ES411331A1 - Procedure for the obtaining of 4 and 5-nitroimidazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of 4 and 5-nitroimidazoles. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES411331A1 ES411331A1 ES411331A ES411331A ES411331A1 ES 411331 A1 ES411331 A1 ES 411331A1 ES 411331 A ES411331 A ES 411331A ES 411331 A ES411331 A ES 411331A ES 411331 A1 ES411331 A1 ES 411331A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- lower alkyl
- see formula
- signifies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004958 5-nitroimidazoles Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 150000004960 4-nitroimidazoles Chemical class 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000000464 thioxo group Chemical group S=* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining 4- and 5-nitroimidazoles of formula I **(See formula)** wherein one of the radicals R1 and R2 signifies hydrogen or lower alkyl and the other is a nitro group, R3 signifies hydrogen or lower alkyl, optionally substituted, R4 signifies oxo or thioxo, R5 signifies heteroaryl and R6 and R7 are independent of yes, hydrogen or lower alkyl, or together, means the remaining part of a condensed benzene nucleus, if substituted, and of its salts, characterized in that a compound of formula II **(See formula)** it is condensed with a compound of formula III, or a tautomeric compound of formula IIIa **(See formula)** where R1, R2, R3, R4, R5, R6 and R7 have the indicated meanings, R'4 means an oxygen atom or, first of all, a sulfur atom and X and Y represent dissociable residues leaving a direct bond, or a compound of formula IV **(See formula)** where R3, R4, R5, R6 and R7 have the indicated meanings and at least one of the residues R'1 and R'2 means hydrogen and the other can also be lower alkyl, nitrate, or a compound of formula V **(See formula)** where R1, R2, R3, R5, R6 and R7 have the indicated meanings and R'4 represents an oxygen or sulfur atom, isomerizes, or in a compound of formula VI **(See formula)** where R1, R2, R3, R6 and R7 have the indicated meanings and R is lower alkyl, the -SR group is hydrolyzed to the oxo group and, if desired, in the compounds obtained, within the range of the definition of the final products, the substituents are introduced, modified or dissociated, and/or the racemate mixture, if obtained, is cleaved in the pure racemates and/or the racemates, if obtained, are separated into the optical antipodes and/or the salts, if appropriate obtained are transformed into the free bases or the free bases obtained are transformed into their salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH181072A CH570399A5 (en) | 1972-02-08 | 1972-02-08 | 4-or-5-nitro-imidazole derivs - with antibacterial, antiprotozoal and anthelmintic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES411331A1 true ES411331A1 (en) | 1976-06-16 |
Family
ID=4219133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES411331A Expired ES411331A1 (en) | 1972-02-08 | 1973-02-06 | Procedure for the obtaining of 4 and 5-nitroimidazoles. (Machine-translation by Google Translate, not legally binding) |
Country Status (5)
| Country | Link |
|---|---|
| AU (1) | AU5184273A (en) |
| CH (1) | CH570399A5 (en) |
| CS (1) | CS185209B2 (en) |
| ES (1) | ES411331A1 (en) |
| ZA (1) | ZA73598B (en) |
-
1972
- 1972-02-08 CH CH181072A patent/CH570399A5/en not_active IP Right Cessation
-
1973
- 1973-01-26 ZA ZA730598A patent/ZA73598B/en unknown
- 1973-02-06 AU AU51842/73A patent/AU5184273A/en not_active Expired
- 1973-02-06 ES ES411331A patent/ES411331A1/en not_active Expired
- 1973-02-07 CS CS7300000900A patent/CS185209B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5184273A (en) | 1974-08-08 |
| CS185209B2 (en) | 1978-09-15 |
| ZA73598B (en) | 1973-10-31 |
| CH570399A5 (en) | 1975-12-15 |
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