ES416095A1 - A procedure for the preparation of 1,2,3,4-tetrahidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of 1,2,3,4-tetrahidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES416095A1
ES416095A1 ES416095A ES416095A ES416095A1 ES 416095 A1 ES416095 A1 ES 416095A1 ES 416095 A ES416095 A ES 416095A ES 416095 A ES416095 A ES 416095A ES 416095 A1 ES416095 A1 ES 416095A1
Authority
ES
Spain
Prior art keywords
amino
hydroxy
hydrogen
group
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES416095A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES416095A1 publication Critical patent/ES416095A1/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of 1,2,3,4-tetrahydroisoquinoline of general formula: **(See formula)** where R1 is hydrogen or a lower alkyl group, R'5 is hydroxy, amino, mono (lower) alkyl, dialkyl (lower) amino, lower alkoxy, aryl, nitro, halogen or haloalkyl lower, R'6 is hydrogen, hydroxy, amino, lower alkoxy or halogen R7 is hydrogen or a lower alkoxy group, and X is oxygen or sulfur, and their pharmaceutically acceptable acid salts, the process of which is to subject a 1-substituted derivative of 6,7-dihydroxy-1,2, 3,4-tetrahydroisoquinoline of the formula: **(See formula)** where R1, R7 and X are as defined above, R'and R''are hydrogen or a protecting group from the hydroxy group, R7 is a protecting group from the imino group, R5 is hydroxy, protected hydroxy, amino, protected amino, monoalkyl (lower) amino, dialkyl (lower) amino, lower alkoxy, aryl, nitro, halogen or lower haloalkyl and R6 is hydrogen, hydroxy, protected hydroxy, amino, protected amino, lower alkoxy or halogen to a reaction of separation of the protecting groups and If necessary, convert the resulting product to its acid salt by treating it with a pharmaceutically acceptable acid. (Machine-translation by Google Translate, not legally binding)
ES416095A 1972-06-20 1973-06-20 A procedure for the preparation of 1,2,3,4-tetrahidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding) Expired ES416095A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6196172A JPS55381B2 (en) 1972-06-20 1972-06-20

Publications (1)

Publication Number Publication Date
ES416095A1 true ES416095A1 (en) 1976-05-16

Family

ID=13186274

Family Applications (1)

Application Number Title Priority Date Filing Date
ES416095A Expired ES416095A1 (en) 1972-06-20 1973-06-20 A procedure for the preparation of 1,2,3,4-tetrahidroisoquinoleinas. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
JP (1) JPS55381B2 (en)
AR (1) AR205541A1 (en)
ES (1) ES416095A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58193042U (en) * 1982-06-18 1983-12-22 株式会社日立製作所 canister

Also Published As

Publication number Publication date
AR205541A1 (en) 1976-05-14
JPS55381B2 (en) 1980-01-08
JPS4920187A (en) 1974-02-22

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