ES403125A1 - Procedimiento para la obtencion de una composicion antibac-teriana. - Google Patents
Procedimiento para la obtencion de una composicion antibac-teriana.Info
- Publication number
- ES403125A1 ES403125A1 ES403125A ES403125A ES403125A1 ES 403125 A1 ES403125 A1 ES 403125A1 ES 403125 A ES403125 A ES 403125A ES 403125 A ES403125 A ES 403125A ES 403125 A1 ES403125 A1 ES 403125A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- procedure
- obtaining
- formula
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Fodder In General (AREA)
Abstract
Procedimiento para la obtención de una composición antibacteriana, caracterizado porque en una primera etapa se prepara una penicilina de fórmula general I. **fórmula** en la que R es fenilo, R'' es metilo y R''` es dimetilamino y en cuyos compuestos, en cuanto eal centro de quiralidad C*, pueden presentarse en las dos posibles configuraciones R y S y como mezclas de los diastereómeros de ellas resultantes, así como las sales atóxicas farmacéuticamente tolerables de estos compuestos , haciendo reaccionar un compuesto de fórmula general II **fórmula** en la que R se define como anteriormente , con un compuesto de fórmula general III **fórmula** en la que R'' y R''` se definen como anteriormente, y W representa halógeno o azido, efectuándose la reacción en disolvente anhidros o acuosos, en presencia de una base, y en una segunda etapa se mezcla la penicilina resultante con un vehículo farmacéuticamente aceptable.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2025414A DE2025414C3 (de) | 1970-05-25 | 1970-05-25 | Cyclische Acylureidophenylacetamidopenicillansäuren |
| DE19712104580 DE2104580C3 (de) | 1971-02-01 | 1971-02-01 | Acylureidopenicilline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES403125A1 true ES403125A1 (es) | 1975-12-16 |
Family
ID=25759178
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391532A Expired ES391532A1 (es) | 1970-05-25 | 1971-05-25 | Procedimiento para la obtencion de penicilinas. |
| ES403126A Expired ES403126A1 (es) | 1970-05-25 | 1972-05-24 | Procedimiento para la obtencion de una composicion antibac-teriana. |
| ES403124A Expired ES403124A1 (es) | 1970-05-25 | 1972-05-24 | Procedimiento para la obtencion de una composicion antibac-teriana. |
| ES403125A Expired ES403125A1 (es) | 1970-05-25 | 1972-05-24 | Procedimiento para la obtencion de una composicion antibac-teriana. |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391532A Expired ES391532A1 (es) | 1970-05-25 | 1971-05-25 | Procedimiento para la obtencion de penicilinas. |
| ES403126A Expired ES403126A1 (es) | 1970-05-25 | 1972-05-24 | Procedimiento para la obtencion de una composicion antibac-teriana. |
| ES403124A Expired ES403124A1 (es) | 1970-05-25 | 1972-05-24 | Procedimiento para la obtencion de una composicion antibac-teriana. |
Country Status (28)
| Country | Link |
|---|---|
| JP (1) | JPS5538357B1 (es) |
| AR (2) | AR195267A1 (es) |
| AT (1) | AT307617B (es) |
| BE (1) | BE767647A (es) |
| BG (1) | BG23220A3 (es) |
| CA (1) | CA943128A (es) |
| CH (1) | CH562249A5 (es) |
| CS (1) | CS171230B2 (es) |
| CY (1) | CY829A (es) |
| DD (1) | DD91497B3 (es) |
| DK (1) | DK133679C (es) |
| EG (1) | EG10856A (es) |
| ES (4) | ES391532A1 (es) |
| FI (1) | FI54484C (es) |
| FR (1) | FR2100681B1 (es) |
| GB (1) | GB1301961A (es) |
| HU (1) | HU162205B (es) |
| IE (1) | IE35311B1 (es) |
| IL (1) | IL36905A (es) |
| KE (1) | KE2592A (es) |
| LU (1) | LU63203A1 (es) |
| NL (1) | NL172660C (es) |
| NO (1) | NO141164C (es) |
| PH (1) | PH14794A (es) |
| RO (2) | RO59157A (es) |
| SE (1) | SE395896B (es) |
| SU (1) | SU472507A3 (es) |
| YU (1) | YU130271A (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2354219A1 (de) * | 1973-10-30 | 1975-05-07 | Bayer Ag | Beta-lactam-antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4039673A (en) | 1973-10-30 | 1977-08-02 | Bayer Aktiengesellschaft | Penicillins and cephalosporins and their production |
| GB1486349A (en) * | 1974-11-28 | 1977-09-21 | Bayer Ag | Beta-lactam antibiotics process for their preparation and their use as medicaments |
| GB1584400A (en) * | 1976-12-24 | 1981-02-11 | Bayer Ag | (2-oxo-imidazoliden-1-yl(carbonylamino)-acetamido-cephalosporins and penicillins |
| DE2658906A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Beta-lactam-antibiotika, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| CA1133896A (en) * | 1978-05-26 | 1982-10-19 | Nobuhiro Oi | Penicillanic acid derivative and process for preparing the same |
| JPS5732289A (en) | 1980-08-05 | 1982-02-20 | Chugai Pharmaceut Co Ltd | Alpha-substituted ureidobenzylpenicillin |
-
1971
- 1971-04-23 CH CH599071A patent/CH562249A5/xx not_active IP Right Cessation
- 1971-05-13 BG BG017580A patent/BG23220A3/xx unknown
- 1971-05-19 CS CS3646A patent/CS171230B2/cs unknown
- 1971-05-19 EG EG209/71A patent/EG10856A/xx active
- 1971-05-20 SU SU1661304A patent/SU472507A3/ru active
- 1971-05-21 FI FI1401/71A patent/FI54484C/fi active
- 1971-05-21 IE IE643/71A patent/IE35311B1/xx unknown
- 1971-05-21 LU LU63203D patent/LU63203A1/xx unknown
- 1971-05-24 PH PH12493A patent/PH14794A/en unknown
- 1971-05-24 SE SE7106667A patent/SE395896B/xx unknown
- 1971-05-24 IL IL7136905A patent/IL36905A/xx unknown
- 1971-05-24 DD DD71155301A patent/DD91497B3/de unknown
- 1971-05-24 YU YU01302/71A patent/YU130271A/xx unknown
- 1971-05-24 NO NO1945/71A patent/NO141164C/no unknown
- 1971-05-24 DK DK251071A patent/DK133679C/da active
- 1971-05-24 AR AR235756A patent/AR195267A1/es active
- 1971-05-25 CY CY829A patent/CY829A/xx unknown
- 1971-05-25 HU HUBA2591A patent/HU162205B/hu unknown
- 1971-05-25 GB GB1688071A patent/GB1301961A/en not_active Expired
- 1971-05-25 JP JP3524471A patent/JPS5538357B1/ja active Pending
- 1971-05-25 RO RO67014A patent/RO59157A/ro unknown
- 1971-05-25 CA CA113,784A patent/CA943128A/en not_active Expired
- 1971-05-25 NL NLAANVRAGE7107175,A patent/NL172660C/xx not_active IP Right Cessation
- 1971-05-25 FR FR7118932A patent/FR2100681B1/fr not_active Expired
- 1971-05-25 ES ES391532A patent/ES391532A1/es not_active Expired
- 1971-05-25 AT AT450471A patent/AT307617B/de not_active IP Right Cessation
- 1971-05-25 RO RO7100078134A patent/RO62689A/ro unknown
- 1971-05-25 BE BE767647A patent/BE767647A/xx not_active IP Right Cessation
-
1972
- 1972-05-24 ES ES403126A patent/ES403126A1/es not_active Expired
- 1972-05-24 ES ES403124A patent/ES403124A1/es not_active Expired
- 1972-05-24 ES ES403125A patent/ES403125A1/es not_active Expired
-
1973
- 1973-09-14 AR AR250097A patent/AR195946A1/es active
-
1975
- 1975-12-22 KE KE2592*UA patent/KE2592A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19910221 |