ES379444A2 - A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES379444A2 ES379444A2 ES379444A ES379444A ES379444A2 ES 379444 A2 ES379444 A2 ES 379444A2 ES 379444 A ES379444 A ES 379444A ES 379444 A ES379444 A ES 379444A ES 379444 A2 ES379444 A2 ES 379444A2
- Authority
- ES
- Spain
- Prior art keywords
- translation
- machine
- legally binding
- google translate
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 2
- 229960002180 tetracycline Drugs 0.000 title abstract 2
- 229930101283 tetracycline Natural products 0.000 title abstract 2
- 235000019364 tetracycline Nutrition 0.000 title abstract 2
- 150000003522 tetracyclines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 abstract 2
- NSNHWTBQMQIDCF-UHFFFAOYSA-N dihydrate;hydrochloride Chemical compound O.O.Cl NSNHWTBQMQIDCF-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000002198 insoluble material Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Improvements introduced in the object of the main patent no. 277.406, issued on september 20, 1962 by: "a process for preparing tetracycline derivatives", characterized by forming a solution of 7-dimethylamino-6-demethyl-6-deoxytetracycline or a salt of it in water in the presence of chloride ion, reach a ph of the final solution of less than 1.5, separate any insoluble material, adjust the ph of the clarified solution to 3.5-4.0 with a base, as as a result of which the crystallization of 7-dimethylamino-6-demethyl-6-deoxytetracycline takes place in the form of the hydrochloride dihydrate, and thereafter recovering the hydrochloride dihydrate salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14713761A | 1961-10-24 | 1961-10-24 | |
| US161412A US3148212A (en) | 1961-12-22 | 1961-12-22 | Reductive alkylation process |
| US17159962A | 1962-02-07 | 1962-02-07 | |
| ES277406A ES277406A1 (en) | 1961-10-24 | 1962-05-17 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
| US53928266A | 1966-04-01 | 1966-04-01 | |
| US54436866A | 1966-04-22 | 1966-04-22 | |
| US58920666A | 1966-10-25 | 1966-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES379444A2 true ES379444A2 (en) | 1972-11-01 |
Family
ID=56089740
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES277406A Expired ES277406A1 (en) | 1961-10-24 | 1962-05-17 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
| ES338710A Expired ES338710A2 (en) | 1961-10-24 | 1967-03-31 | A procedure for preparing tetracycline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES379444A Expired ES379444A2 (en) | 1961-10-24 | 1970-05-08 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES277406A Expired ES277406A1 (en) | 1961-10-24 | 1962-05-17 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
| ES338710A Expired ES338710A2 (en) | 1961-10-24 | 1967-03-31 | A procedure for preparing tetracycline derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE618065A (en) |
| CH (2) | CH444848A (en) |
| DK (1) | DK126586B (en) |
| ES (3) | ES277406A1 (en) |
| GB (1) | GB1003474A (en) |
| LU (1) | LU41768A1 (en) |
| MC (1) | MC370A1 (en) |
| SE (1) | SE309416B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
-
1962
- 1962-05-16 MC MC389A patent/MC370A1/en unknown
- 1962-05-17 ES ES277406A patent/ES277406A1/en not_active Expired
- 1962-05-17 GB GB19034/62A patent/GB1003474A/en not_active Expired
- 1962-05-22 CH CH618162A patent/CH444848A/en unknown
- 1962-05-22 CH CH1577466A patent/CH448070A/en unknown
- 1962-05-24 BE BE618065A patent/BE618065A/en unknown
- 1962-05-24 LU LU41768D patent/LU41768A1/xx unknown
- 1962-05-24 DK DK235062AA patent/DK126586B/en unknown
-
1963
- 1963-11-22 SE SE12945/63A patent/SE309416B/xx unknown
-
1967
- 1967-03-31 ES ES338710A patent/ES338710A2/en not_active Expired
-
1970
- 1970-05-08 ES ES379444A patent/ES379444A2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1003474A (en) | 1965-09-02 |
| MC370A1 (en) | 1963-03-28 |
| SE309416B (en) | 1969-03-24 |
| BE618065A (en) | 1962-11-26 |
| DK126586B (en) | 1973-07-30 |
| ES277406A1 (en) | 1962-12-01 |
| CH444848A (en) | 1967-10-15 |
| LU41768A1 (en) | 1962-07-24 |
| CH448070A (en) | 1967-12-15 |
| ES338710A2 (en) | 1968-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD2A | Announcement of lapse in spain |
Effective date: 20170703 |