ES440153A2 - Piperazinopyrimidines process for their preparation and use - Google Patents

Piperazinopyrimidines process for their preparation and use

Info

Publication number
ES440153A2
ES440153A2 ES440153A ES440153A ES440153A2 ES 440153 A2 ES440153 A2 ES 440153A2 ES 440153 A ES440153 A ES 440153A ES 440153 A ES440153 A ES 440153A ES 440153 A2 ES440153 A2 ES 440153A2
Authority
ES
Spain
Prior art keywords
formula
preparation
see formula
alkyl group
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES440153A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Produits Chimiques Ugine Kuhlmann
Pechiney SA
Original Assignee
Produits Chimiques Ugine Kuhlmann
Ugine Kuhlmann SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Produits Chimiques Ugine Kuhlmann, Ugine Kuhlmann SA filed Critical Produits Chimiques Ugine Kuhlmann
Publication of ES440153A2 publication Critical patent/ES440153A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Improvements introduced in the object of the main Patent nº 418115 by: "A PROCEDURE FOR THE PREPARATION OF NEW PIPERAZINO-PIRIMIDINES", consisting in that the obtained compounds respond to the general formula: **(See formula)** where Z represents an alkyl group of 1 to 4 carbon atoms, R1 represents a hydrogen atom or a methyl or ethyl group and R2 represents a linear alkyl group of 5 to 6 carbon atoms, allyl, hydroxyethyl, cycloalkyl of 3 to 8 carbon, benzyl or p-methoxyphenyl atoms, the rest -NR1R1 being able to represent a mofolino group, by reaction of a dichloro 4,6 methylthio-5 pyrimidine of general formula **(See formula)** with a piperazine of formula (see formula), in anhydrous medium, in the presence of an acid accepting agent and at a temperature between 40ºC and 120ºC. (Machine-translation by Google Translate, not legally binding)
ES440153A 1974-08-09 1975-08-08 Piperazinopyrimidines process for their preparation and use Expired ES440153A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7427671A FR2281117A2 (en) 1974-08-09 1974-08-09 NEW PIPERAZINO-PYRIMIDINES FOR USE AS MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
ES440153A2 true ES440153A2 (en) 1977-07-01

Family

ID=9142279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES440153A Expired ES440153A2 (en) 1974-08-09 1975-08-08 Piperazinopyrimidines process for their preparation and use

Country Status (13)

Country Link
JP (2) JPS51125089A (en)
AR (1) AR205579A1 (en)
BE (1) BE832277R (en)
CA (1) CA1036598A (en)
CH (1) CH609692A5 (en)
DE (1) DE2534963A1 (en)
ES (1) ES440153A2 (en)
FR (1) FR2281117A2 (en)
GB (1) GB1512101A (en)
LU (1) LU73175A1 (en)
NL (1) NL7509184A (en)
NO (1) NO752586L (en)
ZA (1) ZA755118B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2417507A2 (en) * 1977-07-28 1979-09-14 Ugine Kuhlmann DIAMINO-2,4 (OR -4,6) METHYLTHIO-5 PYRIMIDINES HERBICIDES
FR2503162A1 (en) * 1981-04-07 1982-10-08 Pharmindustrie NOVEL PIPERAZINO-2 PYRIMIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS OR AS INTERMEDIATES FOR THE PRODUCTION OF MEDICAMENTS
JPS5973573A (en) * 1982-09-09 1984-04-25 ワ−ナ−−ランバ−ト・コンパニ− Diaminopyrimidine compound
US6825198B2 (en) 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
KR20060032190A (en) * 2003-07-02 2006-04-14 버텍스 파마슈티칼스 인코포레이티드 Pyrimidines useful as regulators of voltage-gated ion channels
WO2006130493A2 (en) 2005-05-31 2006-12-07 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2119234A5 (en) * 1970-12-24 1972-08-04 Ugine Kuhlmann 5-alkylthio amino halopyrimidines - fungicides herbicides insecticides and bactericides
FR2173746B1 (en) * 1972-03-01 1975-04-25 Ugine Kuhlmann

Also Published As

Publication number Publication date
NO752586L (en) 1976-02-10
ZA755118B (en) 1976-07-28
JPS51125089A (en) 1976-11-01
FR2281117B2 (en) 1978-07-28
CA1036598A (en) 1978-08-15
AR205579A1 (en) 1976-05-14
NL7509184A (en) 1976-02-11
CH609692A5 (en) 1979-03-15
BE832277R (en) 1976-02-09
LU73175A1 (en) 1976-03-02
FR2281117A2 (en) 1976-03-05
JPS5946943B2 (en) 1984-11-15
DE2534963A1 (en) 1976-02-19
JPS58150571A (en) 1983-09-07
GB1512101A (en) 1978-05-24

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