ES413441A1 - A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding) - Google Patents
A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES413441A1 ES413441A1 ES413441A ES413441A ES413441A1 ES 413441 A1 ES413441 A1 ES 413441A1 ES 413441 A ES413441 A ES 413441A ES 413441 A ES413441 A ES 413441A ES 413441 A1 ES413441 A1 ES 413441A1
- Authority
- ES
- Spain
- Prior art keywords
- translation
- production
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940047526 cephalexin monohydrate Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- YGZIWEZFFBPCLN-UHFFFAOYSA-N n,3-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2$l^{5}-oxazaphosphinan-2-amine Chemical compound OOC1CCOP(=O)(NCCCl)N1CCCl YGZIWEZFFBPCLN-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000002051 biphasic effect Effects 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
- 239000007791 liquid phase Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
A process for the production of the crystalline and relatively water-insoluble form of cephalexin monohydrate, whose process is characterized in that it consists of preparing an acidic, concentrated aqueous solution of cephalexin with a ph of less than 2.4, adding enough N-butanol to form two liquid phases and then slowly neutralizing said biphasic system, up to about ph 4.0 to 5.0 at a temperature not higher than 45ºC to precipitate the water-insoluble crystalline form of cephalexin monohydrate. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES413441A ES413441A1 (en) | 1973-04-06 | 1973-04-06 | A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES413441A ES413441A1 (en) | 1973-04-06 | 1973-04-06 | A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES413441A1 true ES413441A1 (en) | 1976-05-16 |
Family
ID=8463845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES413441A Expired ES413441A1 (en) | 1973-04-06 | 1973-04-06 | A process of production of the crystalline form and relatively insoluble in cephalexin monohydrate water. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES413441A1 (en) |
-
1973
- 1973-04-06 ES ES413441A patent/ES413441A1/en not_active Expired
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