ES438364A1 - Gentamicin derivatives - Google Patents
Gentamicin derivativesInfo
- Publication number
- ES438364A1 ES438364A1 ES438364A ES438364A ES438364A1 ES 438364 A1 ES438364 A1 ES 438364A1 ES 438364 A ES438364 A ES 438364A ES 438364 A ES438364 A ES 438364A ES 438364 A1 ES438364 A1 ES 438364A1
- Authority
- ES
- Spain
- Prior art keywords
- gentamicin
- vary
- free
- derivatives
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical class O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 title abstract 4
- 229930182566 Gentamicin Natural products 0.000 abstract 2
- 229960002518 gentamicin Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Procedure for obtaining new gentamicin derivatives, of general formula: ** (See formula) ** in which G represents the rest of a gentamicin molecule, n can vary from 1 to 5, m can vary from 0 to 4, with the sum of n and m always equal to 5, and R can be hydrogen or a methyl group, characterized by reacting the gentamicin free or in the form of an addition salt with an acid, with the free n-dodecyl-sulfuric acid or in the form of a metal salt or ammonium substituted or not. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7418556A FR2272680B1 (en) | 1974-05-29 | 1974-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES438364A1 true ES438364A1 (en) | 1977-01-16 |
Family
ID=9139390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES438364A Expired ES438364A1 (en) | 1974-05-29 | 1975-05-28 | Gentamicin derivatives |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE821600A (en) |
| DE (2) | DE2446640A1 (en) |
| ES (1) | ES438364A1 (en) |
| FR (1) | FR2272680B1 (en) |
| GB (1) | GB1478240A (en) |
| LU (1) | LU72590A1 (en) |
| NL (1) | NL7506362A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10114245A1 (en) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Production and use of an antibiotic / antibiotic preparation |
| DE10114364A1 (en) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Process for the production of antibiotic composites |
| DE10114244A1 (en) * | 2001-03-22 | 2002-10-02 | Heraeus Kulzer Gmbh & Co Kg | Antibiotic / antibiotic preparation with active ingredient release |
| IS6389A (en) | 2001-08-31 | 2003-03-03 | Heraeus Kulzer Gmbh & Co. Kg | Experiences of antibiotic coating of carcasses containing microspheres, and also of such coated carcasses and their use |
| IS6390A (en) | 2001-08-31 | 2003-03-03 | Heraeus Kulzer Gmbh & Co. Kg | Experiences of antibiotic coating of carcasses containing microspheres, thus coated carcasses and also of their use |
| DE10262176B4 (en) | 2002-06-21 | 2007-10-04 | Heraeus Kulzer Gmbh | Process for the preparation of antibiotically coated porous bodies and use |
| DE10227938B4 (en) | 2002-06-21 | 2006-07-20 | Heraeus Kulzer Gmbh | Pharmaceutical preparation, process for its preparation and its use |
-
1974
- 1974-05-29 FR FR7418556A patent/FR2272680B1/fr not_active Expired
- 1974-09-30 DE DE19742446640 patent/DE2446640A1/en not_active Withdrawn
- 1974-10-29 BE BE149981A patent/BE821600A/en unknown
-
1975
- 1975-04-21 DE DE19752517600 patent/DE2517600A1/en not_active Withdrawn
- 1975-05-23 GB GB2294675A patent/GB1478240A/en not_active Expired
- 1975-05-28 ES ES438364A patent/ES438364A1/en not_active Expired
- 1975-05-28 LU LU72590A patent/LU72590A1/xx unknown
- 1975-05-29 NL NL7506362A patent/NL7506362A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2446640A1 (en) | 1975-12-11 |
| FR2272680B1 (en) | 1978-07-21 |
| BE821600A (en) | 1975-02-17 |
| FR2272680A1 (en) | 1975-12-26 |
| DE2517600A1 (en) | 1975-12-18 |
| LU72590A1 (en) | 1975-10-08 |
| GB1478240A (en) | 1977-06-29 |
| NL7506362A (en) | 1975-12-02 |
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