ES411208A1 - Un metodo de preparacion de una sal no toxica del cation n-m-metoxibencil-n, n-dimetil-n-2-etilamonio. - Google Patents
Un metodo de preparacion de una sal no toxica del cation n-m-metoxibencil-n, n-dimetil-n-2-etilamonio.Info
- Publication number
- ES411208A1 ES411208A1 ES411208A ES411208A ES411208A1 ES 411208 A1 ES411208 A1 ES 411208A1 ES 411208 A ES411208 A ES 411208A ES 411208 A ES411208 A ES 411208A ES 411208 A1 ES411208 A1 ES 411208A1
- Authority
- ES
- Spain
- Prior art keywords
- dimethyl
- methoxy
- benzyl
- hydroxyethyl ammonium
- cardiac fibrillation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RTFPZPQHACJTLS-UHFFFAOYSA-N benzyl-(2-hydroxy-2-methoxyethyl)-dimethylazanium Chemical compound COC(C[N+](C)(C)CC1=CC=CC=C1)O RTFPZPQHACJTLS-UHFFFAOYSA-N 0.000 title 1
- 206010061592 cardiac fibrillation Diseases 0.000 title 1
- 206010003658 Atrial Fibrillation Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002270 dispersing agent Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- -1 sachets Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 abstract 1
- 208000003663 ventricular fibrillation Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Compuestos que contienen el catión N-m-metoxi-bencil-N,N-dimetil-N-etilamonio o el catión N-m-metoxi-bencil-N,N-dimetil-N-2-hidroxictilamonio poseen ventajas inesperadas sobre la droga citada en el tratamiento de la arritmia. Estos compuestos no sólo poseen propiedades anti-arrítmicas comparables a las del bretylium, sino que poseen además una acción del bloqueo simpática apreciablemente menor, haciendo así posible el tratamiento de las alteraciones cardíacas con poco o ningún efecto adverso sobre la presión sanguínea.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3168669 | 1969-06-23 | ||
| GB5923069 | 1969-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES411208A1 true ES411208A1 (es) | 1975-12-01 |
Family
ID=26261039
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES381019A Expired ES381019A1 (es) | 1969-06-23 | 1970-06-22 | Un metodo para preparar una sal del cation n-m-metoxibenciln,n - dimetil-n-2-hidroxietilamonio. |
| ES411208A Expired ES411208A1 (es) | 1969-06-23 | 1973-02-02 | Un metodo de preparacion de una sal no toxica del cation n-m-metoxibencil-n, n-dimetil-n-2-etilamonio. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES381019A Expired ES381019A1 (es) | 1969-06-23 | 1970-06-22 | Un metodo para preparar una sal del cation n-m-metoxibenciln,n - dimetil-n-2-hidroxietilamonio. |
Country Status (12)
| Country | Link |
|---|---|
| JP (2) | JPS5312502B1 (es) |
| BE (1) | BE752415A (es) |
| CA (1) | CA979016A (es) |
| CH (1) | CH540226A (es) |
| DE (1) | DE2030692C3 (es) |
| DK (1) | DK145155C (es) |
| ES (2) | ES381019A1 (es) |
| FI (1) | FI54598C (es) |
| FR (1) | FR2053006A1 (es) |
| IL (1) | IL34765A (es) |
| NL (1) | NL162063C (es) |
| SE (1) | SE397342B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4765826A (en) * | 1986-05-19 | 1988-08-23 | The Dow Chemical Company | Substituted benzyltrialkylammonium salts and their use as plant growth enhancers |
-
1970
- 1970-06-21 IL IL34765A patent/IL34765A/en unknown
- 1970-06-22 JP JP5430570A patent/JPS5312502B1/ja active Pending
- 1970-06-22 DK DK322470A patent/DK145155C/da not_active IP Right Cessation
- 1970-06-22 ES ES381019A patent/ES381019A1/es not_active Expired
- 1970-06-22 SE SE7008563A patent/SE397342B/xx unknown
- 1970-06-22 DE DE2030692A patent/DE2030692C3/de not_active Expired
- 1970-06-22 FI FI1740/70A patent/FI54598C/fi active
- 1970-06-23 NL NL7009186.A patent/NL162063C/xx not_active IP Right Cessation
- 1970-06-23 CA CA086,352A patent/CA979016A/en not_active Expired
- 1970-06-23 FR FR7023110A patent/FR2053006A1/fr active Granted
- 1970-06-23 BE BE752415D patent/BE752415A/xx not_active IP Right Cessation
- 1970-06-23 CH CH949570A patent/CH540226A/de not_active IP Right Cessation
-
1973
- 1973-02-02 ES ES411208A patent/ES411208A1/es not_active Expired
-
1977
- 1977-04-01 JP JP3744077A patent/JPS5540574B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH540226A (de) | 1973-08-15 |
| IL34765A (en) | 1974-12-31 |
| DK145155B (da) | 1982-09-20 |
| BE752415A (fr) | 1970-12-23 |
| NL7009186A (es) | 1970-12-28 |
| FI54598C (fi) | 1979-01-10 |
| SE397342B (sv) | 1977-10-31 |
| NL162063B (nl) | 1979-11-15 |
| NL162063C (nl) | 1980-04-15 |
| DE2030692C3 (de) | 1981-04-23 |
| DE2030692B2 (de) | 1980-07-10 |
| FR2053006B1 (es) | 1974-02-22 |
| FI54598B (fi) | 1978-09-29 |
| ES381019A1 (es) | 1972-10-16 |
| DE2030692A1 (de) | 1971-01-21 |
| FR2053006A1 (en) | 1971-04-16 |
| JPS5312502B1 (es) | 1978-05-01 |
| IL34765A0 (en) | 1970-08-19 |
| DK145155C (da) | 1983-02-21 |
| JPS5540574B1 (es) | 1980-10-18 |
| CA979016A (en) | 1975-12-02 |
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