ES440030A1 - 2-aminoindane derivatives - Google Patents
2-aminoindane derivativesInfo
- Publication number
- ES440030A1 ES440030A1 ES440030A ES440030A ES440030A1 ES 440030 A1 ES440030 A1 ES 440030A1 ES 440030 A ES440030 A ES 440030A ES 440030 A ES440030 A ES 440030A ES 440030 A1 ES440030 A1 ES 440030A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- radical
- see formula
- see
- aminoindane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LMHHFZAXSANGGM-UHFFFAOYSA-N 2-aminoindane Chemical class C1=CC=C2CC(N)CC2=C1 LMHHFZAXSANGGM-UHFFFAOYSA-N 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
A procedure to prepare new 2-aminoindane derivatives of the general formula: **(See formula)** in which n is equal to 2, 3 or 4, with the group (CH2) n having a straight chain in which one or more hydrogen atoms may be replaced by a hydroxyl radical, R1 represents a lower alcohol or lower hydroxyalkyl radical than contains 1 to 4 carbon atoms or a lower alkenyl or lower alkynyl radical containing 2 or 3 carbon atoms, A is an unsubstituted phenyl radical or a phenyl radical substituted with at least one substituent at the ortho, meta and/positions or for as well as the acid addition salts of said derivatives of formula I, comprising, reacting an N-phenyl [or N- (2-pyridyl)] - 2-aminoindane of the formula **(See formula)** in which A has the meaning defined in the form of its sodium salt with a halogenated amine of the formula: **(See formula)** in which R1 and n have the defined meaning and Hal represents a halogen atom, preferably a chlorine or bromine atom, or in reacting a compound of formula: **(See formula)** with a primary amine of the formula **(See formula)** the compound of formula I obtained being transformed, if necessary, into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4315072 | 1972-09-18 | ||
| GB998873 | 1973-03-01 | ||
| GB998773*[A GB1405444A (en) | 1972-09-18 | 1973-03-01 | 2-aminoindane derivatives |
| GB1030373 | 1973-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES440030A1 true ES440030A1 (en) | 1977-02-16 |
Family
ID=27447738
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418827A Expired ES418827A1 (en) | 1972-09-18 | 1973-09-17 | 2-aminoindane derivatives |
| ES440030A Expired ES440030A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
| ES440029A Expired ES440029A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418827A Expired ES418827A1 (en) | 1972-09-18 | 1973-09-17 | 2-aminoindane derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES440029A Expired ES440029A1 (en) | 1972-09-18 | 1975-08-05 | 2-aminoindane derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5327263B2 (en) |
| AR (4) | AR206505A1 (en) |
| CA (1) | CA992547A (en) |
| CH (1) | CH585690A5 (en) |
| DD (2) | DD109802A5 (en) |
| ES (3) | ES418827A1 (en) |
| FR (1) | FR2199988B1 (en) |
| GB (1) | GB1405444A (en) |
| HU (1) | HU168018B (en) |
| IL (1) | IL43218A (en) |
| LU (1) | LU68426A1 (en) |
| MX (1) | MX3233E (en) |
| NL (1) | NL152246B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4975461A (en) * | 1986-06-19 | 1990-12-04 | E. R. Squibb & Sons, Inc. | P-aminophenols, derivatives thereof and method of use |
| JPH0293610U (en) * | 1989-01-09 | 1990-07-25 | ||
| IL146190A0 (en) * | 1999-06-10 | 2002-07-25 | Bridge Pharma Inc | Dermal anesthetic agents |
| EP1658847A3 (en) * | 1999-06-10 | 2006-07-26 | Bridge Pharma, Inc. | Indane derivatives as dermal anesthetic agents |
| JP4660045B2 (en) | 1999-09-17 | 2011-03-30 | 松森 昭 | Prophylactic or therapeutic agent for myocarditis, dilated cardiomyopathy and heart failure comprising NF-κB inhibitor as an active ingredient |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| WO2008011161A2 (en) | 2006-07-21 | 2008-01-24 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
-
1973
- 1973-01-01 AR AR250138A patent/AR206505A1/en active
- 1973-03-01 GB GB998773*[A patent/GB1405444A/en not_active Expired
- 1973-09-13 IL IL43218A patent/IL43218A/en unknown
- 1973-09-14 CA CA180,979A patent/CA992547A/en not_active Expired
- 1973-09-17 DD DD175711A patent/DD109802A5/xx unknown
- 1973-09-17 ES ES418827A patent/ES418827A1/en not_active Expired
- 1973-09-17 NL NL737312776A patent/NL152246B/en not_active IP Right Cessation
- 1973-09-17 LU LU68426A patent/LU68426A1/xx unknown
- 1973-09-17 DD DD173520A patent/DD108277A5/xx unknown
- 1973-09-17 HU HUCI1409A patent/HU168018B/hu unknown
- 1973-09-17 CH CH1330973A patent/CH585690A5/xx not_active IP Right Cessation
- 1973-09-18 FR FR7333497A patent/FR2199988B1/fr not_active Expired
- 1973-09-18 JP JP10583673A patent/JPS5327263B2/ja not_active Expired
- 1973-09-18 MX MX146573U patent/MX3233E/en unknown
-
1974
- 1974-01-01 AR AR254383A patent/AR205891A1/en active
- 1974-01-01 AR AR254382A patent/AR204247A1/en active
-
1975
- 1975-02-05 AR AR257533A patent/AR203500A1/en active
- 1975-08-05 ES ES440030A patent/ES440030A1/en not_active Expired
- 1975-08-05 ES ES440029A patent/ES440029A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2346337A1 (en) | 1974-04-04 |
| ES440029A1 (en) | 1977-02-16 |
| IL43218A (en) | 1977-05-31 |
| IL43218A0 (en) | 1973-11-28 |
| LU68426A1 (en) | 1973-11-26 |
| JPS5327263B2 (en) | 1978-08-07 |
| ES418827A1 (en) | 1977-02-01 |
| FR2199988B1 (en) | 1977-11-25 |
| FR2199988A1 (en) | 1974-04-19 |
| MX3233E (en) | 1980-08-05 |
| AU6028373A (en) | 1975-03-13 |
| DD108277A5 (en) | 1974-09-12 |
| DD109802A5 (en) | 1974-11-20 |
| DE2346337B2 (en) | 1976-08-26 |
| NL152246B (en) | 1977-02-15 |
| JPS4969648A (en) | 1974-07-05 |
| AR204247A1 (en) | 1975-12-10 |
| NL7312776A (en) | 1974-03-20 |
| AR206505A1 (en) | 1976-07-30 |
| HU168018B (en) | 1976-02-28 |
| GB1405444A (en) | 1975-09-10 |
| CA992547A (en) | 1976-07-06 |
| CH585690A5 (en) | 1977-03-15 |
| AR205891A1 (en) | 1976-06-15 |
| AR203500A1 (en) | 1975-09-15 |
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