ES433890A1 - Procedimiento para la preparacion de nuevas bencilaminas. - Google Patents

Procedimiento para la preparacion de nuevas bencilaminas.

Info

Publication number: ES433890A1
Authority: ES; Spain
Prior art keywords: carbon atoms; cycloalkyl; alkyl; hydroxy; hydrogen
Prior art date: 1973-04-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES433890A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-13

Filing date

1975-01-17

Publication date

1976-12-01

1973-04-13 Priority claimed from DE19732318636 external-priority patent/DE2318636B2/de

1974-01-23 Priority claimed from DE19742402989 external-priority patent/DE2402989C3/de

1975-01-17 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1976-12-01 Publication of ES433890A1 publication Critical patent/ES433890A1/es

Status Expired legal-status Critical Current

Links

150000003939 benzylamines Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 6
-1 cyano, carbamoyl Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000005350 hydroxycycloalkyl group Chemical group 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/24—Camphidines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ES433890A 1973-04-13 1975-01-17 Procedimiento para la preparacion de nuevas bencilaminas. Expired ES433890A1 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19732318636 DE2318636B2 (de)	1973-04-13	1973-04-13	Neue benzylamine, sie enthaltende arzneimittel und verfahren zu ihrer herstellung
DE19742402989 DE2402989C3 (de)	1974-01-23	1974-01-23	Neue Benzylamine, sie enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ES433890A1 true ES433890A1 (es)	1976-12-01

Family

ID=25764968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES433890A Expired ES433890A1 (es)	1973-04-13	1975-01-17	Procedimiento para la preparacion de nuevas bencilaminas.

Country Status (6)

Country	Link
US (1)	US3950393A (es)
CH (3)	CH609034A5 (es)
ES (1)	ES433890A1 (es)
PH (1)	PH12617A (es)
PL (2)	PL96888B1 (es)
SU (3)	SU645553A3 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4203901A (en) *	1978-08-21	1980-05-20	Gaf Corporation	Process for making N-(N'-methylenepyrrolidonyl)-2-substituted anilines
US4404222A (en) *	1980-08-25	1983-09-13	American Cyanamid Company	Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby
IT1126509B (it) *	1979-12-07	1986-05-21	Medea Res Srl	Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono
US4407819A (en) *	1980-08-25	1983-10-04	American Cyanamid Company	Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals
US4432995A (en) *	1980-12-22	1984-02-21	American Cyanamid Company	5-[2-(Ethylamino)-1-hydroxylethyl] anthranilonitrile and the use thereof in meat producing animals
US4562201A (en) *	1982-07-26	1985-12-31	American Hospital Supply Corporation	Aminomethyl benzanilides
US5530029A (en) *	1987-09-15	1996-06-25	The Rowett Research Institute	Therapeutic applications of clenbuterol
US5541188A (en) *	1987-09-15	1996-07-30	The Rowett Research Institute	Therapeutic applications of beta-adrenergic agonists
FR2653123B1 (fr) *	1989-10-17	1992-01-17	Roussel Uclaf	Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5242942A (en) *	1992-04-28	1993-09-07	Mcneilab, Inc.	Anticonvulsant fructopyranose cyclic sulfites and sulfates
US5332743A (en) *	1992-06-12	1994-07-26	Mcneilab, Inc.	Benzyl and benzhydryl alcohols
US5432284A (en) *	1993-09-08	1995-07-11	G. D. Searle & Co.	Process for the preparation of heterocyclic alkylamide derivatives
MXPA04001253A (es) *	2001-08-09	2004-06-03	Ono Pharmaceutical Co	Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.
PL378119A1 (pl) *	2003-02-07	2006-03-06	Ono Pharmaceutical Co., Ltd.	Kwasy karboksylowe
US20080274150A1 (en) *	2005-11-16	2008-11-06	Mark Dierker	Process For Removing Odors From Hydrocarbons
US8022217B2 (en) *	2006-07-31	2011-09-20	Cadila Healthcare Limited	Compounds suitable as modulators of HDL
CN104211604B (zh) *	2014-08-18	2016-05-11	江苏正大清江制药有限公司	一种氨溴索与对羟基苯甲酸的共晶及其制备方法
CN104211605B (zh) *	2014-08-18	2016-04-27	江苏正大清江制药有限公司	一种氨溴索与间羟基苯甲酸共晶及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3793292A (en) *	1971-04-12	1974-02-19	Daiichi Seiyaku Co	Esters of 4-aminomethyl benzoic acid

1974
- 1974-04-05 US US05/458,099 patent/US3950393A/en not_active Expired - Lifetime
- 1974-04-05 PH PH15708A patent/PH12617A/en unknown
- 1974-04-09 CH CH528777A patent/CH609034A5/xx not_active IP Right Cessation
- 1974-04-09 CH CH528477A patent/CH609033A5/xx not_active IP Right Cessation
- 1974-04-09 CH CH528377A patent/CH609328A5/xx not_active IP Right Cessation
- 1974-04-12 PL PL1974181439A patent/PL96888B1/pl unknown
- 1974-04-12 PL PL1974181430A patent/PL96218B1/pl unknown
1975
- 1975-01-17 ES ES433890A patent/ES433890A1/es not_active Expired
- 1975-01-30 SU SU752101050A patent/SU645553A3/ru active
- 1975-01-30 SU SU2101061A patent/SU543341A3/ru active
- 1975-01-30 SU SU2101059A patent/SU521837A3/ru active

Also Published As

Publication number	Publication date
SU521837A3 (ru)	1976-07-15
CH609328A5 (es)	1979-02-28
US3950393A (en)	1976-04-13
PH12617A (en)	1979-07-05
PL96888B1 (pl)	1978-01-31
PL96218B1 (pl)	1977-12-31
CH609034A5 (es)	1979-02-15
SU543341A3 (ru)	1977-01-15
SU645553A3 (ru)	1979-01-30
CH609033A5 (es)	1979-02-15

Publication	Publication Date	Title
ES433890A1 (es)	1976-12-01	Procedimiento para la preparacion de nuevas bencilaminas.
ES452921A1 (es)	1977-11-01	Procedimiento para la preparacion de nuevas amidas de acidosamino-benzoicos.
IE46158L (en)	1978-04-05	Propanolamine derivatives
ES467565A1 (es)	1978-10-16	Procedimiento para la preparacion de nuevas 4-acilamino-fe- nil-etanol-aminas.
ES416037A1 (es)	1976-02-16	Procedimiento para la preparacion de 2-(heteroaril-metil)- 5,9b-dialcohil-6,7-benzomorfanos.
ES431059A1 (es)	1976-10-16	Procedimiento para la preparacion de nuevos n-(metoximetil - furilmetil)-6, 7-benzomorfanos y -morfinanos.
SE7709865L (sv)	1978-03-04	Nya fenyletylaminer och forfarande for framstellning derav
ES430119A1 (es)	1976-10-16	Procedimiento para la preparacion de nuevos derivados de 2-fenilamino-imidazolina-(2).
GB1086192A (en)	1967-10-04	Phenylcyclopropane derivatives
ES433148A1 (es)	1977-02-16	Procedimiento para preparar derivados de pirazol.
SE7605361L (sv)	1976-11-17	Sett att framstella nya n-substituerade fenylpiperazinderivat
FI812321L (fi)	1982-01-25	Nya i 5-position substituerade 5,10-dihydro-iih-dibanzo/b e//1,4/diazepin-ii-oner foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel
ES359454A1 (es)	1970-06-01	Procedimiento de preparacion de nuevos esteres aminoalcohi-lados de acidos anilino-2 nicotinico.
ES411341A1 (es)	1976-03-16	Procedimiento para la preparacion de compuestos heteroci- clicos sustituidos por un radical guanidinilideno.
ES465225A1 (es)	1978-09-16	Procedimiento para la preparacion de n-cicloalcohilmetil-2- fenilamino-imidazolinas-(2).
ES417006A1 (es)	1976-03-01	Procedimiento para la preparacion de 4-fenil-imidazolinas.
ES454668A1 (es)	1977-12-01	Procedimiento para la preparacion de nuevas homoftalimidas.
ES425216A1 (es)	1976-05-16	Procedimiento para la preparacion de nuevas triazolo - 1,5 - benzodiazepinas sustituidas.
SE7606497L (sv)	1976-12-11	Substituerade 4-fenylimidazoliner, deras syraadditinossalter och forfarande for framstellning derav
ES468586A1 (es)	1978-11-16	Procedimiento para la preparacion de nuevas piridobenzodia- zepinonas.
ES465561A1 (es)	1978-09-16	Procedimiento para la preparacion de nuevas aril-alcohilami-nas.
ES417269A1 (es)	1976-03-16	Procedimiento para preparar derivados de imidazolidinona.
ES424801A1 (es)	1976-06-16	Procedimiento para la preparacion de nuevas 3,6-bis-(ami- noacilamino)-acridinas.
ES414805A1 (es)	1976-03-16	Un procedimiento para preparar monoesteres de alfa-carboxi-bencilpenicilina.
GB1377306A (en)	1974-12-11	Esters of 2-quinoxalinecarboxylic acid di n-oxide