ES432500A1 - PROCEDURE FOR OBTAINING PLEUROMUTILINS. - Google Patents
PROCEDURE FOR OBTAINING PLEUROMUTILINS.Info
- Publication number
- ES432500A1 ES432500A1 ES432500A ES432500A ES432500A1 ES 432500 A1 ES432500 A1 ES 432500A1 ES 432500 A ES432500 A ES 432500A ES 432500 A ES432500 A ES 432500A ES 432500 A1 ES432500 A1 ES 432500A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- sulfur
- carbon atoms
- nitrogen atom
- pleuromutilins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 239000011593 sulfur Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Chemical group 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Procedure for obtaining substituted pleuromutilins of formula Ic, **(See formula)** where either R1 is ethyl or vinyl, n is an integer from 2 to 5, Y and Z are both sulfur, or one of Y and Z is oxygen and the other is sulfur, and each of RI2 and RI3 is alkyl of 1 to 10 carbon atoms, or RI2 and RI3 together with the nitrogen atom form a saturated 5- to 7-membered ring heterocycle containing one nitrogen atom or one nitrogen atom and an additional hetero member selected from sulfur, oxygen and a group = N-RI5, where RI5 is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms; characterized in that a compound of formula IIIa is reacted, **(See formula)** where R1, Y and Z have the meanings indicated above, with a compound of formula VI, **(See formula)** where n, RI2 and RI3 have the meanings indicated above, and A is the acidic radical of a reactive ester, conveniently in an inert solvent and at a temperature between room temperature and the boiling temperature of the mixture. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1445171A CH559719A5 (en) | 1971-10-05 | 1971-10-05 | Pleuromutilin derivs - with antibacterial activity |
| CH773972A CH568272A5 (en) | 1972-05-25 | 1972-05-25 | (Para-substd phenoxy- or phenylthio-acetoxy)-pleuromutilin deriv - prepd by reacting para-hydroxy or-mercapto cpds with e.g. aminoalkyl halides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES432500A1 true ES432500A1 (en) | 1977-03-01 |
Family
ID=25702062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES432500A Expired ES432500A1 (en) | 1971-10-05 | 1974-12-02 | PROCEDURE FOR OBTAINING PLEUROMUTILINS. |
Country Status (4)
| Country | Link |
|---|---|
| ES (1) | ES432500A1 (en) |
| PL (1) | PL92435B1 (en) |
| SU (1) | SU512706A3 (en) |
| YU (1) | YU37126B (en) |
-
1972
- 1972-10-03 PL PL17989272A patent/PL92435B1/pl unknown
-
1974
- 1974-01-25 SU SU1988833A patent/SU512706A3/en active
- 1974-12-02 ES ES432500A patent/ES432500A1/en not_active Expired
-
1979
- 1979-07-16 YU YU173779A patent/YU37126B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU37126B (en) | 1984-08-31 |
| SU512706A3 (en) | 1976-04-30 |
| YU173779A (en) | 1983-04-27 |
| PL92435B1 (en) | 1977-04-30 |
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