ES423962A1 - Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y 7-sustituido-aminocefalosporanicos. - Google Patents

Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y 7-sustituido-aminocefalosporanicos.

Info

Publication number: ES423962A1
Authority: ES; Spain
Prior art keywords: group; substituted; choice; see formula; phenyl
Prior art date: 1972-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES423962A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gist Brocades NV

Original Assignee

Gist Brocades NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1972-12-22

Filing date

1974-03-06

Publication date

1976-07-01

1974-03-06 Application filed by Gist Brocades NV filed Critical Gist Brocades NV

1976-07-01 Publication of ES423962A1 publication Critical patent/ES423962A1/es

Status Expired legal-status Critical Current

Links

150000002391 heterocyclic compounds Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 11
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 9
125000000753 cycloalkyl group Chemical group 0.000 abstract 8
239000002253 acid Substances 0.000 abstract 7
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 7
-1 phenacyl group Chemical group 0.000 abstract 6
125000001424 substituent group Chemical group 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 4
125000000623 heterocyclic group Chemical group 0.000 abstract 4
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
150000007513 acids Chemical class 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
239000000460 chlorine Substances 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
125000001715 oxadiazolyl group Chemical group 0.000 abstract 2
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
HCXJFMDOHDNDCC-UHFFFAOYSA-N 5-$l^{1}-oxidanyl-3,4-dihydropyrrol-2-one Chemical group O=C1CCC(=O)[N]1 HCXJFMDOHDNDCC-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000002720 diazolyl group Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
125000001786 isothiazolyl group Chemical group 0.000 abstract 1
125000000842 isoxazolyl group Chemical group 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
150000002902 organometallic compounds Chemical class 0.000 abstract 1
125000002971 oxazolyl group Chemical group 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000003831 tetrazolyl group Chemical group 0.000 abstract 1
125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
230000009466 transformation Effects 0.000 abstract 1
125000001425 triazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ES423962A 1972-12-22 1974-03-06 Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y 7-sustituido-aminocefalosporanicos. Expired ES423962A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB5952472A GB1459392A (en)	1972-12-22	1972-12-22	Heterocyclic compounds

Publications (1)

Publication Number	Publication Date
ES423962A1 true ES423962A1 (es)	1976-07-01

Family

ID=10483917

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
ES421726A Expired ES421726A1 (es)	1972-12-22	1973-12-21	Procedimiento para preparar derivados de acidos 6-sustitui-do-amino-penicilanicos y 7-sustituido-aminocefalosporanicos.
ES423963A Expired ES423963A1 (es)	1972-12-22	1974-03-06	Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y cegalosporanicos.
ES423962A Expired ES423962A1 (es)	1972-12-22	1974-03-06	Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y 7-sustituido-aminocefalosporanicos.

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES421726A Expired ES421726A1 (es)	1972-12-22	1973-12-21	Procedimiento para preparar derivados de acidos 6-sustitui-do-amino-penicilanicos y 7-sustituido-aminocefalosporanicos.
ES423963A Expired ES423963A1 (es)	1972-12-22	1974-03-06	Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y cegalosporanicos.

Country Status (10)

Country	Link
JP (3)	JPS4994695A (es)
AT (1)	AT344318B (es)
BE (1)	BE809037A (es)
DE (2)	DE2365705A1 (es)
ES (3)	ES421726A1 (es)
FR (2)	FR2211232B1 (es)
GB (1)	GB1459392A (es)
HU (1)	HU167924B (es)
NL (2)	NL162654C (es)
SE (3)	SE7611135L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3905893A (en) *	1973-08-22	1975-09-16	Gulf Research Development Co	Plural stage residue hydrodesulfurization process

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1364453A (en) *	1970-11-06	1974-08-21	Gist Brocades Nv	Penicillanic and cepholosporanic acid derivatives

1972
- 1972-12-22 GB GB5952472A patent/GB1459392A/en not_active Expired
1973
- 1973-12-19 FR FR7345508A patent/FR2211232B1/fr not_active Expired
- 1973-12-20 NL NL7317432.A patent/NL162654C/xx active
- 1973-12-21 ES ES421726A patent/ES421726A1/es not_active Expired
- 1973-12-21 HU HUGI197A patent/HU167924B/hu unknown
- 1973-12-21 AT AT1072573A patent/AT344318B/de not_active IP Right Cessation
- 1973-12-21 DE DE2365705A patent/DE2365705A1/de active Pending
- 1973-12-21 BE BE139223A patent/BE809037A/xx unknown
- 1973-12-21 JP JP48143379A patent/JPS4994695A/ja active Pending
- 1973-12-21 DE DE2364129A patent/DE2364129A1/de not_active Withdrawn
1974
- 1974-03-06 ES ES423963A patent/ES423963A1/es not_active Expired
- 1974-03-06 ES ES423962A patent/ES423962A1/es not_active Expired
1976
- 1976-01-02 FR FR7600026A patent/FR2289171A1/fr not_active Withdrawn
- 1976-10-07 SE SE7611135A patent/SE7611135L/xx unknown
- 1976-10-07 SE SE7611134A patent/SE7611134L/xx unknown
1977
- 1977-11-30 JP JP14377377A patent/JPS5377088A/ja active Pending
- 1977-11-30 JP JP14377477A patent/JPS5373565A/ja active Pending
1978
- 1978-06-30 NL NL7807076A patent/NL7807076A/xx not_active Application Discontinuation
1979
- 1979-07-03 SE SE7905814A patent/SE7905814L/xx unknown

Also Published As

Publication number	Publication date
FR2289171A1 (fr)	1976-05-28
GB1459392A (en)	1976-12-22
NL7807076A (nl)	1978-10-31
SE7611135L (sv)	1976-10-07
DE2365705A1 (de)	1976-01-15
FR2211232B1 (es)	1978-01-13
SE7905814L (sv)	1979-07-03
ES421726A1 (es)	1976-04-16
JPS5373565A (en)	1978-06-30
NL162654C (nl)	1980-06-16
ES423963A1 (es)	1976-07-01
SE7611134L (sv)	1976-10-07
NL162654B (nl)	1980-01-15
DE2364129A1 (de)	1974-07-25
JPS5377088A (en)	1978-07-08
ATA1072573A (de)	1977-11-15
FR2211232A1 (es)	1974-07-19
NL7317432A (es)	1974-06-25
HU167924B (es)	1976-01-28
JPS4994695A (es)	1974-09-09
AT344318B (de)	1978-07-10
BE809037A (fr)	1974-06-21

Publication	Publication Date	Title
ES8607244A1 (es)	1986-06-01	Procedimiento para la preparacion de derivados de quinolina.
ES8704955A1 (es)	1987-04-16	Un proceso para la produccion de un compuesto de cefalospo- rina
ES438313A1 (es)	1977-05-16	Un procedimiento para la preparacion de 3-tiometilergolinas.
ES466539A1 (es)	1978-10-01	Procedimiento de preparacion de nuevos derivados del acido tiazolil-iminoacetico.
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GB1053085A (es)
GB1053825A (es)
GB1505885A (en)	1978-03-30	Substituted cephalosporins
ES423962A1 (es)	1976-07-01	Procedimiento para preparar derivados de acidos 6-sustitui-do-aminopenicilanicos y 7-sustituido-aminocefalosporanicos.
GB1382887A (en)	1975-02-05	Thiazole-5-carboxylic acid esters
JPS5562064A (en)	1980-05-10	Isatin derivative
ES438139A1 (es)	1977-05-01	Un procedimiento para preparar acidos tioxanton-2-carboxili-cos alquilsulfinil sustituidos.
ES479570A1 (es)	1979-12-01	Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina.
ES431673A1 (es)	1976-11-16	Un procedimiento para la preparacion de compuestos de 7- acilamido-7-metoxi-cefalosporina.
GB1055221A (en)	1967-01-18	Pyridobenzoxazepine derivatives
ES469182A1 (es)	1979-09-16	Un procedimiento para la preparacion de nuevos derivados de acido clavulanico
ES387561A1 (es)	1973-05-16	Procedimiento para la produccion de 2-acilamino - 1,3,4 - tiadiazol-(ti) onas-(2).
ES454266A1 (es)	1977-12-16	Un procedimiento para la produccion de un derivado reactivo en el grupo carboxilo de la 2,3-dioxipiperazina.
JPS5612395A (en)	1981-02-06	Oxazolinoazetidinone derivative
GB938815A (en)	1963-10-09	Iodine-containing benzoic acid derivatives
ES8200693A1 (es)	1981-11-01	Procedimiento para la preparacion de compuestos cefemicos
JPS54106495A (en)	1979-08-21	Cephem derivative
GB1528956A (en)	1978-10-18	Phenylalkanoic acid derivatives
ES430905A1 (es)	1976-10-16	Un procedimiento para la preparacion de derivados de cuma- rina.
ES426124A1 (es)	1976-11-01	Procedimiento de preparacion de nuevos derivados del acido cefalosporanico.