ES403373A2 - Procedure for the preparation of N- (furil-methyl) morphinanes. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of N- (furil-methyl) morphinanes. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES403373A2 ES403373A2 ES403373A ES403373A ES403373A2 ES 403373 A2 ES403373 A2 ES 403373A2 ES 403373 A ES403373 A ES 403373A ES 403373 A ES403373 A ES 403373A ES 403373 A2 ES403373 A2 ES 403373A2
- Authority
- ES
- Spain
- Prior art keywords
- formula
- methyl
- hydrogen atom
- signifies
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003810 morphinanes Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical compound C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
Abstract
Improvements introduced in the object of the main patent No. 399,875, applied for on February 17, 1972, for: "Procedure for the preparation of N- (furyl-methyl) -morphonanes" of the general formula **(See formula)** wherein R signifies a hydrogen atom or a methyl or acetyl group and R1 signifies a hydrogen atom or a methyl or ethyl group, and of their acid addition salts, characterized in that a morphinan of the formula is reacted **(See formula)** wherein R'means a hydrogen atom, an alcohol, aralcohyl or acyl group, with a quaternary ammonium salt of the formula **(See formula)** wherein Z signifies a hydrogen atom, a methyl or ethyl group, or a substituent that can be transformed by chemical reaction into a hydrogen atom or a methyl or ethyl group, and A signifies the anion of an organic or inorganic acid, to form a compound of the formula **(See formula)** in which R'and Z have the meanings mentioned above; and if compounds of formula IV are obtained, in which Z does not have the meaning of R1-the substituent Z is transformed by chemical reaction into a hydrogen atom or a methyl or ethyl group; and if desired - for the preparation of a compound of the formula I, in which R signifies a hydrogen atom, a compound of the formula is dealkoxylated or deacylated **(See formula)** where R1 has the meanings mentioned above and R'means an alcoholic, aralcohyl or acyl group; and if desired - for the preparation of a compound of the formula I, in which R means a methyl or acetyl group - a compound of the formula IVa is methylated or acetylated, in which R1 has the aforementioned meanings and R' designates a hydrogen atom, and eventually the compounds of the general formula I are transformed into their physiologically harmless acid addition salts. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES403373A ES403373A2 (en) | 1972-05-31 | 1972-05-31 | Procedure for the preparation of N- (furil-methyl) morphinanes. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES403373A ES403373A2 (en) | 1972-05-31 | 1972-05-31 | Procedure for the preparation of N- (furil-methyl) morphinanes. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES403373A2 true ES403373A2 (en) | 1977-06-16 |
Family
ID=8461315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES403373A Expired ES403373A2 (en) | 1972-05-31 | 1972-05-31 | Procedure for the preparation of N- (furil-methyl) morphinanes. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES403373A2 (en) |
-
1972
- 1972-05-31 ES ES403373A patent/ES403373A2/en not_active Expired
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