ES424204A1 - 1-oxadethiapenicillanic acid derivatives - Google Patents

1-oxadethiapenicillanic acid derivatives

Info

Publication number
ES424204A1
ES424204A1 ES424204A ES424204A ES424204A1 ES 424204 A1 ES424204 A1 ES 424204A1 ES 424204 A ES424204 A ES 424204A ES 424204 A ES424204 A ES 424204A ES 424204 A1 ES424204 A1 ES 424204A1
Authority
ES
Spain
Prior art keywords
beta
oxadethiapenicillanic
compounds
heterocyclic
radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424204A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES424204A1 publication Critical patent/ES424204A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

6 beta -Acylamino-1-oxadethiapenicillanic acids of the following formula < IMAGE > in which A denotes hydrogen or methoxy and R denotes an aliphatic, aromatic, heterocyclic, araliphatic or heterocyclic-aliphatic carboxylic acid radical or the 1-aminocyclohexylcarbonyl radical, are prepared. These compounds are obtained by introducing the carboxylic acid radical R into an appropriate 6 beta -amino compound or beta -benzamido compound. The acid group and/or the amino group in the starting compounds can be intermediately protected. The compounds obtained can also be converted into their salts, amide and ester derivatives. The penicillanic acids prepared can be used as antibiotics.
ES424204A 1973-03-13 1974-03-12 1-oxadethiapenicillanic acid derivatives Expired ES424204A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34080273A 1973-03-13 1973-03-13
US39751673A 1973-09-17 1973-09-17
US43274074A 1974-01-17 1974-01-17

Publications (1)

Publication Number Publication Date
ES424204A1 true ES424204A1 (en) 1976-10-16

Family

ID=27407422

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424204A Expired ES424204A1 (en) 1973-03-13 1974-03-12 1-oxadethiapenicillanic acid derivatives

Country Status (9)

Country Link
JP (1) JPS5029592A (en)
AR (1) AR214161A1 (en)
CH (1) CH616938A5 (en)
DE (1) DE2411856A1 (en)
ES (1) ES424204A1 (en)
FR (1) FR2221123B1 (en)
GB (1) GB1458410A (en)
NL (1) NL7402539A (en)
SE (1) SE417206B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361885A1 (en) * 1975-09-03 1978-03-17 Smithkline Corp ANALOGUES OF PENICILLIN, THEIR INTERMEDIARIES AND METHODS FOR OBTAINING THEM
GB1515241A (en) * 1976-01-27 1978-06-21 Beecham Group Ltd Beta-lactam antibiotics
FR2552764A1 (en) * 1983-05-17 1985-04-05 Chinoin Gyogyszer Es Vegyeszet SEMI-SYNTHETIC PHOSPHORUS-CONTAINING CEPHALOSPORANIC AND PENICILLANIC DERIVATIVES, PROCESS FOR PREPARING THESE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
JPH029786Y2 (en) * 1986-12-02 1990-03-12
JP5418814B2 (en) 2009-03-13 2014-02-19 山本光学株式会社 goggles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577408A (en) * 1968-10-15 1971-05-04 American Home Prod Tetrahydro-2-oxofuran penicillins
CA1024518A (en) * 1972-04-10 1978-01-17 Queen's University Azetidinones and their production and use

Also Published As

Publication number Publication date
DE2411856A1 (en) 1974-09-19
SE417206B (en) 1981-03-02
NL7402539A (en) 1974-09-17
CH616938A5 (en) 1980-04-30
GB1458410A (en) 1976-12-15
FR2221123A1 (en) 1974-10-11
FR2221123B1 (en) 1977-01-28
JPS5029592A (en) 1975-03-25
AR214161A1 (en) 1979-05-15
AU6629874A (en) 1975-09-11

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