ES433896A1 - PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. - Google Patents
PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES.Info
- Publication number
- ES433896A1 ES433896A1 ES433896A ES433896A ES433896A1 ES 433896 A1 ES433896 A1 ES 433896A1 ES 433896 A ES433896 A ES 433896A ES 433896 A ES433896 A ES 433896A ES 433896 A1 ES433896 A1 ES 433896A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- radical
- compound
- carbon atoms
- signifies
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003939 benzylamines Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- -1 cyano, carbamoyl Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of new benzylamines of the general formula I **(See formula)** wherein R1 signifies a hydrogen atom or an optionally substituted aliphatic or aromatic acyl radical; R2 signifies a hydrogen, chlorine or bromine atom, R3 signifies a fluorine atom, a branched-chain or branched-chain 1 to 4-carbon alcohol radical, a trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl group, 1-hydroxyethyl as well as the aminomethyl group of the formula **(See formula)** wherein R6 and R7, which may be the same or different, represent alcohol, cycloalcohyl or hydroxycycloalcohyl groups or together with the nitrogen atom a pyrrolidine, piperidine or morpholine ring; R4 represents a hydrogen atom, an alcohol radical with 1 to 5 straight or branched chain carbon atoms, which may be substituted with one or two hydroxy groups, an alkenyl radical with 2 to 4 carbon atoms, a cycloalkoxy radical with 5 to 7 carbon atoms optionally substituted with one or two hydroxy groups, a benzyl or morpholinocarbonylmethyl group; and R5 signifies a straight or branched chain alcohol radical with 1 to 5 carbon atoms, a cycloalcohyl radical with 5 to 7 carbon atoms, a benzyl or morpholinocarbonylmethyl group, as well as its acid addition salts physiologically compatible with organic acids or inorganic, characterized in that it undergoes alcoholization of a compound of the general formula **(See formula)** wherein R1, R2, R3 and R4 are as initially defined, with a compound of the general formula III R5 - W (III) where R5 has the initially mentioned meanings, and W represents a halogen atom or a sulfonic acid radical; and, if desired, a compound of the general formula I obtained in which R3 represents a cyano group, is transformed by partial hydrolysis into the corresponding carbamoyl compound of the general formula I, and/or a compound obtained of the general formula I, in which R1 represents a hydrogen atom and R2, R3, R4 and R5, with the exception of the radicals containing a hydrogen atom capable of reacting, are as initially defined, is acylated if desired later, and/or a compound obtained from the general formula I is transformed, if desired, into its physiologically compatible salts with organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES433896A ES433896A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742405322 DE2405322A1 (en) | 1974-02-05 | 1974-02-05 | NEW METHODS FOR MANUFACTURING BENZYLAMINES |
| ES424432A ES424432A1 (en) | 1973-04-13 | 1974-03-20 | Substituted aminobenzylamines |
| ES433896A ES433896A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES433896A1 true ES433896A1 (en) | 1976-11-16 |
Family
ID=27185762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES433896A Expired ES433896A1 (en) | 1974-02-05 | 1975-01-17 | PROCEDURE FOR THE PREPARATION OF NEW BENZYLAMINES. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES433896A1 (en) |
-
1975
- 1975-01-17 ES ES433896A patent/ES433896A1/en not_active Expired
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