ES414802A1 - Substituted indolin-2-ones - Google Patents
Substituted indolin-2-onesInfo
- Publication number
- ES414802A1 ES414802A1 ES414802A ES414802A ES414802A1 ES 414802 A1 ES414802 A1 ES 414802A1 ES 414802 A ES414802 A ES 414802A ES 414802 A ES414802 A ES 414802A ES 414802 A1 ES414802 A1 ES 414802A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- defined above
- ones
- see formula
- see
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000005623 oxindoles Chemical class 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 2
- PZLOEWPWHWLNOZ-UHFFFAOYSA-N 1-benzoyl-3h-indol-2-one Chemical class O=C1CC2=CC=CC=C2N1C(=O)C1=CC=CC=C1 PZLOEWPWHWLNOZ-UHFFFAOYSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B45/00—Complex metal compounds of azo dyes
- C09B45/02—Preparation from dyes containing in o-position a hydroxy group and in o'-position hydroxy, alkoxy, carboxyl, amino or keto groups
- C09B45/24—Disazo or polyazo compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B35/00—Disazo and polyazo dyes of the type A<-D->B prepared by diazotising and coupling
- C09B35/02—Disazo dyes
- C09B35/039—Disazo dyes characterised by the tetrazo component
- C09B35/08—Disazo dyes characterised by the tetrazo component the tetrazo component being a derivative of biphenyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring (AREA)
Abstract
Preparation procedure of 5- (and 7-) benzoylindolin-2-ones effective to prevent the inflammatory response to pleural imitation, which have the formula: ** (See formula) ** wherein R is hydrogen or lower alcohol, and R1 is hydrogen, lower alcohol, halogen or trifluoromethyl, characterized by a) mixing and reacting an indolin-2-one of formula: ** (See formula) ** in which R is as defined above, with a benzoyl chloride of the formula: ** (See formula) ** wherein R1 is as defined above, or b) cyclizing a compound of the formula ** (See formula) ** wherein R1 is as defined above and R2 is H or C2H5. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25428472A | 1972-05-17 | 1972-05-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414802A1 true ES414802A1 (en) | 1976-02-01 |
Family
ID=22963675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414802A Expired ES414802A1 (en) | 1972-05-17 | 1973-05-16 | Substituted indolin-2-ones |
Country Status (17)
| Country | Link |
|---|---|
| JP (2) | JPS5139222B2 (en) |
| AT (1) | AT323731B (en) |
| BE (2) | BE799612A (en) |
| CA (1) | CA1000715A (en) |
| CH (1) | CH577469A5 (en) |
| DE (2) | DE943075C (en) |
| DK (1) | DK139677B (en) |
| ES (1) | ES414802A1 (en) |
| FI (1) | FI56377C (en) |
| FR (1) | FR2184933B1 (en) |
| GB (1) | GB1432577A (en) |
| IE (1) | IE37641B1 (en) |
| IL (1) | IL42216A (en) |
| NL (2) | NL183187C (en) |
| PH (1) | PH9815A (en) |
| SE (1) | SE393980B (en) |
| ZA (1) | ZA733151B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5371842U (en) * | 1976-11-17 | 1978-06-15 | ||
| US4221716A (en) * | 1979-02-16 | 1980-09-09 | A. H. Robins Company, Inc. | Intermediate and process for the preparation of 7-acylindolin-2-ones |
| DE3300522A1 (en) * | 1982-01-21 | 1983-07-28 | Sandoz-Patent-GmbH, 7850 Lörrach | 3,3-DIALKYL AND 3,3-ALKYLENE INDOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH232507A (en) * | 1941-02-18 | 1944-05-31 | Chem Ind Basel | Process for the preparation of a disazo dye. |
-
0
- NL NL90149D patent/NL90149C/xx active
- BE BE524637D patent/BE524637A/xx unknown
-
1953
- 1953-11-25 DE DEC8502A patent/DE943075C/en not_active Expired
-
1973
- 1973-05-07 FI FI1452/73A patent/FI56377C/en active
- 1973-05-08 IL IL42216A patent/IL42216A/en unknown
- 1973-05-09 ZA ZA733151A patent/ZA733151B/en unknown
- 1973-05-11 DK DK263073AA patent/DK139677B/en unknown
- 1973-05-11 PH PH14608A patent/PH9815A/en unknown
- 1973-05-15 CH CH689973A patent/CH577469A5/xx not_active IP Right Cessation
- 1973-05-15 SE SE7306853A patent/SE393980B/en unknown
- 1973-05-16 FR FR7317755A patent/FR2184933B1/fr not_active Expired
- 1973-05-16 DE DE2324767A patent/DE2324767C2/en not_active Expired
- 1973-05-16 AT AT429973A patent/AT323731B/en not_active IP Right Cessation
- 1973-05-16 CA CA171,512A patent/CA1000715A/en not_active Expired
- 1973-05-16 NL NLAANVRAGE7306832,A patent/NL183187C/en not_active IP Right Cessation
- 1973-05-16 GB GB2337473A patent/GB1432577A/en not_active Expired
- 1973-05-16 ES ES414802A patent/ES414802A1/en not_active Expired
- 1973-05-16 BE BE131181A patent/BE799612A/en not_active IP Right Cessation
- 1973-05-17 JP JP48054204A patent/JPS5139222B2/ja not_active Expired
- 1973-05-17 IE IE785/73A patent/IE37641B1/en unknown
-
1976
- 1976-05-13 JP JP51054786A patent/JPS5910660B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1000715A (en) | 1976-11-30 |
| FR2184933A1 (en) | 1973-12-28 |
| AT323731B (en) | 1975-07-25 |
| JPS5139222B2 (en) | 1976-10-26 |
| FI56377B (en) | 1979-09-28 |
| IE37641L (en) | 1973-11-17 |
| AU5584773A (en) | 1974-11-21 |
| NL7306832A (en) | 1973-11-20 |
| BE799612A (en) | 1973-09-17 |
| NL183187B (en) | 1988-03-16 |
| IL42216A (en) | 1976-08-31 |
| FR2184933B1 (en) | 1976-05-14 |
| CH577469A5 (en) | 1976-07-15 |
| IL42216A0 (en) | 1973-07-30 |
| NL90149C (en) | |
| DK139677B (en) | 1979-03-26 |
| PH9815A (en) | 1976-03-26 |
| JPS4941366A (en) | 1974-04-18 |
| DE943075C (en) | 1956-05-09 |
| ZA733151B (en) | 1974-04-24 |
| GB1432577A (en) | 1976-04-22 |
| JPS5217466A (en) | 1977-02-09 |
| IE37641B1 (en) | 1977-09-14 |
| SE393980B (en) | 1977-05-31 |
| DE2324767A1 (en) | 1973-11-29 |
| DE2324767C2 (en) | 1985-07-25 |
| BE524637A (en) | |
| NL183187C (en) | 1988-08-16 |
| JPS5910660B2 (en) | 1984-03-10 |
| FI56377C (en) | 1980-01-10 |
| DK139677C (en) | 1979-09-10 |
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