ES433893A1 - PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES.Info
- Publication number
- ES433893A1 ES433893A1 ES433893A ES433893A ES433893A1 ES 433893 A1 ES433893 A1 ES 433893A1 ES 433893 A ES433893 A ES 433893A ES 433893 A ES433893 A ES 433893A ES 433893 A1 ES433893 A1 ES 433893A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- hydrogen atom
- radicals
- compound
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003939 benzylamines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- -1 aromatic acyl radical Chemical class 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000001723 carbon free-radicals Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical group C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 stands for a hydrogen atom, chlorine or bromine, R4 and R5, which may be the same or different, represent hydrogen atoms, straight or branched chain 1 to 5 carbon radicals, which may be substituted by one or two hydroxy groups, alkenyl radicals with 2 to 4 carbon atoms, cycloalkyl radicals with 5 to 7 carbon atoms, optionally substituted with one or two hydroxy groups, benzyl, morpholinocarbonylmethyl or together with the nitrogen atom signify a pyrrolidine, piperidine, hexamethylenamine ring, morpholine, N-methyl-piperazine or camfidine, as well as their acid addition salts physiologically compatible with organic or inorganic acids, characterized in that a compound of the general formula II is hydrolyzed **(See formula)** wherein R1, R2, R4 and R5 are as initially defined and A represents a functional derivative of the carboxyl group; and, if desired, a compound of the general formula I obtained, in which R1 represents a hydrogen atom and R2, R4 and R5, with the exception of radicals containing a hydrogen atom capable of reacting, are as defined initially, it is acylated if desired subsequently, and/or a compound obtained of the general formula I is transformed if desired into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES433893A ES433893A1 (en) | 1973-04-13 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19732318636 DE2318636B2 (en) | 1973-04-13 | 1973-04-13 | NEW BENZYLAMINES, MEDICINAL PRODUCTS AND THE METHOD OF MANUFACTURING THEM |
| DE19742402989 DE2402989C3 (en) | 1974-01-23 | 1974-01-23 | New benzylamines, pharmaceuticals containing them and processes for their manufacture |
| DE19742405322 DE2405322A1 (en) | 1974-02-05 | 1974-02-05 | NEW METHODS FOR MANUFACTURING BENZYLAMINES |
| ES424432A ES424432A1 (en) | 1973-04-13 | 1974-03-20 | Substituted aminobenzylamines |
| ES433893A ES433893A1 (en) | 1973-04-13 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433893A1 true ES433893A1 (en) | 1976-11-16 |
Family
ID=27510306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433893A Expired ES433893A1 (en) | 1973-04-13 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES433893A1 (en) |
-
1975
- 1975-01-17 ES ES433893A patent/ES433893A1/en not_active Expired
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