ES433573A1 - Procedure for preparing carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparing carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES433573A1 ES433573A1 ES433573A ES433573A ES433573A1 ES 433573 A1 ES433573 A1 ES 433573A1 ES 433573 A ES433573 A ES 433573A ES 433573 A ES433573 A ES 433573A ES 433573 A1 ES433573 A1 ES 433573A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- represented
- carbon atoms
- defined above
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000011968 lewis acid catalyst Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Procedure for preparing carbostyrilic derivatives, including 3,4-dihydrocarbostyrilics, laid down by formula (I) **(See formula)** in which R1, R4 and R5 each represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, at least R4 or R6 being a hydrogen atom, and R2 and R3, which may be the same or different, each representing a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group containing a straight or branched chain alkyl group having 1 to 4 carbon atoms in its alkyl moiety or a cycloalkyl group having 4 to 6 carbon atoms, or R2 and R3 can form, when taken together with the nitrogen atom to which they are attached, a substituted or unsubstituted 5- or 6-membered heterocyclic ring containing 1 or 2 nitrogen, oxygen or sulfur atoms as heteroatoms, characterized in that it comprises the steps of: (1) reacting a carbostyrilic or 3,4-dihydrocarbostyrilic compound of the formula (VI) **(See formula)** in which R4 and R5 are as defined above, with an alpha-alkanoic acid halide of the formula (see formula) in which X and X', which may be the same or different, each represent a halogen atom, in the presence or absence of a solvent and in the presence of a Lewis acid catalyst, to prepare a 5-haloalkalinocarbostyryl or 5-haloalkanoyl derivative -3,4-dihydrocarbostyryl represented by formula (IV) **(See formula)** in which R1, R4 and R5 are as defined above and X represents a halogen atom, (2) reacting the resulting 5-haloalkalinocarbostyryl or 5-haloalkanoyl-3,4-dihydrocarbostyryl derivative, represented by formula (IV), with an amine represented by formula (III) **(See formula)** wherein R2 and R3 are as defined above, in the presence or absence of a solvent, to prepare a 5-alkylominoalkanoylcarbostyryl or 5-alkylaminoalkanoyl-3, 4-dihydrocarbostyril derivative, represented by formula (II) **(See formula)** wherein R1, R2, R3, R4 and R5 are as defined above; and (3) reducing the resulting 5-alkylominoalkanoylcarbostryl derivative or 5-alkylaminoalkanoyl-3,4-dihydrocarbostyryl, represented by formula (II) in the presence of a catalyst or a reducing agent. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES433573A ES433573A1 (en) | 1973-12-26 | 1974-12-24 | Procedure for preparing carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP744192A JPS539227B2 (en) | 1973-12-26 | 1973-12-26 | |
| ES433573A ES433573A1 (en) | 1973-12-26 | 1974-12-24 | Procedure for preparing carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433573A1 true ES433573A1 (en) | 1977-03-01 |
Family
ID=26155891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433573A Expired ES433573A1 (en) | 1973-12-26 | 1974-12-24 | Procedure for preparing carbostirilic derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES433573A1 (en) |
-
1974
- 1974-12-24 ES ES433573A patent/ES433573A1/en not_active Expired
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