ES385836A1 - Procedure for the preparation of 10 - piperazine -10,11 - dihidrodibenzo (b, f) thyrines. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 10 - piperazine -10,11 - dihidrodibenzo (b, f) thyrines. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES385836A1 ES385836A1 ES385836A ES385836A ES385836A1 ES 385836 A1 ES385836 A1 ES 385836A1 ES 385836 A ES385836 A ES 385836A ES 385836 A ES385836 A ES 385836A ES 385836 A1 ES385836 A1 ES 385836A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- formula
- group
- carbon atoms
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- -1 alkoxy radical Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for the preparation of 10-piperazino-10,11-dihydrodibenzo/b, f/neuroleptically active thiepins of the general formula I **(See formula)** where R1 means a hydrogen atom or a halogen atom, a trifluoromethyl group, an alcohol or alkoxy radical, an alcoholylthio group or an alkanesulfonyl group with 1 to 4 carbon atoms, a nitro or cyano group and R2 means an atom of hydrogen, an alcohol or hydroxyalkyl radical with 1 to 4 carbon atoms, an alkenyl or alkynyl radical with 2 to 4 carbon atoms, a cycloalkoxy radical with 3 to 8 carbon atoms, a benzyl radical, which is optionally substituted in the nucleus benzene with a halogen atom or an alcoholic radical, alkoxy, trifluoromethyl or with an alcoholylthio group, as well as its salts, characterized in that 10- [bis- (2-halogenoethyl) -amino] -10,11- is reacted dihydrodibenzo/b, f/thiepins of the general formula II **(See formula)** in which R1 means the same as in formula I and Hal means a chlorine or bromine atom, with amino compounds of formula III R2-NH2/III / wherein R2 means the same as in formula I, after which the basic products resulting from general formula I are transformed, optionally by neutralization with organic or inorganic acids, into the corresponding salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CS7751A CS149764B1 (en) | 1969-11-25 | 1969-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES385836A1 true ES385836A1 (en) | 1973-05-01 |
Family
ID=5427149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES385836A Expired ES385836A1 (en) | 1969-11-25 | 1970-11-24 | Procedure for the preparation of 10 - piperazine -10,11 - dihidrodibenzo (b, f) thyrines. (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT310170B (en) |
| BR (1) | BR7024157D0 (en) |
| CH (1) | CH544771A (en) |
| CS (1) | CS149764B1 (en) |
| ES (1) | ES385836A1 (en) |
| NL (1) | NL7017200A (en) |
| ZA (1) | ZA707985B (en) |
-
1969
- 1969-11-25 CS CS7751A patent/CS149764B1/cs unknown
-
1970
- 1970-11-24 AT AT10577/70A patent/AT310170B/en not_active IP Right Cessation
- 1970-11-24 CH CH1736970A patent/CH544771A/en not_active IP Right Cessation
- 1970-11-24 ES ES385836A patent/ES385836A1/en not_active Expired
- 1970-11-25 BR BR224157/70A patent/BR7024157D0/en unknown
- 1970-11-25 NL NL7017200A patent/NL7017200A/xx unknown
- 1970-11-25 ZA ZA707985A patent/ZA707985B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7017200A (en) | 1971-05-27 |
| BR7024157D0 (en) | 1973-03-07 |
| CH544771A (en) | 1974-01-15 |
| ZA707985B (en) | 1971-09-29 |
| AT310170B (en) | 1973-08-15 |
| CS149764B1 (en) | 1973-08-23 |
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