IE39919L - Rifamycins - Google Patents
RifamycinsInfo
- Publication number
- IE39919L IE39919L IE742012A IE201274A IE39919L IE 39919 L IE39919 L IE 39919L IE 742012 A IE742012 A IE 742012A IE 201274 A IE201274 A IE 201274A IE 39919 L IE39919 L IE 39919L
- Authority
- IE
- Ireland
- Prior art keywords
- groups
- manufacture
- lower alkyl
- alkyl groups
- radical
- Prior art date
Links
- 229930189077 Rifamycin Natural products 0.000 title 1
- BTVYFIMKUHNOBZ-QXMMDKDBSA-N rifamycin s Chemical class O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-QXMMDKDBSA-N 0.000 title 1
- 229940081192 rifamycins Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- SMPJCQGFZSDIHE-GVDHMVJUSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-amino-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl] acetate Chemical compound O=C1C(C(O)=C2C)=C3C(=O)C(N)=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O SMPJCQGFZSDIHE-GVDHMVJUSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000002365 anti-tubercular Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- HJYYPODYNSCCOU-ODRIEIDWSA-N rifamycin SV Chemical class OC1=C(C(O)=C2C)C3=C(O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O HJYYPODYNSCCOU-ODRIEIDWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D269/00—Heterocyclic compounds containing rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms according to more than one of groups C07D261/00 - C07D267/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCESS FOR THE MANUFACTURE OF NEW ANTIBIOTICALLY ACTIVE COMPOUNDS The invention refers to a process for the manufacture of selected 3-amino-rifamycin S and -SV derivatives, the amino group being of the aliphatic type, and more precisely being a 4R-1-piperazinyl- radical which is optionally substituted at the C-atoms by lower alkyl groups, and wherein R represents a hydrocarbon radical of the formula (III) , wherein Z1 - Z3 represent various hydrocarbon groups, including aromatic and cycloaliphatic groups, and Z' and Z" are optionally hydrogen or lower alkyl groups. These new compounds possess beyond a high general antibiotic action an especially high anti - tuberculosis effect, and are distinguished by a low toxicity.
[CA1055934A]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1396673A CH594677A5 (en) | 1973-09-28 | 1973-09-28 | 3-(4-Substd.-1-piperazinyl) rifamycin S and SV derivs |
| CH1396473A CH594676A5 (en) | 1973-09-28 | 1973-09-28 | 3-(4-Substd.-1-piperazinyl) rifamycin S and SV derivs |
| CH1031474A CH622797A5 (en) | 1974-07-26 | 1974-07-26 | Process for the preparation of antibiotically active rifamycin S and SV derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE39919L true IE39919L (en) | 1975-03-28 |
| IE39919B1 IE39919B1 (en) | 1979-01-31 |
Family
ID=27176412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2012/74A IE39919B1 (en) | 1973-09-28 | 1974-09-27 | Rifamycin derivatives |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS6012358B2 (en) |
| AR (2) | AR211845A1 (en) |
| AT (1) | AT331406B (en) |
| BG (2) | BG25378A3 (en) |
| CA (1) | CA1055934A (en) |
| CS (1) | CS199258B2 (en) |
| DD (1) | DD114951A5 (en) |
| DE (1) | DE2444728A1 (en) |
| DK (1) | DK145949C (en) |
| EG (1) | EG11775A (en) |
| ES (1) | ES430524A1 (en) |
| FI (1) | FI241674A7 (en) |
| FR (1) | FR2245359B1 (en) |
| GB (1) | GB1483621A (en) |
| HU (1) | HU175580B (en) |
| IE (1) | IE39919B1 (en) |
| IL (1) | IL45735A (en) |
| NL (1) | NL7412729A (en) |
| NO (1) | NO743174L (en) |
| OA (1) | OA04783A (en) |
| RO (1) | RO71721A (en) |
| SE (1) | SE420494B (en) |
| SU (2) | SU644388A3 (en) |
| YU (2) | YU39929B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1486118A (en) * | 1975-03-05 | 1977-09-21 | Lepetit Spa | Rifamycin derivatives |
| US7879834B2 (en) | 2004-08-19 | 2011-02-01 | Vertex Pharmaceuticals Incorporated | Spiroindoline modulators of muscarinic receptors |
| CA2634456A1 (en) | 2005-12-22 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
| US7858790B2 (en) | 2006-06-29 | 2010-12-28 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
-
1974
- 1974-08-08 DK DK422874A patent/DK145949C/en not_active IP Right Cessation
- 1974-08-15 FI FI2416/74A patent/FI241674A7/fi unknown
- 1974-08-16 SE SE7410465A patent/SE420494B/en unknown
- 1974-09-04 NO NO743174A patent/NO743174L/no unknown
- 1974-09-13 GB GB40048/74A patent/GB1483621A/en not_active Expired
- 1974-09-18 FR FR7431472A patent/FR2245359B1/fr not_active Expired
- 1974-09-19 DE DE19742444728 patent/DE2444728A1/en not_active Withdrawn
- 1974-09-23 OA OA55303A patent/OA04783A/en unknown
- 1974-09-25 YU YU2611/74A patent/YU39929B/en unknown
- 1974-09-25 IL IL45735A patent/IL45735A/en unknown
- 1974-09-26 NL NL7412729A patent/NL7412729A/en not_active Application Discontinuation
- 1974-09-26 AR AR255770A patent/AR211845A1/en active
- 1974-09-26 CA CA210,125A patent/CA1055934A/en not_active Expired
- 1974-09-26 RO RO7491068A patent/RO71721A/en unknown
- 1974-09-26 DD DD181346A patent/DD114951A5/xx unknown
- 1974-09-26 SU SU742062680A patent/SU644388A3/en active
- 1974-09-27 IE IE2012/74A patent/IE39919B1/en unknown
- 1974-09-27 BG BG027789A patent/BG25378A3/en unknown
- 1974-09-27 AT AT778874A patent/AT331406B/en not_active IP Right Cessation
- 1974-09-27 CS CS746665A patent/CS199258B2/en unknown
- 1974-09-27 HU HU74CI1512A patent/HU175580B/en unknown
- 1974-09-27 BG BG030425A patent/BG25231A3/en unknown
- 1974-09-28 JP JP49111016A patent/JPS6012358B2/en not_active Expired
- 1974-09-28 EG EG433/74A patent/EG11775A/en active
- 1974-09-28 ES ES430524A patent/ES430524A1/en not_active Expired
-
1975
- 1975-05-28 AR AR258992A patent/AR223798A1/en active
- 1975-07-31 SU SU752162195A patent/SU652895A3/en active
-
1980
- 1980-12-10 YU YU3129/80A patent/YU40242B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE37699B1 (en) | Novel pleuromutilins | |
| GB1526331A (en) | Phthalanes | |
| IE842930L (en) | Furopyridines | |
| AU574553B2 (en) | Difluorophenyl 1,3-thiazole derivatives | |
| GB1451999A (en) | Quinone derivatives | |
| ES445790A1 (en) | Piperazinylimino rifamycins | |
| GB1480772A (en) | Antibiotic derivatives | |
| GB1386992A (en) | Pesticidal compounds and compositions | |
| GB1427139A (en) | Penicillins | |
| GB1359415A (en) | Process for making aryloxy derivatives of aromatic diesters and dinitriles and products derived therefrom | |
| GB1355147A (en) | Oxoprostanoic acid derivatives | |
| IE39919B1 (en) | Rifamycin derivatives | |
| GB1511541A (en) | N-carbamoyloxyphenyl-carbamates their manufacture and their use as selective herbicides | |
| GB1440212A (en) | Derivatives of 2-phenoxyacetamido-5-nitrothiazoles | |
| GB1488430A (en) | Imino phthalides | |
| GB1431414A (en) | Prostanoic acid derivatives | |
| EP0180158B1 (en) | Thiadiazine compound, process for its preparation and pharmaceutical compositions containing it | |
| GR80832B (en) | Cyclic ethers | |
| AU563466B2 (en) | Antibiotic a 51568 factors a and b | |
| IE42941L (en) | Furo-furones | |
| GB1526038A (en) | 5-thiazole methane amine derivatives and salts thereof processes for preparing them and pharmaceutical compositions containing them | |
| NZ189091A (en) | Prostaglandin derivatives | |
| IE38611B1 (en) | Sydnone derivatives | |
| SE8302517L (en) | PROCEDURE FOR THE PREPARATION OF ANTIBIOTIC C-15003 P-0 (MAYTANSINOL) | |
| GB1504426A (en) | Clavulanic acid derivatives |