ES401342A1 - Pyridine derivatives - Google Patents
Pyridine derivativesInfo
- Publication number
- ES401342A1 ES401342A1 ES401342A ES401342A ES401342A1 ES 401342 A1 ES401342 A1 ES 401342A1 ES 401342 A ES401342 A ES 401342A ES 401342 A ES401342 A ES 401342A ES 401342 A1 ES401342 A1 ES 401342A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- member selected
- pyridine
- formula
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003222 pyridines Chemical class 0.000 title abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Preparation process for derivatives of the pyridine of formula I and its acid addition salts **(See formula)** in which R1 is a member selected from the group consisting of a hydrogen atom and a methyl group, R2 is a member selected from the group consisting of a hydrogen atom, an alkali metal atom, an alkyl group containing from 1 to 3 carbon atoms, an alkyl group substituted with a hydroxyl group and containing from 1 to 3 atoms of carbon, a benzyl group and a benzyl group substituted with a halogen atom, and A is a member selected from the group consisting of groups - (CH2) n-, where n represents an integer greater than 1-1 and less than +2, characterized in that in order to obtain said new pyridine derivatives a pyridine derivative of general formula II is reacted: **(See formula)** wherein R1 and A have the same meanings as above and R3 is a member selected from the group consisting of halogen atom, hydroxyl group, amino group, and straight and branched chain alkoxy groups containing 1 to 4 carbon atoms, with a piperazine derivative of general formula III: **(See formula)** where R2 has the same meanings as above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUEE1907A HU162396B (en) | 1971-03-31 | 1971-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES401342A1 true ES401342A1 (en) | 1975-02-16 |
Family
ID=10995361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES401342A Expired ES401342A1 (en) | 1971-03-31 | 1972-03-29 | Pyridine derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5144957B1 (en) |
| AT (1) | AT316549B (en) |
| AU (1) | AU464287B2 (en) |
| BE (1) | BE781494A (en) |
| CA (1) | CA1024147A (en) |
| CH (1) | CH574438A5 (en) |
| CS (1) | CS166043B2 (en) |
| DK (1) | DK143500C (en) |
| ES (1) | ES401342A1 (en) |
| FI (1) | FI54709C (en) |
| FR (1) | FR2132136B1 (en) |
| GB (1) | GB1378964A (en) |
| HU (1) | HU162396B (en) |
| IL (1) | IL39058A (en) |
| NL (1) | NL164853C (en) |
| PL (1) | PL94559B1 (en) |
| SE (1) | SE396219B (en) |
| SU (1) | SU512712A3 (en) |
| YU (1) | YU35015B (en) |
| ZA (1) | ZA721972B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2156763C2 (en) * | 1994-07-15 | 2000-09-27 | Мейдзи Сейка Кабусики Кайся | Nitrogen-containing heterocyclic derivatives, pharmaceutical composition based on said and method of treatment or prophylaxis of thrombotic diseases |
| BR0209932A (en) | 2001-05-22 | 2004-10-13 | Neurogen Corp | Pharmaceutically acceptable compound or salt thereof, pharmaceutical composition, packaged pharmaceutical preparation, methods for modulating mch binding to an mch receptor and mvc, to alter the signal transduction activity of an mch receptor in a cell, to treat a disease or disorder associated with pathogenic obesity mch receptor activation and to determine the presence or absence of mch receptor in a sample, and use of a compound |
| WO2005110982A2 (en) | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
| MX339668B (en) * | 2006-05-30 | 2016-06-02 | Janssen Pharmaceutica N V * | Substituted pyridyl amide compounds as modulators of the histamine h3 receptor. |
-
1971
- 1971-03-31 HU HUEE1907A patent/HU162396B/hu unknown
-
1972
- 1972-03-22 FI FI795/72A patent/FI54709C/en active
- 1972-03-22 IL IL39058A patent/IL39058A/en unknown
- 1972-03-22 ZA ZA721972A patent/ZA721972B/en unknown
- 1972-03-28 FR FR7210851A patent/FR2132136B1/fr not_active Expired
- 1972-03-28 PL PL1972154378A patent/PL94559B1/en unknown
- 1972-03-29 GB GB1488772A patent/GB1378964A/en not_active Expired
- 1972-03-29 DK DK154272A patent/DK143500C/en not_active IP Right Cessation
- 1972-03-29 SE SE7204168A patent/SE396219B/en unknown
- 1972-03-29 YU YU848/72A patent/YU35015B/en unknown
- 1972-03-29 ES ES401342A patent/ES401342A1/en not_active Expired
- 1972-03-29 AU AU40515/72A patent/AU464287B2/en not_active Expired
- 1972-03-30 SU SU1766171A patent/SU512712A3/en active
- 1972-03-30 CH CH478072A patent/CH574438A5/xx not_active IP Right Cessation
- 1972-03-30 BE BE781494A patent/BE781494A/en not_active IP Right Cessation
- 1972-03-30 NL NL7204296.A patent/NL164853C/en not_active IP Right Cessation
- 1972-03-30 CA CA138,620A patent/CA1024147A/en not_active Expired
- 1972-03-31 CS CS2183A patent/CS166043B2/cs unknown
- 1972-03-31 AT AT284872A patent/AT316549B/en not_active IP Right Cessation
- 1972-03-31 JP JP47031839A patent/JPS5144957B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK143500C (en) | 1982-01-18 |
| CH574438A5 (en) | 1976-04-15 |
| CA1024147A (en) | 1978-01-10 |
| IL39058A (en) | 1975-07-28 |
| FR2132136B1 (en) | 1975-04-25 |
| FI54709B (en) | 1978-10-31 |
| CS166043B2 (en) | 1976-01-29 |
| SE396219B (en) | 1977-09-12 |
| AT316549B (en) | 1974-07-10 |
| DE2215545A1 (en) | 1972-10-12 |
| GB1378964A (en) | 1975-01-02 |
| JPS5144957B1 (en) | 1976-12-01 |
| IL39058A0 (en) | 1972-05-30 |
| DE2215545B2 (en) | 1975-07-31 |
| YU35015B (en) | 1980-06-30 |
| FR2132136A1 (en) | 1972-11-17 |
| YU84872A (en) | 1979-12-31 |
| SU512712A3 (en) | 1976-04-30 |
| ZA721972B (en) | 1973-01-31 |
| PL94559B1 (en) | 1977-08-31 |
| NL164853C (en) | 1981-02-16 |
| NL164853B (en) | 1980-09-15 |
| NL7204296A (en) | 1972-10-03 |
| DK143500B (en) | 1981-08-31 |
| BE781494A (en) | 1972-07-17 |
| FI54709C (en) | 1979-02-12 |
| HU162396B (en) | 1973-02-28 |
| AU464287B2 (en) | 1975-08-05 |
| AU4051572A (en) | 1974-03-07 |
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