ES421969A1 - A procedure for the preparation of new heterociclic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of new heterocyclic compounds, of the general formula **(See formula)** in which (see formula) represents a cyclical system of the general formula **(See formula)** where R'represents hydrogen, halogen or lower alkyl, W represents a cycloalkyl radical containing from 5 to 7 cyclic carbon atoms or an aryl or heteroaryl radical other than an indolytic radical, and all these radicals can be substituted or unsubstituted, A represents a lower alkylene radical, a mono- or di-keto-lower alkylene radical, a hydroxy-lower alkyl radical or a bivalent radical of the formula (see formula) or -O- (lower alkylene) -, R represents a substituted or unsubstituted aryl radical (including heteroaryl radicals), aryl-lower alkyl, diaryl-lower alkyl, cycloalkyl with 5 to 7 cyclic carbon atoms or a lower alkyl radical, n is the integer 1, 2 or 3, X- is an anion, "acyl" is an acyl radical and the term "lower", as used herein, means the radical containing from 1 to 6 carbon atoms, and from the addition salts of acids and quaternary ammonium salts of the compounds in which (see formula) is a cyclic system II (c), except that (i) when W is unsubstituted phenyl, and A is methylene or ethylene, and R1 is hydrogen, and R is phenyl, which can be substituted or unsubstituted, phenyl-lower alkyl or lower alkyl, then the cyclic system, **(See formula)** it is a cyclic system of formula II (a); (ii) when W is a substituted or unsubstituted 5- or 6-membered heteroaryl radical, and A is a radical (see formula) and R1 is hydrogen or lower alkyl, then R is different from lower alkyl; (iii) when W is a 5- or 6-membered phenyl or heteroaryl radical, both of which can be substituted or unsubstituted, and A is a radical (see formula) and R1 is hydrogen, and the cyclic system (see formula) is a cyclic system of formula II (a), so R is other than lower alkyl; and (iv) when W is substituted or unsubstituted phenyl and A is a radical (see formula), and R1 is hydrogen or lower alkyl, then R is other than lower alkyl, characterized in that a compound of the general formula **(See formula)** where (see formula) represents a cyclical system of formula **(See formula)** and R1, [W] and A are as defined above, acylated with a reactive derivative of an acid of the general formula RCOOH, where R is as defined above. (Machine-translation by Google Translate, not legally binding)