ES410069A1 - A PROCEDURE FOR THE PRODUCTION OF 7-ACILAMIDO 3-CEFEM-4-CARBOXYL ACIDS. - Google Patents

Abstract

A process for the production of 7-acylamido-3-cephem-4-carboxylic acids represented by the following general formula **(See formula)** wherein R1 represents a hydrogen atom, a halogen atom, an azido, acyloxy, alkyloxy, aryloxy group, or S-R'(R' represents an alkyl, aralkyl, aryl group or a heterocyclic group); R2 represents a hydrogen atom, a substituted or unsubstituted alkyl, aryl, cycloalkyl, cycloalkenyl or heterocyclic group; R3 represents the same as R or a halogen atom, a cyano, hydroxy, azido group, or Y-R'' (Y represents O, S, NH or COO, R'' represents an alkyl, aryl, aralkyl group, or a heterocyclic group); or R2 and R3 may together form a ring; and R4 represents a hydrogen atom or an amino group, said process consisting of reacting the salts of 7-amino-3-cephem-4-carboxylic acids of the following general formula, **(See formula)** wherein R1 is the same as defined above, with reactive carboxylic acid derivatives of the following general formula, **(See formula)** wherein R5 represents a hydrogen atom or a protected amino group in the form of a salt or a protected amino group in the N position, and R2, R3 are the same as defined above, in the presence of alcohols as a solvent medium, to produce the compound of the following general formula **(See formula)** wherein the symbols are the same as defined above, and then removing the protecting group from amino function, when R5 represents a protected amino group in the form of a salt or a protected amino group in the N position. (Machine-translation by Google Translate, not legally binding)