IE44289L - (2-oxo-imidazolidin-1-yl-carbonyl (or thiocarbonyl)amino)-¹acetamido penicillins - Google Patents
(2-oxo-imidazolidin-1-yl-carbonyl (or thiocarbonyl)amino)-¹acetamido penicillinsInfo
- Publication number
- IE44289L IE44289L IE761360A IE136076A IE44289L IE 44289 L IE44289 L IE 44289L IE 761360 A IE761360 A IE 761360A IE 136076 A IE136076 A IE 136076A IE 44289 L IE44289 L IE 44289L
- Authority
- IE
- Ireland
- Prior art keywords
- compounds
- formula
- 1acetamido
- imidazolidin
- penicillins
- Prior art date
Links
- -1 2-oxo-imidazolidin-1-yl-carbonyl Chemical group 0.000 title abstract 2
- 229930182555 Penicillin Natural products 0.000 title abstract 2
- 150000002960 penicillins Chemical class 0.000 title 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 235000019730 animal feed additive Nutrition 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003566 thiocarboxylic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The title compounds correspond to the formula I; the symbols used are defined in Claim 1. The compounds are obtained by acylation of the optionally silylated amino group of the antibiotic derivatives of the formula II with a derivative of a carboxylic acid or thiocarboxylic acid of the formula III to form a -CE-NH linkage (E = oxygen or sulphur). Protective groups which are present are subsequently eliminated, and the beta -lactam compounds are finally obtained as free acids or as non-toxic salts. The compounds belong to the penicillin and cephalosporin series and can accordingly be used as antibiotics and as animal feed additives. They have a broad spectrum of action while being well tolerated. <IMAGE>
[GB1538284A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752528078 DE2528078A1 (en) | 1975-06-24 | 1975-06-24 | Alpha-(imidazolidinone carbonylamino) penicillins - and cephalosporins, antibacterials useful e.g. as feed additives |
| DE19752548663 DE2548663A1 (en) | 1975-10-30 | 1975-10-30 | Alpha-(imidazolidinone carbonylamino) penicillins - and cephalosporins, antibacterials useful e.g. as feed additives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE44289L true IE44289L (en) | 1976-12-24 |
| IE44289B1 IE44289B1 (en) | 1981-10-07 |
Family
ID=25769060
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE23/81A IE44290B1 (en) | 1975-06-24 | 1976-06-23 | 2-oxo-imidazolidine (-yl-carbonyl or thiocarbonyl-amino)-acetamido cephalosporins |
| IE1360/76A IE44289B1 (en) | 1975-06-24 | 1976-06-23 | 2-oxo-imidazolidine (-yl-carbonyl or thiocarbonyl-amino)-acetamido penicillins |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE23/81A IE44290B1 (en) | 1975-06-24 | 1976-06-23 | 2-oxo-imidazolidine (-yl-carbonyl or thiocarbonyl-amino)-acetamido cephalosporins |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS525789A (en) |
| AU (1) | AU498022B2 (en) |
| CH (1) | CH624958A5 (en) |
| DD (1) | DD126740A5 (en) |
| DK (1) | DK281276A (en) |
| ES (1) | ES449140A1 (en) |
| FI (1) | FI761807A7 (en) |
| FR (1) | FR2316940A1 (en) |
| GB (1) | GB1538284A (en) |
| GR (1) | GR60558B (en) |
| IE (2) | IE44290B1 (en) |
| IL (1) | IL49846A (en) |
| LU (1) | LU75217A1 (en) |
| NL (1) | NL7606789A (en) |
| SE (1) | SE7607218L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5985147U (en) * | 1982-11-30 | 1984-06-08 | ワイケイケイ株式会社 | blind cleaning equipment |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2407715C2 (en) * | 1974-02-18 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | Cephalosporins, processes for their production, as well as pharmaceuticals |
| IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
-
1976
- 1976-06-21 CH CH790676A patent/CH624958A5/en not_active IP Right Cessation
- 1976-06-21 IL IL49846A patent/IL49846A/en unknown
- 1976-06-22 LU LU75217A patent/LU75217A1/xx unknown
- 1976-06-22 JP JP51072860A patent/JPS525789A/en active Pending
- 1976-06-22 NL NL7606789A patent/NL7606789A/en not_active Application Discontinuation
- 1976-06-22 GR GR51062A patent/GR60558B/en unknown
- 1976-06-22 FI FI761807A patent/FI761807A7/fi not_active Application Discontinuation
- 1976-06-22 DD DD193508A patent/DD126740A5/xx unknown
- 1976-06-22 GB GB25844/76A patent/GB1538284A/en not_active Expired
- 1976-06-23 DK DK281276A patent/DK281276A/en unknown
- 1976-06-23 ES ES449140A patent/ES449140A1/en not_active Expired
- 1976-06-23 SE SE7607218A patent/SE7607218L/en unknown
- 1976-06-23 IE IE23/81A patent/IE44290B1/en unknown
- 1976-06-23 IE IE1360/76A patent/IE44289B1/en unknown
- 1976-06-24 AU AU15219/76A patent/AU498022B2/en not_active Expired
- 1976-06-24 FR FR7619246A patent/FR2316940A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2316940B1 (en) | 1978-12-15 |
| IL49846A (en) | 1979-07-25 |
| GR60558B (en) | 1978-06-22 |
| AU498022B2 (en) | 1979-02-01 |
| FI761807A7 (en) | 1976-12-25 |
| LU75217A1 (en) | 1977-03-15 |
| IE44290B1 (en) | 1981-10-07 |
| JPS525789A (en) | 1977-01-17 |
| CH624958A5 (en) | 1981-08-31 |
| DD126740A5 (en) | 1977-08-10 |
| SE7607218L (en) | 1976-12-25 |
| IL49846A0 (en) | 1976-08-31 |
| IE44289B1 (en) | 1981-10-07 |
| ES449140A1 (en) | 1977-07-16 |
| FR2316940A1 (en) | 1977-02-04 |
| GB1538284A (en) | 1979-01-17 |
| AU1521976A (en) | 1978-01-05 |
| NL7606789A (en) | 1976-12-28 |
| DK281276A (en) | 1976-12-25 |
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