ES399367A1 - Procedure for the production of triazolbenzodiazepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the production of triazolbenzodiazepinas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES399367A1 ES399367A1 ES399367A ES399367A ES399367A1 ES 399367 A1 ES399367 A1 ES 399367A1 ES 399367 A ES399367 A ES 399367A ES 399367 A ES399367 A ES 399367A ES 399367 A1 ES399367 A1 ES 399367A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- alkyl
- translation
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- DEGSBVFPKYXUDB-UHFFFAOYSA-N (4-phenylquinolin-2-yl)hydrazine Chemical compound C=12C=CC=CC2=NC(NN)=CC=1C1=CC=CC=C1 DEGSBVFPKYXUDB-UHFFFAOYSA-N 0.000 abstract 1
- OBMBUODDCOAJQP-UHFFFAOYSA-N 2-chloro-4-phenylquinoline Chemical compound C=12C=CC=CC2=NC(Cl)=CC=1C1=CC=CC=C1 OBMBUODDCOAJQP-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Procedure for the production of triazobenzodiazepines, of formula I: **(See formula)** wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 3 carbon atoms inclusive; wherein R1 is hydrogen or alkyl defined as above; wherein R2, R3, R4 and R5 are selected from the group consisting of hydrogen, alkyl defined as above, fluorine, chlorine, bromine, nitro, cyano, trifluoromethyl, alkoxy of 1 to 3 carbon atoms inclusive, amino, alkanoylamino, in the which alkanoyl group has from 1 to 3 carbon atoms inclusive, alkylthio in which the alkyl group is defined as above, alkylsulfinyl in which the alkyl group is defined as above, and dialkylamino in which the chyl group is defined as above, characterized by comprising the following stages: 1. reflux a 2-chloro-4-phenylquinoline of formula II **(See formula)** wherein R2, R3, R4 and R5 are defined as above, with hydrazine hydrate to give the corresponding 2-hydrazino-4-phenylquinoline of formula (III): **(See formula)** where R2, R3, R4 and R5 are defined as above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11404971A | 1971-02-09 | 1971-02-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES399367A1 true ES399367A1 (en) | 1974-12-01 |
Family
ID=22353111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES399367A Expired ES399367A1 (en) | 1971-02-09 | 1972-02-01 | Procedure for the production of triazolbenzodiazepinas. (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4946639B1 (en) |
| ES (1) | ES399367A1 (en) |
| HU (1) | HU164348B (en) |
| IL (3) | IL41672A (en) |
| PH (3) | PH9300A (en) |
| SU (1) | SU444371A3 (en) |
-
1971
- 1971-05-11 JP JP46030888A patent/JPS4946639B1/ja active Pending
-
1972
- 1972-01-04 IL IL4167272A patent/IL41672A/en unknown
- 1972-01-04 IL IL4695372A patent/IL46953A/en unknown
- 1972-01-04 IL IL38505A patent/IL38505A/en unknown
- 1972-01-13 PH PH13193*UA patent/PH9300A/en unknown
- 1972-02-01 ES ES399367A patent/ES399367A1/en not_active Expired
- 1972-02-08 SU SU1745740A patent/SU444371A3/en active
- 1972-02-09 HU HUUO000074 patent/HU164348B/hu unknown
-
1974
- 1974-04-22 PH PH15766A patent/PH11466A/en unknown
-
1976
- 1976-09-01 PH PH18855A patent/PH13160A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL46953A (en) | 1977-07-31 |
| IL38505A (en) | 1977-07-31 |
| IL38505A0 (en) | 1972-03-28 |
| IL41672A (en) | 1977-07-31 |
| JPS4946639B1 (en) | 1974-12-11 |
| PH11466A (en) | 1978-02-01 |
| PH9300A (en) | 1975-08-15 |
| PH13160A (en) | 1980-01-08 |
| HU164348B (en) | 1974-01-28 |
| SU444371A3 (en) | 1974-09-25 |
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