ES421767A2 - A PROCEDURE FOR THE PREPARATION OF 5-SULFAMYL-BENZOIC ACIDS REPLACED IN POSITION 2. - Google Patents

A PROCEDURE FOR THE PREPARATION OF 5-SULFAMYL-BENZOIC ACIDS REPLACED IN POSITION 2.

Info

Publication number
ES421767A2
ES421767A2 ES421767A ES421767A ES421767A2 ES 421767 A2 ES421767 A2 ES 421767A2 ES 421767 A ES421767 A ES 421767A ES 421767 A ES421767 A ES 421767A ES 421767 A2 ES421767 A2 ES 421767A2
Authority
ES
Spain
Prior art keywords
formula
hydrogen
bromine
chlorine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421767A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00318213A external-priority patent/US3843662A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES421767A2 publication Critical patent/ES421767A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Improvements introduced in the object of the main patent No. 394,830 applied for on September 6, 1971 by: "A process for the preparation of 5-sulfamyl benzoic acids substituted in position 2" according to which when said acids are of the general formula: **(See formula)** and its amides, lower alkyl esters, and salts with pharmacologically acceptable bases; in the formula: Q is hydrogen, chlorine, fluorine, bromine, methoxy, methyl, dialkylamino lower, piperidino or hexamethyleneimino; T is chlorine, fluorine, bromine, methyl, methoxy, or trifluoromethyl; R16 is hydrogen or lower alkyl; R17 is lower alkyl or phenylalkylene of the formula: **(See formula)** in which: n has a value from 0 to 3 and each of the symbols R10 and R11 is hydrogen, methyl, chlorine, bromine or phenyl; and R16 and R17, when considered together with the nitrogen to which they are attached, form a heterocyclic ring selected from morpholino, piperidino, mono- and dimethylpiperidino or hexamethyleneimino; These improvements are characterized by: the reaction of an amine of the formula: **(See formula)** in which: R16 and R17 represent what is indicated above, with a compound of the formula: **(See formula)** in which: Hal is halogen and Q and T represent what is indicated above; and, if deemed convenient, then convert a compound of formula I, in which R16 is hydrogen, to N-alkyl by N-alkylization. (Machine-translation by Google Translate, not legally binding)
ES421767A 1972-12-26 1973-12-24 A PROCEDURE FOR THE PREPARATION OF 5-SULFAMYL-BENZOIC ACIDS REPLACED IN POSITION 2. Expired ES421767A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00318213A US3843662A (en) 1971-12-09 1972-12-26 2-halo-5-(substituted piperidino sulfonyl)benzoic acids

Publications (1)

Publication Number Publication Date
ES421767A2 true ES421767A2 (en) 1977-07-01

Family

ID=23237158

Family Applications (2)

Application Number Title Priority Date Filing Date
ES421767A Expired ES421767A2 (en) 1972-12-26 1973-12-24 A PROCEDURE FOR THE PREPARATION OF 5-SULFAMYL-BENZOIC ACIDS REPLACED IN POSITION 2.
ES74425208A Expired ES425208A1 (en) 1972-12-26 1974-04-10 PROCEDURE FOR THE PREPARATION OF 5-SULFAMILBENZOIC ACIDS SUBSTITUTED IN POSITION 2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES74425208A Expired ES425208A1 (en) 1972-12-26 1974-04-10 PROCEDURE FOR THE PREPARATION OF 5-SULFAMILBENZOIC ACIDS SUBSTITUTED IN POSITION 2.

Country Status (11)

Country Link
JP (2) JPS4986522A (en)
AR (1) AR214849A1 (en)
AU (1) AU6366973A (en)
BE (1) BE808939R (en)
CA (1) CA1012974A (en)
DE (1) DE2363786A1 (en)
ES (2) ES421767A2 (en)
FR (1) FR2211261B2 (en)
GB (1) GB1458029A (en)
NL (1) NL7317455A (en)
ZA (1) ZA739662B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983000013A1 (en) * 1980-11-10 1983-01-06 Mochida Pharm Co Ltd Medicinal composition having an antiviral effect
AU539797B2 (en) * 1981-06-22 1984-10-18 Hodogaya Chemical Co. Ltd. Aminosulfonyl benzoic acid derivatives
SE8203878L (en) * 1981-06-22 1982-12-23 Mochida Pharm Co Ltd VIRUS COMPOSITION
DE3732374A1 (en) * 1987-09-25 1989-04-06 Basf Lacke & Farben ZINC, LEAD AND / OR CALCIUM SALTS OF CARBONIC ACIDS AND THE USE THEREOF AS A CORROSION PROTECT
DE19941540C2 (en) * 1999-09-01 2002-08-29 Aventis Pharma Gmbh Sulfonylcarboxamides for the manufacture of medicaments for the prophylaxis or treatment of hyperlipidemia

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1122541B (en) * 1959-12-28 1962-01-25 Hoechst Ag Process for the production of sulfamyl-anthranilic acids
FR1472906A (en) * 1961-05-08 1967-03-17 Parke Davis & Co Esters of 4-halo-3-sulfamoylbenzoic acids and their production process
FR1450358A (en) * 1960-09-03 1966-06-24 Parke Davis & Co Production of new 4-halogeno-3-sulfamylbenzamides
FR1311859A (en) * 1961-09-18 1962-12-14 Soc Ind Fab Antibiotiques Sifa New sulfonamide derivatives, and method of preparation
US3565920A (en) * 1966-12-29 1971-02-23 Ciba Geigy Corp 5-sulfamyl-anthranilic acids
US3567746A (en) * 1968-07-10 1971-03-02 Pennwalt Corp N-aryl benzamides
US3700773A (en) * 1969-06-25 1972-10-24 Merck & Co Inc Substituted phenylsulfamyl salicyclic acids and derivatives thereof in the treatment of inflammation

Also Published As

Publication number Publication date
ZA739662B (en) 1975-01-29
FR2211261A2 (en) 1974-07-19
CA1012974A (en) 1977-06-28
AR214849A1 (en) 1979-08-15
GB1458029A (en) 1976-12-08
NL7317455A (en) 1974-06-28
FR2211261B2 (en) 1977-04-15
JPS5924975B2 (en) 1984-06-13
JPS58170756A (en) 1983-10-07
JPS4986522A (en) 1974-08-19
AU6366973A (en) 1975-06-19
DE2363786A1 (en) 1974-07-11
BE808939R (en) 1974-06-21
ES425208A1 (en) 1976-06-16

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