ES413279A1 - Pyridine derivatives having hypoglycaemic activity - Google Patents

Pyridine derivatives having hypoglycaemic activity

Info

Publication number
ES413279A1
ES413279A1 ES413279A ES413279A ES413279A1 ES 413279 A1 ES413279 A1 ES 413279A1 ES 413279 A ES413279 A ES 413279A ES 413279 A ES413279 A ES 413279A ES 413279 A1 ES413279 A1 ES 413279A1
Authority
ES
Spain
Prior art keywords
group
formula
alk
carboxylic acid
pyridyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES413279A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robapharm AG
Original Assignee
Robapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robapharm AG filed Critical Robapharm AG
Publication of ES413279A1 publication Critical patent/ES413279A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of biologically active compounds in the treatment of hypoglycemia of the formula (I) or (II) **(See formula)** in whose formulas "Py" represents a substituted or unsubstituted, 2-, 3- or 4-pyridyl N-oxidized or quaternized pyridyl group; "A" represents a group of the formula (IIIA), (IIIB) or (IIIC) **(See formula)** in which "ALK" represents a straight or branched chain alkylene group with 1 to 6 carbon atoms; R1 represents a carboxylic acid group, a group that is converted in the human body to a carboxylic acid group or an acyl group; R2, R3 and R4 each represent hydrogen, a carboxylic acid group, a group that converts in the human body to a carboxylic acid group, an acyl group, a hydroxy group, an alkoxy group, an aralkoxy group, an aryloxy group, a halogen group or an amino group, except that it is not methyl, cyano or methoxycarbonyl when "Py" is 2-pyridyl or 5-ethylpyrid-2-yl and A is - [O-CH2] - and R2, R3 and R4 are hydrogen or halogen; or one of its pharmaceutically acceptable salts, characterized by condensing a compound of the formula (IV) with a compound of the formula (V) (IV) B - (Alk) nOH HO- (Alk) m-Py (V) in which n and m are 0 or 1, provided that n + m is not zero and "ALK" and "Py" have the meaning indicated in relation to formula (I) or (II) and the symbol B represents a group of the formula (IA) or (IIA) **(See formula)** in which R1, R2, R3 and R4 have the indicated meaning in relation to formula (I) or (II). (Machine-translation by Google Translate, not legally binding)
ES413279A 1972-04-04 1973-04-03 Pyridine derivatives having hypoglycaemic activity Expired ES413279A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1528072A GB1437781A (en) 1972-04-04 1972-04-04 Pyridine derivatives having hypoglycaemic activity

Publications (1)

Publication Number Publication Date
ES413279A1 true ES413279A1 (en) 1976-01-01

Family

ID=10056262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES413279A Expired ES413279A1 (en) 1972-04-04 1973-04-03 Pyridine derivatives having hypoglycaemic activity

Country Status (20)

Country Link
JP (1) JPS49100091A (en)
AR (1) AR208269A1 (en)
AT (1) AT339301B (en)
BE (1) BE797715A (en)
BG (1) BG20352A3 (en)
CA (1) CA999868A (en)
CH (1) CH576961A5 (en)
CS (1) CS183689B2 (en)
DD (1) DD106834A5 (en)
DE (1) DE2316881A1 (en)
ES (1) ES413279A1 (en)
FR (1) FR2182933B1 (en)
GB (1) GB1437781A (en)
HU (1) HU165731B (en)
IE (1) IE37412B1 (en)
IL (1) IL41825A (en)
NL (1) NL7304610A (en)
PL (1) PL96043B1 (en)
RO (2) RO63069A (en)
ZA (1) ZA731853B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4409227A (en) 1979-08-09 1983-10-11 The Dow Chemical Co. 4-(((Heterocyclo)thio)methyl)benzoic acids, esters and amides and their pharmaceutical use
ES2072085T3 (en) * 1991-07-03 1995-07-01 Unilever Nv IMPROVED CHOCOLATE COMPOSITIONS.
EP0521549B1 (en) * 1991-07-03 1995-08-23 Unilever N.V. Chocolate fillings containing anti-bloom additive
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
US6043247A (en) * 1996-04-19 2000-03-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
JP2000509373A (en) * 1996-04-19 2000-07-25 ノボ ノルディスク アクティーゼルスカブ Modulators of molecules with phosphotyrosine recognition units
US6329372B1 (en) 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
JP2002504534A (en) 1998-02-26 2002-02-12 セルテック・セラピューティクス・リミテッド Phenylalanine derivatives as inhibitors of α4 integrin
GB9805655D0 (en) 1998-03-16 1998-05-13 Celltech Therapeutics Ltd Chemical compounds
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds
GB9811969D0 (en) 1998-06-03 1998-07-29 Celltech Therapeutics Ltd Chemical compounds
GB9812088D0 (en) 1998-06-05 1998-08-05 Celltech Therapeutics Ltd Chemical compounds
GB9814414D0 (en) * 1998-07-03 1998-09-02 Celltech Therapeutics Ltd Chemical compounds
GB9821061D0 (en) 1998-09-28 1998-11-18 Celltech Therapeutics Ltd Chemical compounds
GB9821222D0 (en) 1998-09-30 1998-11-25 Celltech Therapeutics Ltd Chemical compounds
GB9825652D0 (en) 1998-11-23 1999-01-13 Celltech Therapeutics Ltd Chemical compounds
GB9826174D0 (en) 1998-11-30 1999-01-20 Celltech Therapeutics Ltd Chemical compounds
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
US6534513B1 (en) 1999-09-29 2003-03-18 Celltech R&D Limited Phenylalkanoic acid derivatives
US6455539B2 (en) 1999-12-23 2002-09-24 Celltech R&D Limited Squaric acid derivates
DE60130910T2 (en) 2000-04-17 2008-07-10 Ucb Pharma, S.A. ENAMINE DERIVATIVES AS CELL ADHESION MOLECULES
US6403608B1 (en) 2000-05-30 2002-06-11 Celltech R&D, Ltd. 3-Substituted isoquinolin-1-yl derivatives
US6545013B2 (en) 2000-05-30 2003-04-08 Celltech R&D Limited 2,7-naphthyridine derivatives
WO2002004426A1 (en) 2000-07-07 2002-01-17 Celltech R & D Limited Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists
CA2417059A1 (en) 2000-08-02 2002-02-07 Celltech R&D Limited 3-substituted isoquinolin-1-yl derivatives
RU2341513C2 (en) * 2001-06-12 2008-12-20 Веллстат Терапьютикс Корпорейшн Compounds for treatment of metabolic diseases
GB0405033D0 (en) * 2004-03-05 2004-04-07 Karobio Ab Novel pharmaceutical compositions
TWI490214B (en) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 Benzene or thiophene derivative and use thereof as vap-1 inhibitor
AR074760A1 (en) * 2008-12-18 2011-02-09 Metabolex Inc GPR120 RECEIVER AGONISTS AND USES OF THE SAME IN MEDICINES FOR THE TREATMENT OF DIABETES AND METABOLIC SYNDROME.
EP3019034B1 (en) 2013-07-01 2018-10-31 Givaudan SA Organic compounds
WO2016167153A1 (en) * 2015-04-15 2016-10-20 長谷川香料株式会社 Flavor modulator having pyridine derivative or salt thereof as active ingredient
EP3440052B1 (en) * 2016-04-06 2023-10-25 University Of Oulu Compounds for use in the treatment of cancer

Also Published As

Publication number Publication date
BG20352A3 (en) 1975-11-05
FR2182933A1 (en) 1973-12-14
GB1437781A (en) 1976-06-03
IE37412B1 (en) 1977-07-20
CS183689B2 (en) 1978-07-31
IL41825A (en) 1977-03-31
IE37412L (en) 1973-10-04
RO62274A (en) 1977-12-15
BE797715A (en) 1973-10-03
NL7304610A (en) 1973-10-08
JPS49100091A (en) 1974-09-20
FR2182933B1 (en) 1976-05-14
CH576961A5 (en) 1976-06-30
ZA731853B (en) 1974-01-30
AT339301B (en) 1977-10-10
IL41825A0 (en) 1973-05-31
ATA286773A (en) 1977-02-15
RO63069A (en) 1978-08-15
DD106834A5 (en) 1974-07-05
PL96043B1 (en) 1977-11-30
DE2316881A1 (en) 1973-10-11
HU165731B (en) 1974-10-28
CA999868A (en) 1976-11-16
AR208269A1 (en) 1976-12-20

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