ES437080A1 - Piperidine derivatives - Google Patents
Piperidine derivativesInfo
- Publication number
- ES437080A1 ES437080A1 ES437080A ES437080A ES437080A1 ES 437080 A1 ES437080 A1 ES 437080A1 ES 437080 A ES437080 A ES 437080A ES 437080 A ES437080 A ES 437080A ES 437080 A1 ES437080 A1 ES 437080A1
- Authority
- ES
- Spain
- Prior art keywords
- novel
- piperidine derivatives
- radical
- piperidylamides
- amidopiperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003053 piperidines Chemical class 0.000 title 1
- DODZXZATBLWUGA-UHFFFAOYSA-N 1-(4-fluorophenyl)-4-(piperidin-4-ylamino)butan-1-one Chemical class C1=CC(F)=CC=C1C(=O)CCCNC1CCNCC1 DODZXZATBLWUGA-UHFFFAOYSA-N 0.000 abstract 1
- QHDXPJMOWRLLRV-UHFFFAOYSA-N 1-(4-fluorophenyl)butan-1-one Chemical compound CCCC(=O)C1=CC=C(F)C=C1 QHDXPJMOWRLLRV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel N-(p-fluorobenzoylpropyl)-4-piperidylamides of the formula I below, in which R is a hydrogen atom, a straight-chain or branched alkyl radical with 1 to 15 carbon atoms, the tetrahydrofuryl, furyl, thienyl, phenyl or adamantyl radical, are prepared by reacting a correspondingly substituted amidopiperidine with a p-fluorobutyrophenone which has in the omega position a group which can be eliminated under the reaction conditions. The products of the process can be converted into their physiologically acceptable acid addition salts. The novel compounds show the typical range of effects of neuroleptics and can therefore be employed as CNS-depressant agents, sedatives and tranquillisers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2423897A DE2423897C3 (en) | 1974-05-16 | 1974-05-16 | N- (p-FluorobenzoyIpropyl) -4piperidylamides, process for their preparation and pharmaceutical preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES437080A1 true ES437080A1 (en) | 1977-02-01 |
Family
ID=5915760
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES437080A Expired ES437080A1 (en) | 1974-05-16 | 1975-04-28 | Piperidine derivatives |
| ES441383A Expired ES441383A1 (en) | 1974-05-16 | 1975-10-30 | Piperidine derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441383A Expired ES441383A1 (en) | 1974-05-16 | 1975-10-30 | Piperidine derivatives |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS50160281A (en) |
| AT (2) | AT342591B (en) |
| BE (1) | BE829140A (en) |
| CH (2) | CH613445A5 (en) |
| DE (1) | DE2423897C3 (en) |
| DK (1) | DK213675A (en) |
| ES (2) | ES437080A1 (en) |
| FI (1) | FI59400C (en) |
| FR (1) | FR2270877B1 (en) |
| GB (1) | GB1500973A (en) |
| NL (1) | NL7505710A (en) |
| NO (1) | NO144671C (en) |
| SE (1) | SE416129B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| DE19952146A1 (en) | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkanes, arylalkenes and aryl-azaalkanes, medicaments containing these compounds and process for their preparation |
-
1974
- 1974-05-16 DE DE2423897A patent/DE2423897C3/en not_active Expired
-
1975
- 1975-04-23 AT AT310275A patent/AT342591B/en not_active IP Right Cessation
- 1975-04-28 ES ES437080A patent/ES437080A1/en not_active Expired
- 1975-05-05 FI FI751317A patent/FI59400C/en not_active IP Right Cessation
- 1975-05-13 CH CH612075A patent/CH613445A5/en not_active IP Right Cessation
- 1975-05-15 NL NL7505710A patent/NL7505710A/en not_active Application Discontinuation
- 1975-05-15 BE BE156408A patent/BE829140A/en not_active IP Right Cessation
- 1975-05-15 DK DK213675A patent/DK213675A/en unknown
- 1975-05-15 JP JP50057905A patent/JPS50160281A/ja active Pending
- 1975-05-15 SE SE7505587A patent/SE416129B/en unknown
- 1975-05-15 NO NO751724A patent/NO144671C/en unknown
- 1975-05-15 GB GB20708/75A patent/GB1500973A/en not_active Expired
- 1975-05-16 FR FR7515385A patent/FR2270877B1/fr not_active Expired
- 1975-10-30 ES ES441383A patent/ES441383A1/en not_active Expired
-
1977
- 1977-01-07 AT AT4077A patent/AT342594B/en not_active IP Right Cessation
-
1979
- 1979-04-19 CH CH369979A patent/CH614704A5/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2423897B2 (en) | 1978-12-21 |
| ATA310275A (en) | 1977-08-15 |
| NL7505710A (en) | 1975-11-18 |
| FI59400C (en) | 1981-08-10 |
| NO144671C (en) | 1981-10-14 |
| NO144671B (en) | 1981-07-06 |
| AT342591B (en) | 1978-04-10 |
| FR2270877A1 (en) | 1975-12-12 |
| JPS50160281A (en) | 1975-12-25 |
| FI59400B (en) | 1981-04-30 |
| AT342594B (en) | 1978-04-10 |
| SE7505587L (en) | 1975-11-17 |
| FI751317A7 (en) | 1975-11-17 |
| DE2423897C3 (en) | 1979-09-06 |
| ES441383A1 (en) | 1977-04-01 |
| SE416129B (en) | 1980-12-01 |
| FR2270877B1 (en) | 1978-10-06 |
| DK213675A (en) | 1975-11-17 |
| CH613445A5 (en) | 1979-09-28 |
| NO751724L (en) | 1975-11-18 |
| CH614704A5 (en) | 1979-12-14 |
| AU8119575A (en) | 1976-11-18 |
| BE829140A (en) | 1975-11-17 |
| DE2423897A1 (en) | 1975-11-27 |
| ATA4077A (en) | 1977-08-15 |
| GB1500973A (en) | 1978-02-15 |
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