ES430524A1 - Procedimiento para la obtencion de compuestos de rifamici- na-s sustituidos. - Google Patents

Procedimiento para la obtencion de compuestos de rifamici- na-s sustituidos.

Info

Publication number: ES430524A1
Authority: ES; Spain
Prior art keywords: group; substituted; lower alkyl; rifamycin; groups
Prior art date: 1973-09-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES430524A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Ciba Geigy AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-09-28

Filing date

1974-09-28

Publication date

1976-10-16

1973-09-28 Priority claimed from CH1396673A external-priority patent/CH594677A5/de

1973-09-28 Priority claimed from CH1396473A external-priority patent/CH594676A5/de

1974-07-26 Priority claimed from CH1031474A external-priority patent/CH622797A5/de

1974-09-28 Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG

1976-10-16 Publication of ES430524A1 publication Critical patent/ES430524A1/es

Status Expired legal-status Critical Current

Links

HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 title abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 6
125000002947 alkylene group Chemical group 0.000 abstract 5
AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 4
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000004450 alkenylene group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
BTVYFIMKUHNOBZ-ODRIEIDWSA-N Rifamycin S Chemical group O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-ODRIEIDWSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000001118 alkylidene group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
150000005208 1,4-dihydroxybenzenes Chemical class 0.000 abstract 1
-1 1-piperazinyl Chemical group 0.000 abstract 1
239000004215 Carbon black (E152) Substances 0.000 abstract 1
238000007126 N-alkylation reaction Methods 0.000 abstract 1
BTVYFIMKUHNOBZ-ZDHWWVNNSA-N Rifamycin S Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC(=O)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C BTVYFIMKUHNOBZ-ZDHWWVNNSA-N 0.000 abstract 1
HJYYPODYNSCCOU-ZDHWWVNNSA-N Rifamycin SV Natural products COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C)cc(O)c4c3C2=O HJYYPODYNSCCOU-ZDHWWVNNSA-N 0.000 abstract 1
125000002070 alkenylidene group Chemical group 0.000 abstract 1
229940100198 alkylating agent Drugs 0.000 abstract 1
239000002168 alkylating agent Substances 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229930195733 hydrocarbon Natural products 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000004885 piperazines Chemical class 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
229940109171 rifamycin sv Drugs 0.000 abstract 1
125000006413 ring segment Chemical group 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D269/00—Heterocyclic compounds containing rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms according to more than one of groups C07D261/00 - C07D267/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES430524A 1973-09-28 1974-09-28 Procedimiento para la obtencion de compuestos de rifamici- na-s sustituidos. Expired ES430524A1 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CH1396673A CH594677A5 (en)	1973-09-28	1973-09-28	3-(4-Substd.-1-piperazinyl) rifamycin S and SV derivs
CH1396473A CH594676A5 (en)	1973-09-28	1973-09-28	3-(4-Substd.-1-piperazinyl) rifamycin S and SV derivs
CH1031474A CH622797A5 (en)	1974-07-26	1974-07-26	Process for the preparation of antibiotically active rifamycin S and SV derivatives

Publications (1)

Publication Number	Publication Date
ES430524A1 true ES430524A1 (es)	1976-10-16

Family

ID=27176412

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES430524A Expired ES430524A1 (es)	1973-09-28	1974-09-28	Procedimiento para la obtencion de compuestos de rifamici- na-s sustituidos.

Country Status (24)

Country	Link
JP (1)	JPS6012358B2 (mo)
AR (2)	AR211845A1 (mo)
AT (1)	AT331406B (mo)
BG (2)	BG25378A3 (mo)
CA (1)	CA1055934A (mo)
CS (1)	CS199258B2 (mo)
DD (1)	DD114951A5 (mo)
DE (1)	DE2444728A1 (mo)
DK (1)	DK145949C (mo)
EG (1)	EG11775A (mo)
ES (1)	ES430524A1 (mo)
FI (1)	FI241674A7 (mo)
FR (1)	FR2245359B1 (mo)
GB (1)	GB1483621A (mo)
HU (1)	HU175580B (mo)
IE (1)	IE39919B1 (mo)
IL (1)	IL45735A (mo)
NL (1)	NL7412729A (mo)
NO (1)	NO743174L (mo)
OA (1)	OA04783A (mo)
RO (1)	RO71721A (mo)
SE (1)	SE420494B (mo)
SU (2)	SU644388A3 (mo)
YU (2)	YU39929B (mo)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1486118A (en) *	1975-03-05	1977-09-21	Lepetit Spa	Rifamycin derivatives
US7879834B2 (en)	2004-08-19	2011-02-01	Vertex Pharmaceuticals Incorporated	Spiroindoline modulators of muscarinic receptors
CA2634456A1 (en)	2005-12-22	2007-07-05	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors
US7858790B2 (en)	2006-06-29	2010-12-28	Vertex Pharmaceuticals Incorporated	Modulators of muscarinic receptors

1974
- 1974-08-08 DK DK422874A patent/DK145949C/da not_active IP Right Cessation
- 1974-08-15 FI FI2416/74A patent/FI241674A7/fi unknown
- 1974-08-16 SE SE7410465A patent/SE420494B/xx unknown
- 1974-09-04 NO NO743174A patent/NO743174L/no unknown
- 1974-09-13 GB GB40048/74A patent/GB1483621A/en not_active Expired
- 1974-09-18 FR FR7431472A patent/FR2245359B1/fr not_active Expired
- 1974-09-19 DE DE19742444728 patent/DE2444728A1/de not_active Withdrawn
- 1974-09-23 OA OA55303A patent/OA04783A/xx unknown
- 1974-09-25 YU YU2611/74A patent/YU39929B/xx unknown
- 1974-09-25 IL IL45735A patent/IL45735A/xx unknown
- 1974-09-26 NL NL7412729A patent/NL7412729A/xx not_active Application Discontinuation
- 1974-09-26 AR AR255770A patent/AR211845A1/es active
- 1974-09-26 CA CA210,125A patent/CA1055934A/en not_active Expired
- 1974-09-26 RO RO7491068A patent/RO71721A/ro unknown
- 1974-09-26 DD DD181346A patent/DD114951A5/xx unknown
- 1974-09-26 SU SU742062680A patent/SU644388A3/ru active
- 1974-09-27 IE IE2012/74A patent/IE39919B1/xx unknown
- 1974-09-27 BG BG027789A patent/BG25378A3/xx unknown
- 1974-09-27 AT AT778874A patent/AT331406B/de not_active IP Right Cessation
- 1974-09-27 CS CS746665A patent/CS199258B2/cs unknown
- 1974-09-27 HU HU74CI1512A patent/HU175580B/hu unknown
- 1974-09-27 BG BG030425A patent/BG25231A3/xx unknown
- 1974-09-28 JP JP49111016A patent/JPS6012358B2/ja not_active Expired
- 1974-09-28 EG EG433/74A patent/EG11775A/xx active
- 1974-09-28 ES ES430524A patent/ES430524A1/es not_active Expired
1975
- 1975-05-28 AR AR258992A patent/AR223798A1/es active
- 1975-07-31 SU SU752162195A patent/SU652895A3/ru active
1980
- 1980-12-10 YU YU3129/80A patent/YU40242B/xx unknown

Also Published As

Publication number	Publication date
YU312980A (en)	1982-10-31
SE420494B (sv)	1981-10-12
CS199258B2 (en)	1980-07-31
IE39919B1 (en)	1979-01-31
JPS5063000A (mo)	1975-05-29
DK145949C (da)	1983-09-26
BG25378A3 (bg)	1978-09-15
EG11775A (en)	1977-10-31
HU175580B (hu)	1980-09-28
FR2245359B1 (mo)	1978-07-21
AU7374774A (en)	1976-04-01
FR2245359A1 (mo)	1975-04-25
DK422874A (mo)	1975-05-20
RO71721A (ro)	1982-10-26
YU39929B (en)	1985-06-30
SE7410465L (mo)	1975-04-01
ATA778874A (de)	1975-11-15
CA1055934A (en)	1979-06-05
IL45735A (en)	1978-09-29
YU261174A (en)	1982-05-31
SU644388A3 (ru)	1979-01-25
FI241674A7 (mo)	1975-03-29
AR211845A1 (es)	1978-03-31
DK145949B (da)	1983-04-25
GB1483621A (en)	1977-08-24
SU652895A3 (ru)	1979-03-15
IL45735A0 (en)	1974-11-29
NO743174L (mo)	1975-04-28
AR223798A1 (es)	1981-09-30
DD114951A5 (mo)	1975-09-05
AT331406B (de)	1976-08-25
YU40242B (en)	1985-08-31
DE2444728A1 (de)	1975-04-10
OA04783A (fr)	1980-08-31
JPS6012358B2 (ja)	1985-04-01
NL7412729A (nl)	1975-04-02
BG25231A3 (bg)	1978-08-10
IE39919L (en)	1975-03-28

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