products 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
150000002960 penicillins Chemical class 0.000 title abstract 2
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 3
229940049954 penicillin Drugs 0.000 abstract 2
229940056360 penicillin g Drugs 0.000 abstract 2
NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
108010073038 Penicillin Amidase Proteins 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
125000000068 chlorophenyl group Chemical group 0.000 abstract 1
230000007515 enzymatic degradation Effects 0.000 abstract 1
235000019371 penicillin G benzathine Nutrition 0.000 abstract 1
229960004894 pheneticillin Drugs 0.000 abstract 1
ULBKMFLWMIGVOJ-CFXUUZMDSA-M propicillin potassium Chemical compound [K+].N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C([O-])=O)=O)C(=O)C(CC)OC1=CC=CC=C1 ULBKMFLWMIGVOJ-CFXUUZMDSA-M 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
- C12N9/84—Penicillin amidase (3.5.1.11)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Medicinal Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Handcart (AREA)

ES384026A 1968-02-15 1970-09-26 Un procedimiento para la produccion de penicilinas hipo-a- lergenicas. Expired ES384026A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB754468		1968-02-15
GB57373/68A GB1261711A (en)	1968-02-15	1968-12-03	Process for producing a penicillin acylose composition

Publications (1)

Publication Number	Publication Date
ES384026A1 true ES384026A1 (es)	1973-04-16

Family

ID=26241501

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
ES363592A Expired ES363592A1 (es)	1968-02-15	1969-02-13	Procedimiento para la fabricacion de una preparacion enzi- matica.
ES384026A Expired ES384026A1 (es)	1968-02-15	1970-09-26	Un procedimiento para la produccion de penicilinas hipo-a- lergenicas.
ES384025A Expired ES384025A1 (es)	1968-02-15	1970-09-26	Un procedimiento para la produccion de esteres de acido 6- aminopenicilanico.
ES70384027A Expired ES384027A1 (es)	1968-02-15	1970-12-26	Un procedimiento para la produccion de acido 6-aminopenici-lanico.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES363592A Expired ES363592A1 (es)	1968-02-15	1969-02-13	Procedimiento para la fabricacion de una preparacion enzi- matica.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES384025A Expired ES384025A1 (es)	1968-02-15	1970-09-26	Un procedimiento para la produccion de esteres de acido 6- aminopenicilanico.
ES70384027A Expired ES384027A1 (es)	1968-02-15	1970-12-26	Un procedimiento para la produccion de acido 6-aminopenici-lanico.

Country Status (17)

Country	Link
JP (2)	JPS4833386B1 (es)
AT (2)	AT300198B (es)
BE (1)	BE727506A (es)
CA (1)	CA941769A (es)
CH (2)	CH523320A (es)
CS (1)	CS155970B2 (es)
DE (4)	DE1966428C3 (es)
DK (1)	DK128421B (es)
ES (4)	ES363592A1 (es)
FI (1)	FI47109C (es)
FR (2)	FR2001977A1 (es)
IE (1)	IE32962B1 (es)
IT (1)	IT1061759B (es)
NL (1)	NL158547B (es)
NO (3)	NO131388C (es)
SE (3)	SE382990B (es)
SU (1)	SU404195A3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1357317A (en) *	1970-08-27	1974-06-19	Beecham Group Ltd	Enzymes
IL39158A (en) *	1971-04-28	1977-08-31	Snam Progetti	Enzymatic scission and synthesis of penicillins and cephalosporins
BE791748A (fr) *	1971-11-23	1973-05-22	Bayer Ag	Procede de production d'acide 6-aminopenicillanique par ruptureenzymatique de penicillines
JPS5420193A (en) *	1977-07-12	1979-02-15	Tanabe Seiyaku Co Ltd	Immobilized aminoacylase and its preparation
GB9718740D0 (en)	1997-09-05	1997-11-12	Advanced Phytonics Ltd	Improvements in or relating to the preparation of a compound
DE10123048A1 (de) *	2001-05-11	2002-11-21	Bermatingen Maschf	Messer für Kreiselmulchgeräte

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB877898A (en) *	1956-12-06	1961-09-20	Apv Co Ltd	A new or improved method of liberating enzymes
GB1118566A (en) *	1964-11-25	1968-07-03	Beecham Group Ltd	Production of 6-aminopenicillanic acid

1969
- 1969-01-24 BE BE727506D patent/BE727506A/xx unknown
- 1969-02-01 IT IT34651/69A patent/IT1061759B/it active
- 1969-02-04 CA CA041,889A patent/CA941769A/en not_active Expired
- 1969-02-06 AT AT100971A patent/AT300198B/de not_active IP Right Cessation
- 1969-02-06 AT AT118469A patent/AT297218B/de not_active IP Right Cessation
- 1969-02-10 NL NL6902045.A patent/NL158547B/xx not_active IP Right Cessation
- 1969-02-11 SE SE7111628A patent/SE382990B/xx unknown
- 1969-02-11 SE SE01820/69A patent/SE352643B/xx unknown
- 1969-02-13 SU SU1309423A patent/SU404195A3/ru active
- 1969-02-13 ES ES363592A patent/ES363592A1/es not_active Expired
- 1969-02-14 DE DE1966428A patent/DE1966428C3/de not_active Expired
- 1969-02-14 NO NO610/69A patent/NO131388C/no unknown
- 1969-02-14 CH CH226769A patent/CH523320A/de not_active IP Right Cessation
- 1969-02-14 FR FR6903732A patent/FR2001977A1/fr active Granted
- 1969-02-14 CS CS176071*1A patent/CS155970B2/cs unknown
- 1969-02-14 IE IE199/69A patent/IE32962B1/xx unknown
- 1969-02-14 DE DE19691907365 patent/DE1907365A1/de active Pending
- 1969-02-14 DK DK80469AA patent/DK128421B/da unknown
- 1969-02-14 FI FI690482A patent/FI47109C/fi active
- 1969-02-14 DE DE1966427A patent/DE1966427C3/de not_active Expired
- 1969-02-14 DE DE19691933301 patent/DE1933301A1/de active Pending
- 1969-02-15 JP JP44010799A patent/JPS4833386B1/ja active Pending
- 1969-05-23 NO NO692139A patent/NO131387C/no unknown
1970
- 1970-09-26 ES ES384026A patent/ES384026A1/es not_active Expired
- 1970-09-26 ES ES384025A patent/ES384025A1/es not_active Expired
- 1970-12-16 FR FR7045429A patent/FR2081316B1/fr not_active Expired
- 1970-12-26 ES ES70384027A patent/ES384027A1/es not_active Expired
1971
- 1971-09-14 SE SE7111629A patent/SE400291B/xx unknown
1972
- 1972-02-14 CH CH79172A patent/CH538540A/de unknown
1973
- 1973-01-29 NO NO73361A patent/NO131386C/no unknown
1979
- 1979-03-13 JP JP2909779A patent/JPS5622278B1/ja active Pending

Also Published As

Publication number	Publication date
JPS5622278B1 (es)	1981-05-23
AT300198B (de)	1972-07-10
DE1966427C3 (de)	1980-03-13
IE32962B1 (en)	1974-02-06
IT1061759B (it)	1983-04-30
FR2081316A1 (es)	1971-12-03
ES384027A1 (es)	1973-06-01
CA941769A (en)	1974-02-12
CH538540A (de)	1973-08-15
CH523320A (de)	1972-05-31
IE32962L (en)	1969-08-15
NO131388B (es)	1975-02-10
BE727506A (es)	1969-07-01
NO131386B (es)	1975-02-10
DE1966428C3 (de)	1978-03-02
DE1907365A1 (de)	1969-09-11
SU404195A3 (es)	1973-10-26
DE1966427B2 (de)	1979-07-12
CS155970B2 (es)	1974-06-24
NL158547B (nl)	1978-11-15
JPS4833386B1 (es)	1973-10-13
FR2001977B1 (es)	1974-08-30
FI47109C (fi)	1973-09-10
FR2081316B1 (es)	1974-08-30
ES363592A1 (es)	1970-12-16
DE1966428A1 (de)	1972-09-14
FI47109B (es)	1973-05-31
SE352643B (es)	1973-01-08
SE400291B (sv)	1978-03-20
NO131386C (es)	1975-05-21
FR2001977A1 (en)	1969-10-03
DK128421B (da)	1974-04-29
DE1966428B2 (de)	1977-07-21
ES384025A1 (es)	1973-04-16
DE1966427A1 (de)	1972-08-24
DE1933301A1 (de)	1970-06-25
SE382990B (sv)	1976-02-23
NL6902045A (es)	1969-08-19
NO131388C (es)	1975-05-21
NO131387B (es)	1975-02-10
AT297218B (de)	1972-03-10
NO131387C (es)	1975-05-21

Publication	Publication Date	Title
ES384027A1 (es)	1973-06-01	Un procedimiento para la produccion de acido 6-aminopenici-lanico.
ES440046A1 (es)	1977-05-16	Un procedimiento para la preparacion del antibiotico xk-62- 2.
AT318146B (de)	1974-09-25	Verfahren zur Herstellung von reiner, kristalliner Penicillinacylase
ES385907A1 (es)	1974-01-01	Procedimiento de desdoblamiento para la produccion de acido6-aminopenicilanico.
ES414616A1 (es)	1976-01-16	Un metodo de producir acido alfa-amino-beta-hidroxibutanoi-co.
CA497540A (en)	1953-11-10	Method of preparing esters of .delta.3,5,7,9(11),22_ergostapentaene-3-ol
CA980764A (en)	1975-12-30	METHOD FOR THE PRODUCTION OF D(-)-.alpha.-AMINOBENZYPENICILLIN DIRECTLY FROM NATURAL PENICILLINS
ES400897A1 (es)	1975-02-01	Un procedimiento para la preparacion de alfa-amino-p-hidro-xibencilpenicilina o de un ester de grafito.
AU3403468A (en)	1969-08-28	Process forthe production of semisynthetic penicillins by enzymatic action
GR20493B (el)	1960-01-29	Μεθοδος παρασκευης πενικιλλινης.
CA910574A (en)	1972-09-26	Method of making formed thermosetting polydiene articles
CA860891A (en)	1971-01-12	Process for the production of artificial leather
AU250539B2 (en)	1960-10-27	Method forthe production of 6-amino-penicillanic acid
CA862102A (en)	1971-01-26	Method for the production of new penicillins
AU2219570A (en)	1972-05-18	Process forthe production of new heterocyclic carboxylic acids
CA533317A (en)	1956-11-20	Method of producing 1,4-dicyano-2-butene
AU257295B2 (en)	1963-05-02	Process forthe production of cycloserine
CA841328A (en)	1970-05-12	Process for the production of artificial leather
AU451047B2 (en)	1970-12-10	Method for production of l asparaginase
AU162379B2 (en)	1953-07-09	Method or process of shell molding
ES257220A1 (es)	1960-06-16	Procedimiento para la obtencion de acidos 6-aminopenicilanico
AU256660B2 (en)	1962-09-20	New penicillins and method for their production
CA489437A (en)	1953-01-06	Method for the production of titanium
CA489436A (en)	1953-01-06	Method for the production of titanium
CA489438A (en)	1953-01-06	Method for the production of titanium